Gene Page:ACSL3

Summary?
GeneID 2181
Symbol ACSL3
Synonyms ACS3|FACL3|PRO2194
Description acyl-CoA synthetase long-chain family member 3
Reference MIM:602371|HGNC:HGNC:3570|HPRD:03845|
Gene type protein-coding
Map location 2q34-q35
Pascal p-value 0.979
Fetal beta -0.886
eGene Caudate basal ganglia
Myers' cis & trans
Support CELL METABOLISM
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00916
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01016

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9882137 chr3 29494146 ACSL3 2181 0.04 trans
rs4491879 chr3 189373908 ACSL3 2181 0.07 trans
rs4505678 chr3 189374356 ACSL3 2181 0.07 trans
rs17139868 chr7 117079228 ACSL3 2181 0.04 trans
rs1999514 chr13 84147878 ACSL3 2181 0.12 trans
rs17196823 chr18 67270658 ACSL3 2181 0.13 trans
rs12327665 chr19 39622639 ACSL3 2181 0.11 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
P2RY1 0.79 0.23
FAM40B 0.77 0.23
CCDC88C 0.75 0.67
SECTM1 0.75 0.06
C13orf29 0.74 0.37
FOXO1 0.74 0.36
RXRG 0.74 0.07
SMOC2 0.73 0.08
PTPRQ 0.72 0.18
LAMC2 0.71 0.55
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CHPT1 -0.19 -0.34
COX4I2 -0.18 -0.47
CDADC1 -0.17 0.06
MYL3 -0.17 -0.52
BAALC -0.17 -0.28
LGALS3 -0.17 -0.50
SLC25A33 -0.17 -0.46
HIGD1B -0.16 -0.48
S100A4 -0.16 -0.43
MUSTN1 -0.16 -0.39

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000287 magnesium ion binding IEA -
GO:0005515 protein binding 新闻学会 17220478
GO:0004321 fatty-acyl-CoA synthase activity TAS 8663269
GO:0004467 long-chain-fatty-acid-CoA ligase activity IEA -
GO:0016874 ligase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008152 metabolic process IEA -
GO:0006631 fatty acid metabolic process IEA -
GO:0006629 lipid metabolic process IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005792 microsome IEA -
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005739 mitochondrion IEA -
GO:0005741 mitochondrial outer membrane IEA -
GO:0005777 peroxisome IEA -
GO:0005778 peroxisomal membrane IEA -
GO:0005783 endoplasmic reticulum IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG FATTY ACID METABOLISM 42 29 All SZGR 2.0 genes in this pathway
KEGG PPAR SIGNALING PATHWAY 69 47 All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 78 47 All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 67 57 All SZGR 2.0 genes in this pathway
REACTOME TRIGLYCERIDE BIOSYNTHESIS 38 26 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACYL COA BIOSYNTHESIS 18 15 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168 115 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 14 12 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169 118 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
CASORELLI急性早幼粒细胞白血病DN 663 425 All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO ANDROGEN UP 29 21 All SZGR 2.0 genes in this pathway
王FORSKOLIN反应 23 17 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352 225 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 135 82 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC UP 21 16 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A UP 77 49 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 86 61 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
ASTIER INTEGRIN SIGNALING 59 44 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP 131 87 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261 183 All SZGR 2.0 genes in this pathway
GEISS RESPONSE TO DSRNA UP 38 29 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR DN 101 64 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
KONDO COLON CANCER HCP WITH H3K27ME1 26 13 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250 168 All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE DN 69 44 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198 128 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 122 84 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245 150 All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209 137 All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 138 99 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 76 51 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157 106 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND WITH H4K20ME1 MARK 145 82 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227 151 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-223 136 143 1A,m8 海关a-miR-223 UGUCAGUUUGUCAAAUACCCC
miR-26 54 61 1A,m8 海关a-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
海关a-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-375 487 493 1A 海关a-miR-375 UUUGUUCGUUCGGCUCGCGUGA
miR-381 519 525 m8 海关a-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-384 372 378 1A 海关a-miR-384 AUUCCUAGAAAUUGUUCAUA
miR-505 483 489 1A 海关a-miR-505 GUCAACACUUGCUGGUUUCCUC