Gene Page:EXT2
Summary?
| GeneID | 2132 |
| Symbol | EXT2 |
| Synonyms | SOTV|SSMS |
| Description | exostosin glycosyltransferase 2 |
| Reference | MIM:608210|HGNC:HGNC:3513|Ensembl:ENSG00000151348|HPRD:00599|Vega:OTTHUMG00000166498 |
| Gene type | protein-coding |
| Map location | 11p12-p11 |
| Pascal p-value | 0.028 |
| eGene | Myers' cis & trans 元 |
| Support | G2Cdb.humanPSD G2Cdb.humanPSP Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4741017 | chr9 | 10204525 | EXT2 | 2132 | 0.02 | trans | ||
| rs4570782 | chr15 | 95576903 | EXT2 | 2132 | 0.17 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CILP | 0.55 | 0.40 |
| FGFR4 | 0.53 | 0.39 |
| MYO19 | 0.52 | 0.44 |
| PXDN | 0.51 | 0.36 |
| CEACAM19 | 0.49 | 0.40 |
| HPX | 0.49 | 0.33 |
| CCNL2 | 0.49 | 0.40 |
| RAD52 | 0.48 | 0.40 |
| ZNF692 | 0.48 | 0.45 |
| FSCN3 | 0.48 | 0.36 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.28 | -0.34 |
| S100A16 | -0.28 | -0.32 |
| APOE | -0.28 | -0.34 |
| HSD17B6 | -0.27 | -0.31 |
| AIFM3 | -0.27 | -0.28 |
| AC011427.1 | -0.26 | -0.30 |
| AF347015.33 | -0.26 | -0.31 |
| AF347015.27 | -0.26 | -0.33 |
| MT-CYB | -0.26 | -0.32 |
| COX4I2 | -0.26 | -0.31 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CLEC2L | FLJ32986 | C-type lectin domain family 2, member L | Affinity Capture-MS | BioGRID | 17353931 |
| 据 | HCNTF | ciliary neurotrophic factor | Affinity Capture-MS | BioGRID | 17353931 |
| CRB1 | LCA8 | RP12 | crumbs homolog 1 (Drosophila) | Affinity Capture-MS | BioGRID | 17353931 |
| EXT1 | EXT | LGCR | LGS | TRPS2 | ttv | exostoses (multiple) 1 | - | HPRD,BioGRID | 10639137|10679296 |
| EXT2 | SOTV | exostoses (multiple) 2 | - | HPRD,BioGRID | 10639137|10679296 |
| FABP4 | A-FABP | aP2 | fatty acid binding protein 4, adipocyte | Affinity Capture-MS | BioGRID | 17353931 |
| GALNT5 | GALNAC-T5 | MGC165041 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) | - | HPRD,BioGRID | 10545594 |
| HNF4A | FLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14 | hepatocyte nuclear factor 4, alpha | Affinity Capture-MS | BioGRID | 17353931 |
| HYOU1 | DKFZp686N08236 | FLJ94899 | FLJ97572 | Grp170 | HSP12A | ORP150 | hypoxia up-regulated 1 | Affinity Capture-MS | BioGRID | 17353931 |
| RPS29 | - | ribosomal protein S29 | Affinity Capture-MS | BioGRID | 17353931 |
| SNCG | BCSG1 | SR | synuclein, gamma (breast cancer-specific protein 1) | Affinity Capture-MS | BioGRID | 17353931 |
| STK16 | FLJ39635 | KRCT | MPSK | PKL12 | TSF1 | serine/threonine kinase 16 | Affinity Capture-MS | BioGRID | 17353931 |
| TCEB1 | SIII | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) | Affinity Capture-MS | BioGRID | 17353931 |
| TRAP1 | HSP75 | HSP90L | TNF receptor-associated protein 1 | - | HPRD,BioGRID | 10545594 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE | 26 | 16 | All SZGR 2.0 genes in this pathway |
| REACTOME HS GAG BIOSYNTHESIS | 31 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | 52 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME GLYCOSAMINOGLYCAN METABOLISM | 111 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF CARBOHYDRATES | 247 | 154 | All SZGR 2.0 genes in this pathway |
| BARRIER COLON CANCER RECURRENCE UP | 42 | 28 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| DARWICHE SKIN TUMOR PROMOTER UP | 142 | 96 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK LOW UP | 162 | 104 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK HIGH UP | 147 | 101 | All SZGR 2.0 genes in this pathway |
| DARWICHE SQUAMOUS CELL CARCINOMA UP | 146 | 104 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| KANNAN TP53 TARGETS UP | 58 | 40 | All SZGR 2.0 genes in this pathway |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL LONG TERM | 302 | 191 | All SZGR 2.0 genes in this pathway |
| GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |
| LINSLEY MIR16 TARGETS | 206 | 127 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |