Gene Page:ETF1

Summary？
基因 2107
象征 ETF1
Synonyms D5S1995 | ERF | ERF1 | RF1 | SUP45L1 | TB3-1
Description 真核翻译终止因子1
Reference MIM：600285|HGNC:HGNC:3477|Ensembl：ENSG00000120705|HPRD：02616|Vega:OTTHUMG00000129199
基因类型 蛋白质编码
Map location 5Q31.1
pascal p-value 2.412E-7
Sherlock p-value 0.373
胎儿β -0.811

Gene in Data Sources
基因集名称 Method of gene set Description 信息
简历：Gwascat Genome-wide Association Studies 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
简历：PGC128 全基因组关联研究 A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp 全基因组关联研究 GWAS
GSMA_I Genome scan meta-analysis PSR：0.0032
表达 Meta-analysis of gene expression p价值：1.79
Network Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献：0.0278

Section I. Genetics and epigenetics annotation

@简历：PGC128

SNP ID 染色体 位置 等位基因 p 功能 Gene 向上/向下距离
RS3849046 CHR5 137851192 TC 4.833e-9 intronic ETF1


第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene pearson's Correlation 斯皮尔曼的相关性
MDS1 1.00 1.00
FLI1 0.82 0.80
itga1 0.81 0.82
COBLL1 0.77 0.78
OCLN 0.76 0.78
FGD5 0.75 0.78
ETS1 0.75 0.80
TEK 0.75 0.77
TGFBR2 0.73 0.79
CDH5 0.73 0.73
Top 10 negatively co-expressed genes
Gene pearson's Correlation 斯皮尔曼的相关性
RPS21 -0.38 -0.45
FAM128A -0.37 -0.35
MRPL52 -0.37 -0.38
SNHG12 -0.36 -0.36
RPL31 -0.36 -0.43
C12orf45 -0.36 -0.37
ATP5E -0.36 -0.41
bloc1s1 -0.36 -0.35
ST20 -0.36 -0.36
AC008763.1 -0.35 -0.40

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0003723 RNA结合 TAS 7990965
去：0005515 蛋白质结合 IPI 9620853|9712840
GO：0016149 翻译释放因子活动，密码子特异性 IEA -
去：0043022 核糖体结合 TAS 12867083
生物过程 去学期 证据 神经关键字 PubMed ID
去：0006449 翻译终止调节 TAS 7990965
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005737 cytoplasm TAS 7990965

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Reactome翻译 222 75 All SZGR 2.0 genes in this pathway
蛋白质的反应组代谢 518 242 All SZGR 2.0 genes in this pathway
mRNA的反应组代谢 284 128 All SZGR 2.0 genes in this pathway
READEM RNA的代谢 330 155 All SZGR 2.0 genes in this pathway
反应组胡说八道介导的衰减由外显子连接络合物增强 176 57 All SZGR 2.0 genes in this pathway
Gary CD5目标DN 431 263 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
轮藻FE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
Tien肠益生菌6小时DN 167 100 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
Elvidge缺氧DN 146 94 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡 1781 1082 All SZGR 2.0 genes in this pathway
Graessmann对MC和阿霉素DN的反应 770 415 All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment 536 340 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
dirmeier LMP1响应迟到 57 41 All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络 1652 1023 All SZGR 2.0 genes in this pathway
带有E盒的WEI MYCN目标 795 478 All SZGR 2.0 genes in this pathway
SCIAN INVERSED TARGETS OF TP53 AND TP73 DN 31 23 All SZGR 2.0 genes in this pathway
Benporath Myc Max目标 775 494 All SZGR 2.0 genes in this pathway
Shepard粉碎和燃烧突变体 197 110 All SZGR 2.0 genes in this pathway
pENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
Bystroem与IL5 UP相关 51 30 All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN 309 206 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
彭雷帕霉素反应dn 245 154 All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者 555 346 All SZGR 2.0 genes in this pathway
Nemeth炎症反应LPS 88 64 All SZGR 2.0 genes in this pathway
伊万诺娃造血晚期祖先 544 307 All SZGR 2.0 genes in this pathway
Sesto对UV C1的反应 72 45 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
霍林引用1个目标2 dn 17 11 All SZGR 2.0 genes in this pathway
由FOXP3绑定的Marson刺激 1022 619 All SZGR 2.0 genes in this pathway
促进耐受巨噬细胞 156 92 All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上 863 514 All SZGR 2.0 genes in this pathway
Yagi AML带有Inv 16易位 422 277 All SZGR 2.0 genes in this pathway
MARSON FOXP3目标DN 54 38 All SZGR 2.0 genes in this pathway
GUTIERREZ MULTIPLE MYELOMA UP 35 24 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
YAO对孕酮簇7的时间反应7 76 46 All SZGR 2.0 genes in this pathway
Thillainadesan Znf217靶向 44 22 All SZGR 2.0 genes in this pathway
Bruins通过TP53组C的UVC响应 92 60 All SZGR 2.0 genes in this pathway
Lee BMP2靶向DN 882 538 All SZGR 2.0 genes in this pathway
Huang GATA2靶向DN 72 52 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-124.1 88 94 M8 HSA-MIR-124A UUAAGGCACGCGGUGAAUGCCA
miR-124/506 88 94 1a hsa-miR-506 uaaggcacccuucugugaguaga
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-134 1481 1487 M8 HSA-MIR-134brain ugugacuggugaccagaggg
miR-136 2177 2184 1A，M8 HSA-MIR-136 Acuccauuuuuuugaugaugaugga
miR-150 832 839 1A，M8 HSA-MIR-150 UCUCCCAACCCUUGUACCAGUG
miR-17-5p/20/93.mr/106/519.d 1442 1448 1a HSA-MIR-17-5P caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ caaagugcuugugcagguag
HSA-MIR-519D caaagugccucccuuuagugugu
miR-181 962 968 M8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ aacauucauugcugucggggg
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain aacauucauuguugucggggguggguu
miR-182 1966 1972 1a HSA-MIR-182 uuuggcaaugguagaacucaca
miR-186 1982 1988 1a HSA-MIR-186 caaagaauuuugggcuu
miR-200bc/429 2187 2193 1a hsa-miR-200b uaauacugccugguaaugaugac
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
mir-205 1349 1355 1a hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
mir-216 952 959 1A，M8 hsa-miR-216 uaaucucagcuggcaacugug
miR-23 959 965 1a HSA-MIR-23Abrain AUCACAUUGCCAGGGAUUUCC
HSA-MIR-23Bbrain AUCACAUUGCCAGGGAUUACC
miR-26 1564 1570 1a HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU
mir-299-5p 2192 2198 1a hsa-miR-299-5p ugguuuaccgucccacauacau
hsa-miR-299-5p ugguuuaccgucccacauacau
mir-320 1492 1498 1a hsa-miR-320 aaaagcugggugagaggggcgaa
miR-324-3p 447 453 1a hsa-miR-324-3p CCACUGCCCCAGGUGCUGCUGG
mir-326 1849 1855 1a hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
mir-329 2034 2040 1a hsa-miR-329brain aacacaccugguaaccucuuu
mir-330 1733 1739 M8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
mir-335 292 298 M8 hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUAUGU
miR-34b 1536 1542 1a hsa-miR-34b uaggcagugucauagcugauug
miR-381 295 301 M8 HSA-MIR-381 uauacaagggcaagcucucugu
mir-410 2022 2028 1a hsa-miR-410 aauauaacacagauggcugu
miR-490 1523 1530 1A，M8 HSA-MIR-490 caaccuggaggacuaugcugcug
miR-493-5p 2168 2174 M8 HSA-MIR-493-5p uuguacaugguaggcuuucauu
miR-496 1590年 1596年 1a HSA-MIR-496 Auuacauggccaaucuc
HSA-MIR-496 Auuacauggccaaucuc
mir-505 545 551 1a hsa-miR-505 gucaacuugcugguuccuc
mir-543 963 969 M8 hsa-miR-543 aaacauucgcggugcacuucu
mir-544 1756 1762 M8 hsa-miR-544 auucugcauuuuuuagcaagu
mir-96 1966 1972 1a HSA-MIR-96brain uuuggcacuagcacauuuuugc