Gene Page:ALAS2

Summary?
GeneID 212
Symbol ALAS2
Synonyms ALAS-E|ALASE|ANH1|ASB|XLDPP|XLEPP|XLSA
Description 5'-aminolevulinate synthase 2
Reference MIM:301300|HGNC:HGNC:397|Ensembl:ENSG00000158578|HPRD:02356|Vega:OTTHUMG00000021641
Gene type protein-coding
Map location Xp11.21
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2762819 chr1 52798032 ALAS2 212 0.15 trans
rs7538562 chr1 59277182 ALAS2 212 0.04 trans
rs2811849 chr1 59300272 ALAS2 212 0.14 trans
rs2811850 chr1 59312340 ALAS2 212 0.14 trans
rs2272792 chr1 166829521 ALAS2 212 1.638E-4 trans
rs6543264 chr2 105270432 ALAS2 212 2.924E-5 trans
rs12468303 chr2 181613256 ALAS2 212 0.11 trans
rs16867364 chr2 181624945 ALAS2 212 0.2 trans
rs6442062 chr3 47243234 ALAS2 212 0.12 trans
rs295432 chr3 47361887 ALAS2 212 0 trans
rs1545329 chr4 95912889 ALAS2 212 8.034E-4 trans
rs2120832 chr4 95924906 ALAS2 212 0.02 trans
rs1444920 chr4 95925993 ALAS2 212 0.02 trans
rs9326981 chr5 115320607 ALAS2 212 0.1 trans
rs12524113 chr6 38679547 ALAS2 212 5.033E-7 trans
rs17712118 chr6 70808553 ALAS2 212 0.1 trans
rs9484130 chr6 138547963 ALAS2 212 0.04 trans
rs6907613 chr6 138548270 ALAS2 212 0.09 trans
rs11007270 chr10 29146063 ALAS2 212 0.16 trans
rs266080 chr10 44833893 ALAS2 212 0.17 trans
rs7488206 chr12 49784155 ALAS2 212 0.13 trans
rs12422793 chr12 125892834 ALAS2 212 0.09 trans
rs7323925 chr13 24217159 ALAS2 212 0.19 trans
snp_a-1785245 0 ALAS2 212 0.05 trans
rs4566169 chr16 911716 ALAS2 212 0.15 trans
rs274094 chr16 24910476 ALAS2 212 0.15 trans
rs6029091 chr20 39016259 ALAS2 212 0.11 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TELO2 0.90 0.89
ARVCF 0.90 0.88
DTX1 0.90 0.89
WIZ 0.89 0.89
FZR1 0.89 0.87
GLT25D1 0.89 0.87
ZNF446 0.89 0.90
SARM1 0.88 0.86
RFX1 0.88 0.90
GTPBP3 0.88 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.70 -0.70
AF347015.31 -0.68 -0.74
AF347015.27 -0.67 -0.73
MT-CO2 -0.65 -0.72
AF347015.33 -0.65 -0.71
MT-CYB -0.63 -0.70
S100B -0.63 -0.67
ACOT13 -0.62 -0.65
AF347015.21 -0.62 -0.77
B2M -0.61 -0.65

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCINE SERINE AND THREONINE METABOLISM 31 26 All SZGR 2.0 genes in this pathway
KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM 41 23 All SZGR 2.0 genes in this pathway
BIOCARTA AHSP PATHWAY 13 6 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PORPHYRINS 14 7 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 78 41 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP 98 58 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 79 54 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 65 44 All SZGR 2.0 genes in this pathway
WELCH GATA1 TARGETS 22 12 All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA DN 26 16 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151 103 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293 160 All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 106 68 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 149 85 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 DN 40 22 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225 124 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 149 85 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 116 74 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
VANDESLUIS NORMAL EMBRYOS DN 25 13 All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 UP 115 73 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157 105 All SZGR 2.0 genes in this pathway