SZGR2 - Beplay体育中心

Summary？

基因	2175
象征	Fanca
Synonyms	FA \| FA-H \| FA1 \| FAA \| FACA \| FAH \| FANCH
Description	Fanconi贫血补充小组A
Reference	MIM:607139\|HGNC:HGNC:3582\|ENSEMBL：ENSG00000187741\|HPRD:06186\|Vega:OTTHUMG00000173049
基因类型	蛋白质编码
Map location	16q24.3
Pascal p-value	3.312E-5
Sherlock p-value	0.81
主持人	Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS4141780	CHR20	40297792	Fanca	2175		0.19		反式

第二节。转录组注释

一般基因表达（GTEX）

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
AKT1	akt \|MGC99656 \|PKB \|pkb-alpha \|Prkba \|RAC \|Rac-Alpha	V-Akt鼠胸腺瘤病毒癌基因同源1	Two-hybrid	Biogrid	14499622
ALDOA	ALDA \| MGC10942 \| MGC17716 \| MGC17767	aldolase A, fructose-bisphosphate	Two-hybrid	Biogrid	14499622
ATP5B	ATPMB \|atpsb \|MGC5231	ATP合酶，H+转运，线粒体F1复合物，β多肽	Two-hybrid	Biogrid	14499622
AZIN1	MGC3832 \|MGC691 \|oazi \|Oazin \|ODC1L	抗酶抑制剂1	Two-hybrid	Biogrid	14499622
BAT1	D6S81E \|ddx39b \|UAP56	HLA-B associated transcript 1	Two-hybrid	Biogrid	14499622
BLM	BS \|MGC126616 \|MGC131618 \|MGC131620 \|recq2 \|recql2 \|RECQL3	布卢姆综合症	Affinity Capture-MS	Biogrid	12973351
BRCA1	Brcai \|BRCC1 \|虹膜\|PSCP \|RNF53	breast cancer 1, early onset	BRCA1与Fanca互动。	绑定	12354784
BRCA1	Brcai \|BRCC1 \|虹膜\|PSCP \|RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	12354784
CCT3	CCT-gamma \| CCTG \| PIG48 \| TCP-1-gamma \| TRIC5	伴侣蛋白含有TCP1，亚基3（伽马）	Two-hybrid	Biogrid	14499622
CD52	CDW52	CD52 molecule	in vivo	Biogrid	6186
CD79A	Iga \|MB-1	CD79A分子，免疫球蛋白相关α	Two-hybrid	Biogrid	14499622
CDC2	cdc28a \|CDK1 \|DKFZP686L20222 \|MGC111195	cell division cycle 2, G1 to S and G2 to M	Affinity Capture-MS	Biogrid	15082718
楚克	ikbka \|ikk-alpha \|ikk1 \|ikka \|nfkbika \|TCF16	保守的螺旋环螺旋无处不在激酶	亲和力捕获 - 韦斯特恩 Two-hybrid	Biogrid	12210728\|14499622
daxx	Bing2 \|DAP6 \|EAP1 \|MGC126245 \|MGC126246	death-domain associated protein	Two-hybrid	Biogrid	14499622
DNAJB1	HSPF1 \|HDJ1 \|HSP40 \|SIS1	DNAJ（HSP40）同源物，亚家族B，成员1	Two-hybrid	Biogrid	14499622
dus4l	DUS4 \| MGC133233 \| PP35	二氢丙啶合酶4样（S. cerevisiae）	Two-hybrid	Biogrid	14499622
ENO1	eno1l1 \|MBP-1 \|MPB1 \|nne \|pph	enolase 1, (alpha)	Two-hybrid	Biogrid	14499622
ERCC4	RAD1 \| XPF	excision repair cross-complementing rodent repair deficiency, complementation group 4	亲和力捕获 - 韦斯特恩	Biogrid	12571280
Fanca	fa \|FA-H \|FA1 \|FAA \|FACA \|法\|Fanch \|MGC75158	Fanconi贫血，互补小组A	Affinity Capture-MS 亲和力捕获 - 韦斯特恩 Two-hybrid	Biogrid	9742112\|10652215 \|11157805\|12973351
Fanca	fa \|FA-H \|FA1 \|FAA \|FACA \|法\|Fanch \|MGC75158	Fanconi贫血，互补小组A	Fancainteracts with FANCA.	绑定	15138265
联邦	FA3 \| FAC \| FACC \| FLJ14675	Fanconi贫血，互补组C	Affinity Capture-MS 亲和力捕获 - 韦斯特恩重构的复合物 Two-hybrid	Biogrid	10373536\|10551855 \|10627486\|10961856 \|11063725\|12210728 \|12239156\|12973351 \|15082718
联邦	FA3 \| FAC \| FACC \| FLJ14675	Fanconi贫血，互补组C	-	HPRD	9742112
狂欢	脸\|fae	Fanconi贫血，互补小组E	-	HPRD	11157805\|12239156
狂欢	脸\|fae	Fanconi贫血，互补小组E	Affinity Capture-MS 亲和力捕获 - 韦斯特恩重构的复合物 Two-hybrid	Biogrid	11157805\|12093742 \|12239156\|12973351
旗	faf \|MGC126856	Fanconi贫血，互补小组F	-	HPRD,BioGRID	11063725
粉丝	FAG \| XRCC9	Fanconi贫血，互补小组G	Fanca与Fancg互动。	绑定	15138265
粉丝	FAG \| XRCC9	Fanconi贫血，互补小组G	-	HPRD	10468603\|11050007
粉丝	FAG \| XRCC9	Fanconi贫血，互补小组G	Affinity Capture-MS 亲和力捕获 - 韦斯特恩共纯化体外 in vivo 重构的复合物 Two-hybrid	Biogrid	10373536\|10468603 \|10468606\|10567393 \|10627486\|10652215 \|10961856\|11050007 \|11157805\|11739169 \|11918676\|12210728 \|12239156\|12649160 \|12973351\|14697762 \|15082718\|15138265 \|16189514
幻想	FAAP43 \|FLJ10335 \|PHF9 \|pog	Fanconi贫血，互补小组L	Affinity Capture-MS	Biogrid	12973351
GNB2	-	鸟嘌呤核苷酸结合蛋白（G蛋白），β多肽2	Two-hybrid	Biogrid	14499622
HPRT1	HGPRT \| HPRT	低黄嘌呤磷酸贝糖基转移酶1	Two-hybrid	Biogrid	14499622
HSP90AA1	FLJ31884 \|HSP86 \|HSP89A \|HSP90A \|HSP90N \|HSPC1 \|HSPCA \|HSPCAL1 \|HSPCAL4 \|HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	Two-hybrid	Biogrid	14499622
HSP90B1	ECGP \| GP96 \| GRP94 \| TRA1	热休克蛋白90KDAβ（GRP94），成员1	Affinity Capture-MS	Biogrid	15082718
ifit3	CIG-49 \| GARG-49 \| IFI60 \| IFIT4 \| IRG2 \| ISG60 \| RIG-G	干扰素诱导的四肽重复蛋白3	Two-hybrid	Biogrid	14499622
ikbkb	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	B细胞，激酶β的Kappa光多肽基因增强子的抑制剂	-	HPRD,BioGRID	12210728
KRT1	CK1 \|EHK1 \|K1 \|KRT1A	角蛋白1	Two-hybrid	Biogrid	14499622
lipg	EDL \| EL \| PRO719	脂肪酶，内皮	Two-hybrid	Biogrid	14499622
MKNK1	MNK1	MAP激酶相互作用丝氨酸/苏氨酸激酶1	Two-hybrid	Biogrid	14499622
MX1	ifi-78k \|ifi78 \|MX \|MXA	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	Two-hybrid	Biogrid	14499622
恩	1110035O14Rik \| DKFZp666B131 \| MGC117256 \| PBEF \| PBEF1 \| VF \| VISFATIN	nicotinamide phosphoribosyltransferase	Two-hybrid	Biogrid	14499622
NUB1	BS4 \|nub1l \|NYREN18	negative regulator of ubiquitin-like proteins 1	Two-hybrid	Biogrid	14499622
PRPF31	DKFZp566J153 \| NY-BR-99 \| PRP31 \| RP11	PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)	Two-hybrid	Biogrid	14499622
PSMA5	MGC117302 \| MGC125802 \| MGC125803 \| MGC125804 \| PSC5 \| ZETA	proteasome (prosome, macropain) subunit, alpha type, 5	Two-hybrid	Biogrid	14499622
RMI1	Blap75 \|C9orf76 \|FLJ12888 \|RP11-346I8.1	RMI1，RECQ介导的基因组不稳定性1，同源物（S. cerevisiae）	Affinity Capture-MS	Biogrid	12973351
RPA1	HSSB \|repa1 \|RF-A \|RP-A \|RPA70	复制蛋白A1，70KDA	Affinity Capture-MS	Biogrid	12973351
RPL18	-	核糖体蛋白L18	Two-hybrid	Biogrid	14499622
SGK1	SGK	血清/糖皮质激素调节激酶1	Two-hybrid	Biogrid	14499622
SMARCA4	BAF190 \|BRG1 \|FLJ39786 \|SNF2 \|snf2-beta \|snf2l4 \|SNF2LB \|swi2 \|HSNF2B	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	-	HPRD,BioGRID	11726552
SMARCC1	BAF155 \|cracc1 \|RSC8 \|srg3 \|SWI3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	-	HPRD	11726552
Smarcd3	BAF60C \|cracd3 \|MGC111010 \|RSC6P	SWI/SNF相关，矩阵相关，染色质的肌动蛋白依赖性调节剂，亚家族D，成员3	-	HPRD	11726552
SNX5	FLJ10931	排序Nexin 5	-	HPRD,BioGRID	10600472
SPTA1	EL2 \|SPTA	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	亲和力捕获 - 韦斯特恩	Biogrid	12571280
SPTAN1	（alpha）ii-spectrin \|FLJ44613 \|Neas	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	亲和力捕获 - 韦斯特恩共纯化	Biogrid	10551855\|11401546 \|12571280
TAF10	taf2a \|taf2h \|TAFII30	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa	Two-hybrid	Biogrid	14499622
tcerg1	CA150 \|MGC133200 \|taf2s	转录伸长调节器1	Two-hybrid	Biogrid	14499622
TCP1	CCT-alpha \| CCT1 \| CCTa \| D6S230E \| TCP-1-alpha	t-complex 1	Two-hybrid	Biogrid	14499622
top3A	top3	拓扑异构酶（DNA）III alpha	Affinity Capture-MS	Biogrid	12973351
TPT1	FLJ27337 \| HRF \| TCTP \| p02	肿瘤蛋白，翻译控制1	Two-hybrid	Biogrid	14499622
ZNF24	kox17 \|RSG-A \|Znf191 \|ZSCAN3 \|ZFP191	锌指蛋白24	Two-hybrid	Biogrid	14499622

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
PID FANCONI PATHWAY	47	28	All SZGR 2.0 genes in this pathway
PID BARD1 PATHWAY	29	19	All SZGR 2.0 genes in this pathway
Reactome Fanconi贫血途径	25	11	All SZGR 2.0 genes in this pathway
Reactome DNA修复	112	59	All SZGR 2.0 genes in this pathway
通过CD40 UP的Hollmann凋亡	201	125	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN	335	193	All SZGR 2.0 genes in this pathway
Mullighan NPM1签名3	341	197	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
下巴乳腺癌拷贝编号DN	16	10	All SZGR 2.0 genes in this pathway
GRAESSMANN凋亡的做XORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
Roylance乳腺癌16Q复制号码	63	44	All SZGR 2.0 genes in this pathway
Mathew Fanconi贫血基因	11	7	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲	479	299	All SZGR 2.0 genes in this pathway
Pujana乳腺癌点燃int网络	101	73	All SZGR 2.0 genes in this pathway
Pujana BRCA2 PCC网络	423	265	All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE UP	61	25	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN	637	377	All SZGR 2.0 genes in this pathway
洛佩兹MBD目标	957	597	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Benporath循环基因	648	385	All SZGR 2.0 genes in this pathway
Benporath增殖	147	80	All SZGR 2.0 genes in this pathway
Shin B细胞淋巴瘤簇2	30	23	All SZGR 2.0 genes in this pathway
Kauffmann DNA修复基因	230	137	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 16Q24 AMPLICON	53	38	All SZGR 2.0 genes in this pathway
尼古斯基在乳腺癌中突变并扩增	94	60	All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP	70	47	All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN	287	208	All SZGR 2.0 genes in this pathway
Bild E2F3致癌特征	246	153	All SZGR 2.0 genes in this pathway
由E2F4绑定的Marson未刺激	728	415	All SZGR 2.0 genes in this pathway
Sansom APC目标需要MYC	210	123	All SZGR 2.0 genes in this pathway
Smid乳腺癌基础	648	398	All SZGR 2.0 genes in this pathway
MATZUK MEIOTIC AND DNA REPAIR	39	26	All SZGR 2.0 genes in this pathway
MATZUK精子细胞	72	55	All SZGR 2.0 genes in this pathway
级结肠癌	871	505	All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应	342	220	All SZGR 2.0 genes in this pathway
格雷希克癌症复制号码	323	240	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP	139	95	All SZGR 2.0 genes in this pathway
Vantveer乳腺癌ESR1 DN	240	153	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN	185	116	All SZGR 2.0 genes in this pathway
张TLX目标60小时DN	277	166	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS DN	89	50	All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S3	266	180	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S	162	86	All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应24小时	324	193	All SZGR 2.0 genes in this pathway
Lee BMP2靶向DN	882	538	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN	148	88	All SZGR 2.0 genes in this pathway

Gene Page:Fanca