基因页：ESR2
概括?
| 基因ID | 2100 |
| Symbol | ESR2 |
| 同义词 | ER-BETA|ESR-BETA|ESRB|ESTRB|Erb|NR3A2 |
| 描述 | estrogen receptor 2 (ER beta) |
| 参考 | MIM:601663|HGNC：HGNC：3468|Ensembl:ENSG00000140009|HPRD:03390|Vega:OTTHUMG00000141306 |
| 基因type | protein-coding |
| 地图位置 | 14q23.2 |
| Pascal P值 | 0.178 |
| TADA P值 | 0.011 |
| Fetal beta | 0.069 |
| 支持 | COMPOSITESET |
数据源中的基因
| 基因set name | 基因组方法 | 描述 | Info |
|---|---|---|---|
| DNM：Fromer_2014 | 整个外显子组测序分析 | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. | |
| PMID:cooccur | 高通量文献搜索 | 系统的海rch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Expression | 基因表达的荟萃分析 | P价值：1.461 | |
| 文学 | 高通量文献搜索 | 与精神分裂症关键词共同存在：精神分裂症，精神分裂症 | Click to show details |
| 网络 | 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 | PPI网络中最短路径的贡献：0.0521 |
第一节遗传学和表观遗传学注释
DNM table
DNM table| 基因 | Chromosome | Position | Ref | Alt | Transcript | AA更改 | 突变类型 | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ESR2 | chr14 | 64735576 | G | A | NM_001040275 NM_001214902 NM_001214903 NM_001271876 NM_001271877 NM_001437 NR_073496 NR_073497 NR_073505 |
p.197r> w p.197r> w p.197r> w p.197r> w p.197r> w p.197r> w . . . |
错过 错过 错过 错过 错过 错过 npcRNA npcRNA npcRNA |
精神分裂症 | DNM：Fromer_2014 |
Section II. Transcriptome annotation
基因ral gene expression (GTEx)
Devlopment期间的基因表达（BrainCloud）
脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。
基因expression of temporal and spatial changes (BrainSpan)
脚注：
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| 基因 | 皮尔逊的相关性 | Spearman's Correlation |
| FNDC3A | 0.78 | 0.86 |
| FAF2 | 0.76 | 0.82 |
| IMPAD1 | 0.75 | 0.83 |
| EAF1 | 0.75 | 0.82 |
| MAP3K7IP2 | 0.74 | 0.81 |
| SLC39A9 | 0.74 | 0.81 |
| mmgt1 | 0.74 | 0.80 |
| DCTN4 | 0.74 | 0.80 |
| SEC23B | 0.74 | 0.78 |
| ZFR | 0.73 | 0.80 |
| 前10个负共表达基因 | ||
| 基因 | 皮尔逊的相关性 | Spearman's Correlation |
| FXYD1 | -0.59 | -0.62 |
| MT-CO2 | -0.56 | -0.60 |
| AF347015.21 | -0.55 | -0.60 |
| higd1b | -0.55 | -0.60 |
| CSAG1 | -0.54 | -0.57 |
| AC098691.2 | -0.54 | -0.62 |
| IFI27 | -0.53 | -0.57 |
| AF347015.8 | -0.53 | -0.58 |
| AF347015.31 | -0.52 | -0.58 |
| AF347015.33 | -0.52 | -0.55 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| 去：0003700 | 转录因子活性 | 塔斯 | 8769313 | |
| 去：0003713 | transcription coactivator activity | 塔斯 | 8769313 | |
| GO:0005496 | steroid binding | 塔斯 | 11181953 | |
| GO:0005515 | protein binding | 新闻学会 | 12039952|14764652 | |
| 去：0008270 | zinc ion binding | IEA | - | |
| GO:0048019 | 受体拮抗剂活性 | NAS | 9671811 | |
| GO：0030284 | 雌激素受体活性 | 塔斯 | 11181953 | |
| GO:0046872 | 金属离子结合 | IEA | - | |
| GO：0043565 | 序列特异性DNA结合 | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006355 | regulation of transcription, DNA-dependent | 塔斯 | 11181953 | |
| GO:0030520 | 雌激素受体信号通路 | 塔斯 | 11181953 | |
| GO:0006350 | transcription | IEA | - | |
| GO:0007267 | cell-cell signaling | 塔斯 | 8769313 | |
| 去：0007165 | signal transduction | 塔斯 | 8769313|10749889 | |
| GO:0030308 | negative regulation of cell growth | NAS | 11181953 | |
| 细胞分量 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | 核 | 塔斯 | 11181953 | |
| GO:0005739 | 线粒体 | 艾达 | 15024130 |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| BCAS2 | 大坝1 | 乳腺癌扩增序列2 | BCAS2 interacts with ER-beta. This interaction was modeled on a demonstrated interaction between human BCAS2 and ER-beta from an unspecified species. | BIND | 15694360 |
| 平静1 | Calml2 |CAMI |DD132 |PHKD | calmodulin 1 (phosphorylase kinase, delta) | - | HPRD | 11981030 |
| CALM2 | CAMII | PHKD | PHKD2 | calmodulin 2 (phosphorylase kinase, delta) | - | HPRD | 11981030 |
| CALM3 | PHKD |PHKD3 | 钙调蛋白3（磷酸化酶激酶，三角洲） | - | HPRD | 11981030 |
| DAP3 | DAP-3 | DKFZp686G12159 | MGC126058 | MGC126059 | MRP-S29 | MRPS29 | bMRP-10 | 死亡相关蛋白3 | Reconstituted Complex | BioGRID | 10903152 |
| DDX54 | DP97 | MGC2835 | 死亡（ASP-GLU-ALA-ASP）盒多肽54 | - | HPRD，Biogrid | 12466272 |
| DNTTIP2 | ERBP |FCF2 |HSU15552 |LPTS-RP2 |MGC163494 |RP4-561L24.1 |TDIF2 | 脱氧核苷酸转移酶，末端，相互作用蛋白2 | - | HPRD，Biogrid | 15047147 |
| ESR1 | DKFZP686N23123 |er |ESR |Esra |时代|NR3A1 | 雌激素受体1 | ER alpha interacts with ER beta to form heterodimer. This interaction was modeled on a demonstrated interaction between human ER alpha and mouse ER beta. | BIND | 10706629 |
| ESR1 | DKFZP686N23123 |er |ESR |Esra |时代|NR3A1 | 雌激素受体1 | - | HPRD，Biogrid | 9473491 |
| MAD2L1 | HSMAD2 | MAD2 | MAD2 mitotic arrest deficient-like 1 (yeast) | MAD2 interacts with ER beta. This interaction was modeled on a demonstrated interaction between MAD2 from human and sheep and ER beta from rat and mouse. | BIND | 10706629 |
| MAD2L1 | HSMAD2 | MAD2 | MAD2 mitotic arrest deficient-like 1 (yeast) | - | HPRD，Biogrid | 10706629 |
| MED1 | CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2 | mediator complex subunit 1 | - | HPRD，Biogrid | 11867769 |
| MKNK2 | GPRK7 | MNK2 | MAP kinase interacting serine/threonine kinase 2 | - | HPRD，Biogrid | 11013076 |
| MMS19 | FLJ34167 | FLJ95146 | MET18 | MGC99604 | MMS19L | hMMS19 | MMS19 nucleotide excision repair homolog (S. cerevisiae) | - | HPRD | 11279242 |
| NCOA1 | F-SRC-1 |kat13a |MGC129719 |MGC129720 |NCOA-1 |RIP160 |SRC-1 |src1 |Bhlhe42 | nuclear receptor coactivator 1 | - | HPRD，Biogrid | 10809226 |
| NCOA3 | ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIP | nuclear receptor coactivator 3 | - | HPRD，Biogrid | 10681591|11389589 |
| NCOA6 | AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBP | nuclear receptor coactivator 6 | - | HPRD，Biogrid | 11773444 |
| NR0B2 | FLJ17090 | SHP | SHP1 | nuclear receptor subfamily 0, group B, member 2 | - | HPRD，Biogrid | 9773978|10648597 |
| 牛 | MGC126890 | MGC126892 | OT | OT-NPI | oxytocin, prepropeptide | - | HPRD | 9501254 |
| PELP1 | HMX3 |mnar |P160 | proline, glutamate and leucine rich protein 1 | - | HPRD，Biogrid | 12415108 |
| PIAS2 | MGC102682 | MIZ1 | PIASX | PIASX-ALPHA | PIASX-BETA | SIZ2 | ZMIZ4 | miz | 活化统计的蛋白质抑制剂2 | Reconstituted Complex | BioGRID | 11117529 |
| PRMT2 | HRMT1L1 | MGC111373 | protein arginine methyltransferase 2 | PRMT2与ER-BETA相互作用。 | BIND | 12039952 |
| PSMC3IP | GT198 | HOP2 | HUMGT198A | TBPIP | PSMC3 interacting protein | - | HPRD | 11739747 |
| RBM39 | 刺山|Caperalpha |CC1.3 |DKFZP781C0423 |FLJ44170 |HCC1 |RNPC2 |FSAP59 | RNA binding motif protein 39 | - | HPRD，Biogrid | 11704680 |
| RBM9 | FOX2 |FOX-2 |HNRBP2 |HRNBP2 |RTA |DJ106I20.3 |FXH | RNA binding motif protein 9 | - | HPRD，Biogrid | 11875103 |
| REXO4 | rex4 |XPMC2 |XPMC2H | REX4，RNA外切酶4同源物（S. cerevisiae） | - | HPRD，Biogrid | 10908561 |
| SMARCE1 | BAF57 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | - | HPRD，Biogrid | 12145209 |
| SRC | ASV |src1 |C-SRC |P60-SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Affinity Capture-Western | BioGRID | 11032808 |
| Stat5a | MGF |Stat5 | signal transducer and activator of transcription 5A | - | HPRD，Biogrid | 11682624 |
| TRIM24 | PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1 | tripartite motif-containing 24 | - | HPRD | 10598587 |
| 是的 | ywha1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | - | HPRD | 11266503 |
| ywhaq | 14-3-3 | 1C5 | HS1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | Reconstituted Complex | BioGRID | 11266503 |
V.途径注释
| Pathway name | Pathway size | ＃szgr 2.0基因 | Info |
|---|---|---|---|
| PID ER非原始组途径 | 41 | 35 | 该途径中的所有SZGR 2.0基因 |
| PID ERB基因组途径 | 15 | 8 | 该途径中的所有SZGR 2.0基因 |
| PID时代基因组途径 | 65 | 37 | 该途径中的所有SZGR 2.0基因 |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | 该途径中的所有SZGR 2.0基因 |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 49 | 36 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
| LI CYTIDINE ANALOGS CYCTOTOXICITY | 15 | 8 | 该途径中的所有SZGR 2.0基因 |
| LOPES METHYLATED IN COLON CANCER UP | 27 | 20 | 该途径中的所有SZGR 2.0基因 |
| HILLION HMGA1 TARGETS | 90 | 71 | 该途径中的所有SZGR 2.0基因 |
| MATZUK PREOVULATORY FOLLICLE | 10 | 8 | 该途径中的所有SZGR 2.0基因 |
| Yoshimura mapk8靶向 | 1305 | 895 | 该途径中的所有SZGR 2.0基因 |
| Mikkelsen MCV6 ICP，带有H3K4ME3和H3K27ME3 | 34 | 21 | 该途径中的所有SZGR 2.0基因 |
| MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 | 126 | 83 | 该途径中的所有SZGR 2.0基因 |
| Li前列腺癌表观遗传 | 30 | 22 | 该途径中的所有SZGR 2.0基因 |
| 钱德兰转移 | 221 | 135 | 该途径中的所有SZGR 2.0基因 |
| Sengupta EBNA1反相关 | 173 | 85 | 该途径中的所有SZGR 2.0基因 |