Gene Page:ABCD1

Summary?
GeneID 215
Symbol ABCD1
Synonyms ABC42|ALD|ALDP|AMN
Description ATP binding cassette subfamily D member 1
Reference MIM:300371|HGNC:HGNC:61|Ensembl:ENSG00000101986|HPRD:02300|Vega:OTTHUMG00000024215
Gene type protein-coding
Map location Xq28
Fetal beta 0.121
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10994209 chr10 61877705 ABCD1 215 0.07 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FOLR1 0.61 0.26
CP 0.59 0.33
C2orf40 0.58 0.34
KCNJ13 0.57 0.21
CLIC6 0.56 0.31
TTR 0.56 0.09
CLDN3 0.55 0.29
ABCA4 0.54 0.17
RBM47 0.53 0.21
TYRP1 0.53 0.45
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DACT1 -0.21 0.01
KLHL1 -0.21 -0.01
SSBP2 -0.20 -0.01
PCSK9 -0.20 -0.09
SCUBE1 -0.20 -0.20
SRGAP1 -0.20 -0.07
CBLB -0.20 -0.01
SEMA3A -0.20 -0.02
SLA -0.20 0.03
SH3BP2 -0.19 -0.21

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ABC TRANSPORTERS 44 29 All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 78 47 All SZGR 2.0 genes in this pathway
REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 18 11 All SZGR 2.0 genes in this pathway
REACTOME ALPHA LINOLENIC ACID ALA METABOLISM 12 6 All SZGR 2.0 genes in this pathway
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 34 21 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME PEROXISOMAL LIPID METABOLISM 21 11 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 126 86 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162 116 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP 108 69 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 DN 66 38 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS IMPRINTED AND X LINKED 17 8 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL DN 45 30 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
SU PANCREAS 54 30 All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN 50 36 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway