基因页：ESR1
概括?
| 基因 | 2099 |
| 象征 | ESR1 |
| Synonyms | ER|ESR|ESRA|ESTRR|Era|NR3A1 |
| Description | estrogen receptor 1 |
| Reference | MIM：133430|HGNC:HGNC:3467|Ensembl:ENSG00000091831|HPRD：00589|Vega:OTTHUMG00000016103 |
| 基因类型 | protein-coding |
| 地图位置 | 6Q25.1 |
| Pascal p-value | 0.85 |
| Fetal beta | -0.912 |
| DMG | 1（＃研究） |
| eGene | 迈尔斯的顺式和跨性别 元 |
数据源中的基因
| 基因集名称 | Method of gene set | Description | Info |
|---|---|---|---|
| CV：GWASDB | 全基因组关联研究 | 精神分裂症的GWASDB记录 | |
| CV:PGCnp | 全基因组协会研究 | GWAS | |
| DMG：Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| PMID:cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| 表达 | 基因表达的荟萃分析 | Pvalue: 2.351 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias | 点击to show details |
| 网络 | 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 | PPI网络中最短路径的贡献：0.4727 |
第一节遗传学和表观遗传学注释
差异甲基化基因
差异甲基化基因| 探测 | 染色体 | 位置 | 最近的基因 | P (dis) | beta（dis） | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg18007957 | 6 | 152011666 | ESR1 | 5.682E-4 | 0.422 | 0.049 | DMG：Wockner_2014 |
EQTL注释
| SNP ID | 染色体 | 位置 | eGene | Gene Entrez ID | PVALUE | qvalue | TSS distance | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| rs443832 | CHR16 | 83779643 | ESR1 | 2099 | 0.16 | 反式 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| 前10个积极共表达的基因 | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CAMKK1 | 0.93 | 0.78 |
| SYT12 | 0.93 | 0.86 |
| EHD3 | 0.92 | 0.91 |
| mast3 | 0.92 | 0.87 |
| SLC12A5 | 0.92 | 0.86 |
| CNTNAP1 | 0.91 | 0.87 |
| SIRPA | 0.91 | 0.90 |
| iqsec1 | 0.91 | 0.85 |
| PHF15 | 0.91 | 0.82 |
| MAP1A | 0.90 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| Bcl7c | -0.54 | -0.65 |
| C9orf46 | -0.53 | -0.63 |
| GTF3C6 | -0.52 | -0.57 |
| exosc8 | -0.51 | -0.59 |
| FAM36A | -0.50 | -0.50 |
| Dynlt1 | -0.49 | -0.67 |
| AC006276.2 | -0.49 | -0.50 |
| RBMX2 | -0.48 | -0.62 |
| RPS8 | -0.48 | -0.65 |
| RPL36 | -0.48 | -0.64 |
Section III. Gene Ontology annotation
| 分子功能 | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| 去：0004872 | receptor activity | IEA | - | |
| 去：0003677 | DNA结合 | IEA | - | |
| 去：0003700 | 转录factor activity | IEA | - | |
| 去：0003707 | steroid hormone receptor activity | IEA | - | |
| 去：0003707 | steroid hormone receptor activity | nas | 11004670 | |
| GO：0030235 | 一氧化物合酶调节剂活性 | nas | 12389206 | |
| 去:0005496 | 类固醇结合 | IEA | - | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO：0030284 | estrogen receptor activity | nas | 3753802 | |
| GO：0046872 | metal ion binding | IEA | - | |
| GO：0047485 | protein N-terminus binding | IPI | 12917342 | |
| GO：0043565 | sequence-specific DNA binding | IEA | - | |
| 生物过程 | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0006355 | regulation of transcription, DNA-dependent | nas | 3753802 | |
| GO:0030520 | estrogen receptor signaling pathway | nas | 3753802 | |
| GO:0006350 | 转录 | IEA | - | |
| GO:0007165 | 信号转导 | 塔斯 | 10749889|10970861 | |
| GO：0048386 | 视黄酸受体信号通路的正调控 | 艾达 | 15831516 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0005634 | nucleus | IEA | - | |
| 去：0005634 | nucleus | nas | - | |
| GO:0005730 | 核仁 | 艾达 | 18029348 | |
| GO:0005737 | cytoplasm | 艾达 | 18029348 | |
| 去：0005886 | 质膜 | 艾达 | 18029348 | |
| GO：0016585 | chromatin remodeling complex | nas | 12351687 |
第四节。蛋白质蛋白相互作用注释
| 互动者 | 别名b | 官方全名b | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ER与LOC441967相互作用。 | 绑定 | 16009131 | |||
| 啊 | - | 芳基烃受体 | - | HPRD，Biogrid | 10620335|12612060 |
| AKAP13 | AKAP-LBC |brx |FLJ11952 |FLJ43341 |ha-3 |HT31 |LBC |原始-LB |原始-LBC |C-LBC | 激酶（PRKA）锚蛋白13 | - | HPRD，Biogrid | 9627117 |
| ANP32A | C15orf1 |i1pp2a |lanp |mapm |MGC119787 |MGC150373 |phap1 |phapi |pp32 | 酸性（富含亮氨酸）核磷蛋白32家族，成员A | ER-alpha interacts with pp32. | 绑定 | 15308690 |
| AP1B1 | ADTB1 |AP105A |BAM22 |clapb2 | adaptor-related protein complex 1, beta 1 subunit | ER与AP1B1相互作用。 | 绑定 | 16009131 |
| AR | AIS |DHTR |Humara |KD |NR3C4 |SBMA |smax1 |TFM | 雄激素受体 | - | HPRD，Biogrid | 12389206 |
| ASCC2 | ASC1p100 | activating signal cointegrator 1 complex subunit 2 | ER与ASC1P100相互作用。 | 绑定 | 16009131 |
| AXIN2 | 轴|DKFZP781B0869 |MGC10366 |MGC126582 | axin 2 | ER-alpha interacts with the Axin2 promoter. | 绑定 | 15304487 |
| Bag1 | Rap46 | BCl2相关的雅典纪 | - | HPRD，Biogrid | 8524784 |
| Bage3 | - | B melanoma antigen family, member 3 | ER interacts with BAGE3. | 绑定 | 16009131 |
| BAZ1B | WBSCR10 |WBSCR9 |WSTF | 与锌指域相邻的溴结构域，1B | Affinity Capture-Western | BioGRID | 12837248 |
| BCAS2 | DAM1 | breast carcinoma amplified sequence 2 | BCAS2与ER-Alpha相互作用。这种相互作用是基于未指定物种的人类BCAS2和ER-α之间的相互作用进行建模的。 | 绑定 | 15694360 |
| BDNF | MGC34632 | 脑衍生的神经营养因子 | - | HPRD | 11923430 |
| bloc1s1 | BLOS1 | FLJ39337 | FLJ97089 | GCN5L1 | MGC87455 | MICoA | RT14 | 溶酶体细胞器复合物1，亚基1的生物发生1 | ER与MICOA相互作用 | 绑定 | 12639951 |
| BRCA1 | Brcai |BRCC1 |虹膜|PSCP |RNF53 | 乳腺癌1，早发 | - | HPRD | 10334989 |
| BRCA1 | Brcai |BRCC1 |虹膜|PSCP |RNF53 | 乳腺癌1，早发 | Affinity Capture-Western Co-localization Reconstituted Complex |
BioGRID | 11244506|11493692 |11782371|12400015 |
| C21orf129 | FLJ32835 | PRED76 | 染色体21开放阅读框129 | ER interacts with C21orf129. | 绑定 | 16009131 |
| 平静1 | Calml2 |CAMI |DD132 |PHKD | 钙调蛋白1（磷酸化酶激酶，三角洲） | - | HPRD | 11981030 |
| CALM2 | CAMII | PHKD | PHKD2 | calmodulin 2 (phosphorylase kinase, delta) | - | HPRD | 11981030 |
| CALM3 | PHKD| PHKD3 | 钙调蛋白3（磷酸化酶激酶，三角洲） | - | HPRD | 11981030 |
| CAV1 | CAV | MSTP085 | VIP21 | caveolin 1, caveolae protein, 22kDa | - | HPRD，Biogrid | 11563984 |
| CCND1 | bcl1 |D11S287E |prad1 |U21B31 | cyclin D1 | - | HPRD，Biogrid | 9039267 |
| CCND1 | bcl1 |D11S287E |prad1 |U21B31 | cyclin D1 | ER-Alpha与细胞周期蛋白D1启动子相互作用。 | 绑定 | 15808510 |
| CCNH | cak |p34 |p37 | 细胞周期蛋白h | Affinity Capture-Western | BioGRID | 12527756 |
| CDC25B | - | 细胞分裂周期25同源物B（S. pombe） | - | HPRD，Biogrid | 11689696 |
| CDK7 | CAK1 | CDKN7 | MO15 | STK1 | p39MO15 | 细胞周期蛋白依赖性激酶7 | Biochemical Activity | BioGRID | 10949034 |
| 宿雾 | C/EBP-alpha | CEBP | CCAAT/增强子结合蛋白（C/EBP），α | Reconstituted Complex | BioGRID | 9817600 |
| CEBPB | C/EBP-beta |CRP2 |IL6DBP |圈|MGC32080 |nf-il6 |TCF5 | CCAAT/增强子结合蛋白（C/EBP），β | - | HPRD，Biogrid | 7651415 |
| CELSR1 | CDHF9 | DKFZp434P0729 | FMI2 | HFMI2 | ME2 | 钙粘蛋白，EGF滞后七通G型受体1（Flamingo同源物，果蝇） | ER与CELSR1相互作用。 | 绑定 | 16009131 |
| 楚克 | ikbka |ikk-alpha |ikk1 |ikka |nfkbika |TCF16 | 保守的螺旋环螺旋无处不在激酶 | IKK-Alpha与ER-Alpha相互作用。 | 绑定 | 15808510 |
| COBRA1 | DKFZP586B0519 |KIAA1182 |nelf-b |Nelfb | cofactor of BRCA1 | - | HPRD，Biogrid | 15342491 |
| CREBBP | CBP | KAT3A | RSTS | CREB结合蛋白 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 11113179|11782371 |
| CSNK1E | HCKIE | MGC10398 | casein kinase 1, epsilon | ER interacts with CSNK1E. | 绑定 | 16009131 |
| CTNNB1 | ctnnb |DKFZP686D02253 |FLJ25606 |FLJ37923 | Catenin（cadherin相关蛋白），β1，88KDA | Affinity Capture-Western | BioGRID | 15304487 |
| CTNNB1 | ctnnb |DKFZP686D02253 |FLJ25606 |FLJ37923 | Catenin（cadherin相关蛋白），β1，88KDA | β-catenin与ER-Alpha相互作用。 | 绑定 | 15304487 |
| CYB5R3 | B5R | DIA1 | cytochrome b5 reductase 3 | ER与CYB5R3相互作用。 | 绑定 | 16009131 |
| DAP3 | DAP-3 | DKFZp686G12159 | MGC126058 | MGC126059 | MRP-S29 | MRPS29 | bMRP-10 | death associated protein 3 | Reconstituted Complex | BioGRID | 10903152 |
| DDX17 | DKFZP761H2016 |P72 |RH70 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | ESR1 (ER-alpha) interacts with an unspecified isoform of DDX17 (p72). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and DDX17 from an unspecified species. | 绑定 | 12738788 |
| DDX5 | DKFZP686J01190 |G17P1 |HLR1 |hump68 |P68 | 死亡（ASP-GLU-ALA-ASP）盒多肽5 | Affinity Capture-Western 两个杂交 |
BioGRID | 10409727 |
| DDX5 | DKFZP686J01190 |G17P1 |HLR1 |hump68 |P68 | 死亡（ASP-GLU-ALA-ASP）盒多肽5 | ESR1（ER-Alpha）与DDX5（p68）相互作用。这种相互作用是根据未指定物种的ESR1与来自未指定物种的DDX5之间的相互作用进行建模的。 | 绑定 | 12738788 |
| DDX54 | DP97 |MGC2835 | 死亡（ASP-GLU-ALA-ASP）盒多肽54 | - | HPRD，Biogrid | 12466272 |
| DNTTIP2 | ERBP | FCF2 | HSU15552 | LPTS-RP2 | MGC163494 | RP4-561L24.1 | TdIF2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | - | HPRD，Biogrid | 15047147 |
| DSCAM | CHD2-42 |CHD2-52 | Down syndrome cell adhesion molecule | ER interacts with DSCAM-1 enhancer. | 绑定 | 16009131 |
| EBAG9 | EB9 | PDAF | RCAS1 | estrogen receptor binding site associated, antigen, 9 | ER-Alpha与EBAG9启动子相互作用。 | 绑定 | 15808510 |
| EGFR | ERBB |ERBB1 |her1 |PIG61 |梅纳 | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | - | HPRD，Biogrid | 11887937 |
| EIF3I | EIF3S2 |Pro2242 |Trip-1 |Trip1 |eif3-beta |EIF3-P36 | 真核翻译引发因子3，亚基I | ER alpha interacts with TRIP1. This interaction was modeled on a demonstrated interaction between TRIP1 from an unspecified source and human ER alpha. | 绑定 | 10706629 |
| EP300 | kat3b |P300 | E1a结合蛋白p300 | - | HPRD，Biogrid | 11782371 |
| EP300 | kat3b |P300 | E1a结合蛋白p300 | EP300（P300）乙酰酸ESR1（ER-Alpha）。这种相互作用是根据未指定物种的EP300与来自未指定物种的ESR1之间的相互作用进行建模的。 | 绑定 | 14761960 |
| ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | estrogen receptor 1 | 两个杂交 | BioGRID | 12198596 |
| ESR2 | ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2 | 雌激素受体2（ERβ） | ER Alpha与ER Beta相互作用以形成异二聚体。这种相互作用是建立在人类ERα和小鼠ERβ之间的相互作用上的模型。 | 绑定 | 10706629 |
| ESR2 | ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2 | 雌激素受体2（ERβ） | - | HPRD，Biogrid | 9473491 |
| FHL2 | AAG11 | DRAL | SLIM3 | four and a half LIM domains 2 | ER-alpha interacts with FHL2. | 绑定 | 15666801 |
| FKBP4 | FKBP52 | FKBP59 | HBI | Hsp56 | PPIase | p52 | FK506结合蛋白4，59KDA | Reconstituted Complex | BioGRID | 9222609 |
| FKBP5 | FKBP51 |FKBP54 |MGC111006 |p54 |PPIASE |PTG-10 | FK506 binding protein 5 | Reconstituted Complex | BioGRID | 9222609 |
| FOXO1 | FKH1 |fkhr |foxo1a | 叉子盒O1 | - | HPRD，Biogrid | 11435445 |
| FOXO4 | AFX |afx1 |MGC120490 |mllt7 | 叉子盒O4 | - | HPRD，Biogrid | 11435445 |
| GADD45A | DDIT1 | GADD45 | 增长逮捕和DNA-damage-inducible, alpha | Affinity Capture-Western | BioGRID | 10872826 |
| GADD45B | DKFZP566B133 |gadd45beta |myd118 | 增长逮捕和DNA-damage-inducible, beta | - | HPRD | 10872826 |
| GADD45G | CR6 | DDIT2 | GADD45gamma | GRP17 | 增长逮捕和DNA-damage-inducible, gamma | - | HPRD，Biogrid | 10872826 |
| GTF2H1 | BTF2 | TFB1 | TFIIH | general transcription factor IIH, polypeptide 1, 62kDa | - | HPRD，Biogrid | 10949034 |
| HDAC1 | DKFZP686H12203 |gon-10 |HD1 |RPD3 |RPD3L1 | histone deacetylase 1 | 和HDAC1 ER-alpha交互。 | 绑定 | 14506733 |
| HSP90AA1 | FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | - | HPRD，Biogrid | 11911945 |
| HSPA4 | APG-2 |HS24/p52 |MGC131852 |Ry |HSP70 |HSP70RY | heat shock 70kDa protein 4 | Reconstituted Complex | BioGRID | 9222609 |
| IGF1R | CD221 |igfir |JTK13 |MGC142170 |MGC142172 |MGC18216 | 胰岛素样生长因子1受体 | Affinity Capture-Western | BioGRID | 16113100 |
| ISL1 | ISL-1 | ISL LIM homeobox 1 | - | HPRD，Biogrid | 11043578 |
| jarid1a | KDM5A | RBBP2 | RBP2 | jumonji, AT rich interactive domain 1A | Affinity Capture-Western Reconstituted Complex |
BioGRID | 11358960 |
| jarid1a | KDM5A | RBBP2 | RBP2 | jumonji, AT rich interactive domain 1A | Rbp2 interacts with ER. | 绑定 | 11358960 |
| JUN | AP-1 | AP1 | c-Jun | Jun Oncogene | ER-Alpha与C-Jun相互作用。这种相互作用是在人类ER-Alpha和小鼠C-Jun之间证明的相互作用上建模的。 | 绑定 | 11477071 |
| JUN | AP-1 | AP1 | c-Jun | Jun Oncogene | - | HPRD，Biogrid | 11477071 |
| Junb | AP-1 | Jun B原型癌基因 | ER-Alpha与Junb相互作用。这种相互作用是建立在人类ER-α和小鼠JUNB之间的相互作用上的模型。 | 绑定 | 11477071 |
| loh3cr2a | ERR-10 | ERR10 | NAG-7 | NAG7 | 杂合性丧失，3，染色体区域2，基因A | - | HPRD | 15474036 |
| MAPK1 | ERK |ERK2 |ERT1 |MAPK2 |p42mapk |prkm1 |prkm2 |p38 |P40 |P41 | p41mapk | mitogen-activated protein kinase 1 | - | HPRD，Biogrid | 12093745 |
| MDM2 | HDMX |MGC71221 |HDM2 | MDM2 p53结合蛋白同源物（小鼠） | Reconstituted Complex | BioGRID | 10766163 |
| Med1 | CRSP1 |CRSP200 |滴水205 |滴水230 |MGC71488 |PBP |PPARBP |PPARGBP |RB18A |TRAP220 | TRIP2 | 介体复合体亚基1 | ESR1 (ER-alpha) interacts with PPARBP (TRAP220). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and PPARBP from an unspecified species. | 绑定 | 12738788 |
| Med1 | CRSP1 |CRSP200 |滴水205 |滴水230 |MGC71488 |PBP |PPARBP |PPARGBP |RB18A |TRAP220 | TRIP2 | 介体复合体亚基1 | Affinity Capture-Western | BioGRID | 12837248 |
| Med1 | CRSP1 |CRSP200 |滴水205 |滴水230 |MGC71488 |PBP |PPARBP |PPARGBP |RB18A |TRAP220 | TRIP2 | 介体复合体亚基1 | - | HPRD | 9653119 |
| MED24 | ARC100 |CRSP100 |CRSP4 |滴100 |KIAA0130 |MGC8748 |thrap4 |陷阱100 | mediator complex subunit 24 | - | HPRD | 9653119 |
| MED24 | ARC100 |CRSP100 |CRSP4 |滴100 |KIAA0130 |MGC8748 |thrap4 |陷阱100 | mediator complex subunit 24 | 亲和力捕获ms | BioGRID | 12837248 |
| Mgmt | - | O-6-甲基鸟嘌呤-DNA甲基转移酶 | Affinity Capture-Western Reconstituted Complex 两个杂交 |
BioGRID | 11564893 |
| MKNK2 | GPRK7 | MNK2 | MAP激酶相互作用丝氨酸/苏氨酸激酶2 | - | HPRD，Biogrid | 11013076 |
| MMS19 | FLJ34167 | FLJ95146 | MET18 | MGC99604 | MMS19L | hMMS19 | MMS19nucleotide excision repair homolog (S. cerevisiae) | - | HPRD | 11279242 |
| MNAT1 | Mat1 |RNF66 |TFB3 | Menage A Trois同源物1，细胞周期蛋白H装配因子（Xenopus laevis） | - | HPRD，Biogrid | 12527756 |
| MPG | AAG | APNG | CRA36.1 | MDG | Mid1 | PIG11 | PIG16 | anpg | N-甲基丁胺-DNA糖基化酶 | ESR1（ER-Alpha）与MPG相互作用。 | 绑定 | 14761960 |
| MTA1 | - | metastasis associated 1 | - | HPRD，Biogrid | 12167865 |
| MVP | LRP |VAULT1 | 主要的金库蛋白 | - | HPRD，Biogrid | 9628887 |
| 我的C | bHLHe39 | c-Myc | V-myc骨髓质体病毒性癌基因同源物（禽类） | ER-Alpha与C-MYC启动子相互作用。 | 绑定 | 15808510 |
| NCAM2 | MGC51008 |NCAM21 | 神经细胞粘附分子2 | ER与NCAM2相互作用。 | 绑定 | 16009131 |
| NCOA1 | F-SRC-1 |kat13a |MGC129719 |MGC129720 |NCOA-1 |RIP160 |SRC-1 |src1 |Bhlhe42 | nuclear receptor coactivator 1 | ER-Alpha与SRC-1相互作用 | 绑定 | 10938099 |
| NCOA1 | F-SRC-1 |kat13a |MGC129719 |MGC129720 |NCOA-1 |RIP160 |SRC-1 |src1 |Bhlhe42 | nuclear receptor coactivator 1 | - | HPRD | 9427757|11165056 |
| NCOA1 | F-SRC-1 |kat13a |MGC129719 |MGC129720 |NCOA-1 |RIP160 |SRC-1 |src1 |Bhlhe42 | nuclear receptor coactivator 1 | Reconstituted Complex | BioGRID | 9427757|11003650 |11113179 |
| NCOA2 | GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2 | nuclear receptor coactivator 2 | ER Alpha与TIF2相互作用。这种相互作用是根据来自未指定源和人类alpha的TIF2之间的相互作用建模的。 | 绑定 | 10706629 |
| NCOA2 | GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2 | nuclear receptor coactivator 2 | - | HPRD，Biogrid | 11937504 |
| NCOA3 | Actr |AIB-1 |AIB1 |CAGH16 |CTG26 |kat13b |MGC141848 |Rac3 |src3 |TNRC14 | TNRC16 | TRAM-1 | pCIP | nuclear receptor coactivator 3 | - | HPRD，Biogrid | 11050174 |
| NCOA3 | Actr |AIB-1 |AIB1 |CAGH16 |CTG26 |kat13b |MGC141848 |Rac3 |src3 |TNRC14 | TNRC16 | TRAM-1 | pCIP | nuclear receptor coactivator 3 | src-3 interacts with ER. This interaction was modelled on a demonstrated interaction between human SRC-3 and ER from an unspecified species. | 绑定 | 15383283 |
| NCOA3 | Actr |AIB-1 |AIB1 |CAGH16 |CTG26 |kat13b |MGC141848 |Rac3 |src3 |TNRC14 | TNRC16 | TRAM-1 | pCIP | nuclear receptor coactivator 3 | TRAM-1与ER相互作用。 | 绑定 | 9346901 |
| NCOA4 | ARA70 |DKFZP762E1112 |ELE1 |PTC3 |RFG | nuclear receptor coactivator 4 | Reconstituted Complex | BioGRID | 9892017 |
| NCOA6 | AIB3 |antp |ASC2 |HOX1.1 |Hoxa7 |KIAA0181 |NRC |prip |Rap250 |trbp | nuclear receptor coactivator 6 | Reconstituted Complex 两个杂交 |
BioGRID | 10567404|11158331 |11773444 |
| NCOA7 | ERAP140 | ESNA1 | FLJ45605 | MGC88425 | Nbla00052 | Nbla10993 | dJ187J11.3 | nuclear receptor coactivator 7 | - | HPRD，Biogrid | 11971969 |
| NCOR1 | KIAA1047 |MGC104216 |n-cor |trac1 |HCIT529I10 |hn-cor | 核受体共抑制剂1 | - | HPRD，Biogrid | 12145334 |
| NCOR1 | KIAA1047 |MGC104216 |n-cor |trac1 |HCIT529I10 |hn-cor | 核受体共抑制剂1 | ESR1（ER-Alpha）与NCOR1（N-COR）相互作用。这种相互作用是基于未指定物种与人类NCOR1的ESR1之间的相互作用进行建模的。 | 绑定 | 12738788 |
| NCOR2 | CTG26 |SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 | 核受体共抑制剂2 | ESR1 (ER-alpha) interacts with NCOR2 (SMRT). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and NCOR2 from an unspecified species. | 绑定 | 12738788 |
| NCOR2 | CTG26 |SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 | 核受体共抑制剂2 | - | HPRD | 9702189 |
| NR0B2 | FLJ17090 |SHP |SHP1 | nuclear receptor subfamily 0, group B, member 2 | - | HPRD，Biogrid | 9773978|11861507 |
| NR2C1 | TR2 | 核受体亚科2，C组，成员1 | - | HPRD，Biogrid | 12093804 |
| NR2C2 | tak1 |tr2r1 |tr4 |htak1 | 核受体亚科2，C组，成员2 | - | HPRD，Biogrid | 11844790 |
| NR2F1 | COUP-TFI |ear-3 |Ear3 |erbal3 |NR2F2 |SVP44 |TCFCOUP1 |TFCOUP1 | nuclear receptor subfamily 2, group F, member 1 | - | HPRD，Biogrid | 12093745 |
| NR2F6 | EAR-2 | EAR2 | ERBAL2 | nuclear receptor subfamily 2, group F, member 6 | - | HPRD，Biogrid | 10713182 |
| NRIP1 | FLJ77253 | RIP140 | 核受体相互作用蛋白1 | ESR1 (ER-alpha) interacts with NRIP1 (RIP140). This interaction was modelled on a demonstrated interaction between human ESR1 and mouse NRIP1. | 绑定 | 9774463 |
| NRIP1 | FLJ77253 | RIP140 | 核受体相互作用蛋白1 | ER interacts with NRIP-1 enhancer. | 绑定 | 16009131 |
| NRIP1 | FLJ77253 | RIP140 | 核受体相互作用蛋白1 | - | HPRD，Biogrid | 7641693 |
| NSD1 | ARA267 |DKFZP666C163 |FLJ10684 |FLJ22263 |FLJ44628 |KMT3B |sotos |斯托 | nuclear receptor binding SET domain protein 1 | - | HPRD | 9628876 |
| PAK6 | PAK5 | P21蛋白（CDC42/RAC）激活激酶6 | - | HPRD，Biogrid | 11773441 |
| PELP1 | HMX3 |mnar |P160 | proline, glutamate and leucine rich protein 1 | - | HPRD，Biogrid | 11481323 |
| PGR | NR3C3 | PR | 孕酮受体 | ER-alpha interacts with the PgRA promoter. | 绑定 | 15019994 |
| PGR | NR3C3 | PR | 孕酮受体 | ER-alpha interacts with the PgRB promoter. | 绑定 | 15019994 |
| PHB2 | bap |BCAP37 |BAP37 |MGC117268 |PNAS-141 |Rea |p22 | 禁止素2 | ER-Alpha与Rea相互作用 | 绑定 | 10938099 |
| PHB2 | bap |BCAP37 |BAP37 |MGC117268 |PNAS-141 |Rea |p22 | 禁止素2 | 两个杂交 | BioGRID | 12943695 |
| PIAS1 | DDXBP1 |GBP |gu/rh-ii |MGC141878 |MGC141879 |Zmiz3 | protein inhibitor of activated STAT, 1 | ER-alpha interacts with PIAS1. | 绑定 | 15666801 |
| PIAS1 | DDXBP1 |GBP |gu/rh-ii |MGC141878 |MGC141879 |Zmiz3 | protein inhibitor of activated STAT, 1 | - | HPRD | 15666801 |
| PIAS2 | MGC102682 |Miz1 |piasx |piasx-alpha |piasx-beta |siz2 |zmiz4 |Miz | protein inhibitor of activated STAT, 2 | Reconstituted Complex | BioGRID | 11117529 |
| PIK3R1 | GRB1 | p85 | p85-ALPHA | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | - | HPRD，Biogrid | 11689445 |
| PNRC2 | FLJ20312 |MGC99541 | proline-rich nuclear receptor coactivator 2 | - | HPRD | 11574675 |
| POU2F1 | OCT1 | OTF1 | POU class 2 homeobox 1 | Reconstituted Complex | BioGRID | 10480874 |
| POU2F2 | OCT2 |OTF2 |10月2日 | POU class 2 homeobox 2 | Reconstituted Complex | BioGRID | 10480874 |
| POU4F1 | BRN3A | FLJ13449 | Oct-T1 | RDC-1 | POU class 4 homeobox 1 | Reconstituted Complex 两个杂交 |
BioGRID | 9448000 |
| POU4F2 | BRN3.2 | BRN3B | Brn-3b | POU class 4 homeobox 2 | - | HPRD，Biogrid | 9448000 |
| PPARGC1A | LEM6 | PGC-1(alpha) | PGC-1v | PGC1 | PGC1A | PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | - | HPRD，Biogrid | 10748020 |
| PPARGC1B | errl1 |Perc |PGC-1（beta）|PGC1B | peroxisome proliferator-activated receptor gamma, coactivator 1 beta | - | HPRD，Biogrid | 11854298 |
| PPID | CYP-40 | CYPD | MGC33096 | peptidylprolyl isomerase D | Reconstituted Complex | BioGRID | 9222609 |
| PRDM2 | Humhoxy1 |KMT8 |MTB-ZF |Riz |riz1 |RIZ2 | 包含2的PR域，带有ZNF域 | - | HPRD，Biogrid | 10706618 |
| PRMT1 | ANM1 |HCP1 |HRMT1L2 |IR1B4 | 蛋白精氨酸甲基转移酶1 | Reconstituted Complex | BioGRID | 11050077 |
| PRMT2 | HRMT1L1 |MGC111373 | 蛋白精氨酸甲基转移酶2 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 12039952 |
| PRMT2 | HRMT1L1 |MGC111373 | 蛋白精氨酸甲基转移酶2 | PRMT2与ER-Alpha相互作用。 | 绑定 | 12039952 |
| PRPF6 | ant-1 |C20orf14 |汤姆|U5-102K |HPRP6 | PRP6前MRNA处理因子6同源物（S. cerevisiae） | - | HPRD | 12039962 |
| PTEN | 10q23del | BZS | MGC11227 | MHAM | MMAC1 | PTEN1 | TEP1 | phosphatase and tensin homolog | Reconstituted Complex | BioGRID | 15205473 |
| PTGES3 | p23 |tebp |cpges | prostaglandin E synthase 3 (cytosolic) | Reconstituted Complex | BioGRID | 9222609 |
| PTGES3 | p23 |tebp |cpges | prostaglandin E synthase 3 (cytosolic) | - | HPRD | 10207098 |
| PTMA | MGC104802 |TMSA | prothymosin, alpha | Reconstituted Complex | BioGRID | 12943695 |
| RBM23 | Caperbeta |FLJ10482 |MGC4458 |pp239 |RNPC4 | RNA结合基序蛋白23 | RBM23（Caper-Beta）与ESR1（ER-Alpha）相互作用 | 绑定 | 15694343 |
| RBM39 | CAPER | CAPERalpha | CC1.3 | DKFZp781C0423 | FLJ44170 | HCC1 | RNPC2 | fSAP59 | RNA结合基序蛋白39 | - | HPRD，Biogrid | 11704680 |
| RBM9 | FOX2 |FOX-2 |HNRBP2 |HRNBP2 |RTA |DJ106I20.3 |FXH | RNA结合基序蛋白9 | - | HPRD，Biogrid | 11875103 |
| REXO4 | REX4 | XPMC2 | XPMC2H | REX4, RNA exonuclease 4 homolog (S. cerevisiae) | - | HPRD，Biogrid | 10908561 |
| RFX4 | NYD-SP10 | regulatory factor X, 4 (influences HLA class II expression) | - | HPRD | 1603086|10706293 |
| RNF14 | ARA54 | FLJ26004 | HFB30 | HRIHFB2038 | TRIAD2 | ring finger protein 14 | - | HPRD | 10085091 |
| RNF4 | RES4-26 | SNURF | ring finger protein 4 | 两个杂交 | BioGRID | 9710597 |
| SAFB | DKFZP779C1727 |哈普|het |SAFB1 | 脚手架依恋因子B | - | HPRD，Biogrid | 10707955 |
| SAFB2 | KIAA0138 | 脚手架附着因子B2 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 12660241 |
| SFI1 | MGC131712 | MGC150663 | MGC156283 | MGC57874 | PISD | RP5-858B16.1 | hSfi1p | SFI1同源物，主轴组件（酵母） | ER interacts with SFI1. | 绑定 | 16009131 |
| SHC1 | FLJ26504 | SHC | SHCA | SHC (Src homology 2 domain containing) transforming protein 1 | - | HPRD，Biogrid | 11773443 |
| SLC37A1 | FLJ22340 | G3PP | solute carrier family 37 (glycerol-3-phosphate transporter), member 1 | ER与SLC37A1相互作用。 | 绑定 | 16009131 |
| SMAD2 | JV18 |JV18-1 |madh2 |Madr2 |MGC22139 |MGC34440 |HMAD-2 |HSMAD2 | SMAD家庭成员2 | - | HPRD，Biogrid | 11555647 |
| Smarca2 | BAF190 |BRM |FLJ36757 |MGC74511 |SNF2 |snf2l2 |snf2la |swi2 |sth1p |hbrm | hSNF2a | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | - | HPRD，Biogrid | 9099865 |
| Smarca4 | BAF190 |BRG1 |FLJ39786 |SNF2 |snf2-beta |snf2l4 |SNF2LB |swi2 |HSNF2B | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | - | HPRD，Biogrid | 9099865 |
| Smarcd1 | BAF60A | CRACD1 | Rsc6p | SWI/SNF相关，矩阵相关，染色质的肌动蛋白依赖性调节剂，亚家族D，成员1 | Reconstituted Complex | BioGRID | 12917342 |
| SMARCE1 | BAF57 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | - | HPRD，Biogrid | 12145209 |
| snap29 | CEDNIK | FLJ21051 | SNAP-29 | 突触体相关蛋白，29KDA | ER与SNAP29相互作用。 | 绑定 | 16009131 |
| 鼻烟 | - | SNRPN upstream reading frame | 两个杂交 | BioGRID | 11696545 |
| SOD1 | ALS |ALS1 |IPOA |草皮|同二聚体 | superoxide dismutase 1, soluble | ER interacts with SOD-1 enhancer. | 绑定 | 16009131 |
| src | ASV | SRC1 | c-SRC | p60-Src | V-SRC肉瘤（Schmidt-Ruppin A-2）病毒癌基因同源物（Avian） | Affinity Capture-Western Reconstituted Complex |
BioGRID | 10454579|11032808 |11564893 |
| STAT3 | APRF |FLJ20882 |hies |MGC16063 | signal transducer and activator of transcription 3 (acute-phase response factor) | Affinity Capture-Western | BioGRID | 11429412 |
| Stat5a | MGF | STAT5 | signal transducer and activator of transcription 5A | ER-Alpha与STAT5A相互作用。 | 绑定 | 15304355 |
| Stat5a | MGF | STAT5 | signal transducer and activator of transcription 5A | Reconstituted Complex | BioGRID | 11682624 |
| STRN | MGC125642 | SG2NA | 纹状体，钙调蛋白结合蛋白 | - | HPRD | 15569929 |
| SVIL | DKFZP686A17191 | supervillin | 两个杂交 | BioGRID | 11792840 |
| tada3l | ADA3 |FLJ20221 |FLJ21329 |hada3 | 转录al adaptor 3 (NGG1 homolog, yeast)-like | - | HPRD，Biogrid | 12034840 |
| TAF10 | TAF2A | TAF2H | TAFII30 | TAF10RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | - | HPRD | 7923369 |
| TBP | gtf2d |GTF2D1 |MGC117320 |MGC126054 |MGC126055 |SCA17 |tfiid | 塔塔盒结合蛋白 | - | HPRD，Biogrid | 11595744 |
| TDG | - | 胸腺氨酸-DNA糖基酶 | - | HPRD，Biogrid | 12874288 |
| TFF1 | BCEI |D21S21 |HP1.A |HPS2 |PNR-2 |PS2 | 三叶因子1 | ER-Alpha与PS2相互作用。 | 绑定 | 10490106 |
| TFF1 | BCEI |D21S21 |HP1.A |HPS2 |PNR-2 |PS2 | 三叶因子1 | ER interacts with TFF-1 promoter. | 绑定 | 16009131 |
| TFF1 | BCEI |D21S21 |HP1.A |HPS2 |PNR-2 |PS2 | 三叶因子1 | ER与TFF-1增强子相互作用。 | 绑定 | 16009131 |
| TFF1 | BCEI |D21S21 |HP1.A |HPS2 |PNR-2 |PS2 | 三叶因子1 | ER-alpha interacts with the pS2 promoter. | 绑定 | 15304487 |
| thoc5 | C22orf19 | Fmip | PK1.3 | fSAP79 | 综合体5 | ER interacts with C22orf19. | 绑定 | 16009131 |
| TP53 | FLJ92943 |LFS1 |trp53 |p53 | 肿瘤蛋白p53 | - | HPRD，Biogrid | 10766163 |
| TP53 | FLJ92943 |LFS1 |trp53 |p53 | 肿瘤蛋白p53 | p53与ER-Alpha相互作用。 | 绑定 | 10766163 |
| TRIM24 | PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1 | 三方基序24 | Reconstituted Complex | BioGRID | 9115274|10598587 |
| TRIM24 | PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1 | 三方基序24 | - | HPRD | 9115274|9632676 |10598587 |
| TRIM24 | PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1 | 三方基序24 | ESR1（ER-Alpha）与TIF1相互作用。这种相互作用是在人ESR1和小鼠TIF1之间的相互作用上建模的。 | 绑定 | 9774463 |
| Trip4 | HST17391 | 甲状腺激素受体相互作用4 | - | HPRD，Biogrid | 10454579 |
| trrap | FLJ10671 |PAF350/400 |PAF400 |Staf40 |tr-ap |Tra1 | 转化/转录结构域相关蛋白 | ESR1（ER-Alpha）与TRRAP相互作用。这种相互作用是基于未指定物种的ESR1与未指定物种的TRRAP之间的相互作用进行建模的。 | 绑定 | 12738788 |
| trrap | FLJ10671 |PAF350/400 |PAF400 |Staf40 |tr-ap |Tra1 | 转化/转录结构域相关蛋白 | 亲和力捕获ms | BioGRID | 12837248 |
| ube2i | C358B7.1 | P18 | UBC9 | 泛素结合酶E2I（UBC9同源物，酵母） | ER-Alpha与UBC9的未指定同工型相互作用。 | 绑定 | 15666801 |
| XBP1 | TREB5 | XBP2 | X-box binding protein 1 | - | HPRD，Biogrid | 12954762 |
| XBP1 | TREB5 | XBP2 | X-box binding protein 1 | ER与XBP-1增强子相互作用。 | 绑定 | 16009131 |
| 是的 | ywha1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | - | HPRD | 11266503 |
| ywhaq | 14-3-3 |1c5 |HS1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | Reconstituted Complex | BioGRID | 11266503 |
| ZBTB16 | PLZF | ZNF145 | 锌指和包含16的BTB结构域 | - | HPRD，Biogrid | 14521715 |
| ZNF398 | KIAA1339 | P51 | P71 | ZER6 | 锌指蛋白398 | - | HPRD，Biogrid | 11779858 |
V.途径注释
| 路径名 | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA CARM ER PATHWAY | 35 | 27 | 该途径中的所有SZGR 2.0基因 |
| Biocarta MTA3途径 | 19 | 10 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA HER2 PATHWAY | 22 | 17 | 该途径中的所有SZGR 2.0基因 |
| PID SMAD2 3NUCLEAR PATHWAY | 82 | 63 | 该途径中的所有SZGR 2.0基因 |
| PID HDAC CLASSII PATHWAY | 34 | 27 | 该途径中的所有SZGR 2.0基因 |
| PID ER NONGENOMIC PATHWAY | 41 | 35 | 该途径中的所有SZGR 2.0基因 |
| PID LKB1 PATHWAY | 47 | 37 | 该途径中的所有SZGR 2.0基因 |
| PID端粒酶途径 | 68 | 48 | 该途径中的所有SZGR 2.0基因 |
| PID ATF2 PATHWAY | 59 | 43 | 该途径中的所有SZGR 2.0基因 |
| PID AP1 PATHWAY | 70 | 60 | 该途径中的所有SZGR 2.0基因 |
| PID FOXM1途径 | 40 | 30 | 该途径中的所有SZGR 2.0基因 |
| PID ERA GENOMIC PATHWAY | 65 | 37 | 该途径中的所有SZGR 2.0基因 |
| PID p38 alpha beta下游途径 | 38 | 29 | 该途径中的所有SZGR 2.0基因 |
| PID HNF3A PATHWAY | 44 | 29 | 该途径中的所有SZGR 2.0基因 |
| ERBB4的Reactome信号传导 | 90 | 67 | 该途径中的所有SZGR 2.0基因 |
| REACTOME NUCLEAR SIGNALING BY ERBB4 | 38 | 30 | 该途径中的所有SZGR 2.0基因 |
| Reactome通用转录途径 | 352 | 181 | 该途径中的所有SZGR 2.0基因 |
| Reactome核受体转录途径 | 49 | 36 | 该途径中的所有SZGR 2.0基因 |
| 周炎性反应活DN | 384 | 220 | 该途径中的所有SZGR 2.0基因 |
| 乳腺癌腔与基础 | 380 | 215 | 该途径中的所有SZGR 2.0基因 |
| 乳腺癌腔与间充质 | 450 | 256 | 该途径中的所有SZGR 2.0基因 |
| Doane乳腺癌ESR1 UP | 112 | 72 | 该途径中的所有SZGR 2.0基因 |
| BASAKI YBX1 TARGETS DN | 384 | 230 | 该途径中的所有SZGR 2.0基因 |
| 王攀登目标 | 269 | 146 | 该途径中的所有SZGR 2.0基因 |
| Ginestier乳腺癌Znf217扩增 | 78 | 48 | 该途径中的所有SZGR 2.0基因 |
| GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP | 119 | 66 | 该途径中的所有SZGR 2.0基因 |
| Elvidge缺氧DN | 146 | 94 | 该途径中的所有SZGR 2.0基因 |
| ELVIDGE HYPOXIA BY DMOG DN | 59 | 40 | 该途径中的所有SZGR 2.0基因 |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | 该途径中的所有SZGR 2.0基因 |
| GAUSSMANN MLL AF4 FUSION TARGETS A DN | 90 | 61 | 该途径中的所有SZGR 2.0基因 |
| RIZ红细胞分化12小时 | 43 | 35 | 该途径中的所有SZGR 2.0基因 |
| SCHEIDEREIT IKK TARGETS | 18 | 15 | 该途径中的所有SZGR 2.0基因 |
| FARMER BREAST CANCER APOCRINE VS LUMINAL | 326 | 213 | 该途径中的所有SZGR 2.0基因 |
| FARMER BREAST CANCER BASAL VS LULMINAL | 330 | 215 | 该途径中的所有SZGR 2.0基因 |
| JAERVINEN AMPLIFIED IN LARYNGEAL CANCER | 40 | 24 | 该途径中的所有SZGR 2.0基因 |
| LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN | 114 | 58 | 该途径中的所有SZGR 2.0基因 |
| DAWSON METHYLATED IN LYMPHOMA TCL1 | 59 | 45 | 该途径中的所有SZGR 2.0基因 |
| YANG BREAST CANCER ESR1 UP | 36 | 22 | 该途径中的所有SZGR 2.0基因 |
| HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BREAST CANCER LIT INT NETWORK | 101 | 73 | 该途径中的所有SZGR 2.0基因 |
| 成人癌中甲基化的欧姆 | 27 | 23 | 该途径中的所有SZGR 2.0基因 |
| Schaeffer前列腺开发48小时DN | 428 | 306 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | 该途径中的所有SZGR 2.0基因 |
| SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN | 36 | 24 | 该途径中的所有SZGR 2.0基因 |
| PENG GLUCOSE DEPRIVATION UP | 48 | 26 | 该途径中的所有SZGR 2.0基因 |
| BYSTRYKH造血干细胞QTL Trans | 882 | 572 | 该途径中的所有SZGR 2.0基因 |
| Weston Vegfa目标6小时 | 59 | 38 | 该途径中的所有SZGR 2.0基因 |
| 伊万诺娃造血干细胞 | 254 | 164 | 该途径中的所有SZGR 2.0基因 |
| WESTON VEGFA TARGETS | 108 | 71 | 该途径中的所有SZGR 2.0基因 |
| CUI TCF21目标2向上 | 428 | 266 | 该途径中的所有SZGR 2.0基因 |
| WESTON VEGFA TARGETS 3HR | 74 | 47 | 该途径中的所有SZGR 2.0基因 |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | 该途径中的所有SZGR 2.0基因 |
| LOPES METHYLATED IN COLON CANCER UP | 27 | 20 | 该途径中的所有SZGR 2.0基因 |
| Riggins他莫昔芬抵抗DN | 220 | 147 | 该途径中的所有SZGR 2.0基因 |
| MASSARWEH TAMOXIFEN RESISTANCE DN | 258 | 160 | 该途径中的所有SZGR 2.0基因 |
| 阿塞维多肝癌DN | 540 | 340 | 该途径中的所有SZGR 2.0基因 |
| 癌症中的甲基化 | 56 | 45 | 该途径中的所有SZGR 2.0基因 |
| 脑DN中的乳腺癌复发 | 85 | 58 | 该途径中的所有SZGR 2.0基因 |
| 骨骼中的Smid乳腺癌复发 | 97 | 61 | 该途径中的所有SZGR 2.0基因 |
| SMID乳腺癌腔内B | 172 | 109 | 该途径中的所有SZGR 2.0基因 |
| SMID BREAST CANCER LUMINAL A UP | 84 | 52 | 该途径中的所有SZGR 2.0基因 |
| SMID BREAST CANCER BASAL DN | 701 | 446 | 该途径中的所有SZGR 2.0基因 |
| TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | 该途径中的所有SZGR 2.0基因 |
| Buckanovich t淋巴细胞在肿瘤上 | 24 | 11 | 该途径中的所有SZGR 2.0基因 |
| MATZUK排卵前卵泡 | 10 | 8 | 该途径中的所有SZGR 2.0基因 |
| Boquest干细胞培养与新鲜 | 425 | 298 | 该途径中的所有SZGR 2.0基因 |
| 西肾上腺皮质肿瘤DN | 546 | 362 | 该途径中的所有SZGR 2.0基因 |
| VANTVEER BREAST CANCER ESR1 UP | 167 | 99 | 该途径中的所有SZGR 2.0基因 |
| Shedden肺癌良好生存A4 | 196 | 124 | 该途径中的所有SZGR 2.0基因 |
| JISON SICKLE CELL DISEASE DN | 181 | 97 | 该途径中的所有SZGR 2.0基因 |
| POOLA浸润性乳腺癌DN | 134 | 83 | 该途径中的所有SZGR 2.0基因 |
| YAMASHITA LIVER CANCER STEM CELL UP | 47 | 38 | 该途径中的所有SZGR 2.0基因 |
| Yamashita肝癌干细胞DN | 76 | 51 | 该途径中的所有SZGR 2.0基因 |
| Li前列腺癌表观遗传 | 30 | 22 | 该途径中的所有SZGR 2.0基因 |
| PYEON CANCAR CANCAR HEAD和NECK与颈椎 | 193 | 95 | 该途径中的所有SZGR 2.0基因 |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2 | 86 | 50 | 该途径中的所有SZGR 2.0基因 |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 3 | 15 | 7 | 该途径中的所有SZGR 2.0基因 |
| 金双相情感障碍少突胶质细胞密度cor dn | 88 | 59 | 该途径中的所有SZGR 2.0基因 |
| Acosta增殖独立MYC目标DN | 116 | 74 | 该途径中的所有SZGR 2.0基因 |
| BHAT ESR1不是通过AKT1 DN的目标 | 88 | 61 | 该途径中的所有SZGR 2.0基因 |
| BHAT ESR1 TARGETS VIA AKT1 DN | 82 | 51 | 该途径中的所有SZGR 2.0基因 |
| Servitja肝HNF1A靶向DN | 157 | 105 | 该途径中的所有SZGR 2.0基因 |
| ERBB2同工型的Pedersen转移7 | 403 | 240 | 该途径中的所有SZGR 2.0基因 |
| Wang MLL目标 | 289 | 188 | 该途径中的所有SZGR 2.0基因 |
| 林乳腺干细胞DN | 428 | 246 | 该途径中的所有SZGR 2.0基因 |
| LIM MAMMARY LUMINAL MATURE UP | 116 | 65 | 该途径中的所有SZGR 2.0基因 |
| FARMER BREAST CANCER CLUSTER 6 | 16 | 13 | 该途径中的所有SZGR 2.0基因 |
Section VI. microRNA annotation
| mirna家族 | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| mir-130/301 | 3766 | 3772 | M8 | HSA-MIR-130Abrain | cagugcaauguaaaaggggau |
| hsa-miR-301 | CAGUGCAAUAGUAUUGUCAAAGC | ||||
| HSA-MIR-130bbrain | Cagugcaaugaagggauggau | ||||
| HSA-MIR-454-3P | UAGUGCAAUAUUGCUUAUAGGGUUU | ||||
| miR-148/152 | 3767 | 3773 | M8 | hsa-miR-148a | UCAGUGCACUACAGAACUUUGU |
| hsa-miR-152brain | UCAGUGCAUGACAGAACUUGGG | ||||
| hsa-miR-148b | ucagugcaucacacaacuuugu | ||||
| mir-18 | 1938年 | 1945年 | 1A，M8 | hsa-miR-18a | UAAGGUGCAUCUAGUGCAGAUA |
| hsa-miR-18b | uaaggugcaucuagugcagua | ||||
| mir-181 | 1998 | 2005 | 1A，M8 | HSA-MIR-181Abrain | AACAUUCAACGCUGUCGGUGAGU |
| HSA-MIR-181BSZ | AACAUUCAUUGCUGUCGGUGGG | ||||
| HSA-MIR-181Cbrain | AACAUUCAACCUGUCGGUGAGU | ||||
| HSA-MIR-181Dbrain | AACAUUCAUUGUUGUCGGUGGGUU | ||||
| mir-188 | 196 | 202 | M8 | hsa-miR-188 | CAUCCCUUGCAUGGUGGAGGGU |
| mir-19 | 4216 | 4222 | M8 | hsa-miR-19a | ugugcaaauaugauaugaaaacuga |
| hsa-miR-19b | UGUGCAAAUCCAUGCAAAACUGA | ||||
| hsa-miR-19a | ugugcaaauaugauaugaaaacuga | ||||
| hsa-miR-19b | UGUGCAAAUCCAUGCAAAACUGA | ||||
| mir-203.1 | 2165 | 2172 | 1A，M8 | HSA-MIR-203 | ugaaauguuuaggaccacuag |
| miR-204/211 | 195 | 201 | M8 | HSA-MIR-204brain | UUCCCUUUGUCAUCCUAUGCCU |
| HSA-MIR-211 | UUCCCUUUGUCAUCCUUCGCCU | ||||
| mir-219 | 2244 | 2250 | M8 | HSA-MIR-219brain | ugauuguccaaacgcaauucu |
| mir-22 | 2292 | 2299 | 1A，M8 | HSA-MIR-22brain | Aagcugccaguugaagaacugu |
| mir-221/222 | 2253 | 2260 | 1A，M8 | HSA-MIR-221brain | AGCUACAUUGUCUGCUGGGUUUC |
| HSA-MIR-222brain | agcuacaucuggcuacugggucuc | ||||
| mir-26 | 3982 | 3988 | 1A | HSA-MIR-26Abrain | UUCAAGUAAUCCAGGAUAGGC |
| HSA-MIR-26BSZ | uucaaguaauucaggauagguu | ||||
| miR-330 | 4182 | 4188 | M8 | hsa-miR-330brain | GCAAAGCACGGCCUGCAGAGA |
| mir-361 | 3233 | 3239 | 1A | hsa-miR-361brain | UUAUCAGAAUCUCCAGGGGUAC |
| miR-496 | 3841 | 3847 | 1A | HSA-MIR-496 | Auuacauggccaaucuc |
| miR-9 | 3086 | 3092 | 1A | HSA-MIR-9SZ | ucuuuguuaucuagcuguauga |
| mir-93.hd/291-3p/294/295/302/372/373/520 | 379 | 385 | M8 | HSA-MIR-93brain | aaagugcuguucgugcagguag |
| hsa-miR-302a | UAAGUGCUUCCAUGUUUUGGUGA | ||||
| hsa-miR-302b | uaagugcuuccauguuuaguag | ||||
| hsa-miR-302c | uaagugcuuccauguucagugg | ||||
| hsa-miR-302d | Uaagugcuauguugugugu | ||||
| hsa-miR-372 | aaagugcugcgacauuugagcgu | ||||
| hsa-miR-373 | GAAGUGCUUCGAUUUUGGGGUGU | ||||
| HSA-MIR-520E | AAAGUGCUUCCUUUUUGAGGG | ||||
| hsa-miR-520a | aaagugcuucccuuguggugu | ||||
| hsa-miR-520b | AAAGUGCUUCCUUUUAGAGGG | ||||
| hsa-miR-520c | aaagugcuuuuuuaggggug | ||||
| hsa-miR-520d | AAAGUGCUUCUCUUUGGUGGGUU | ||||