基因Page:ACSL4

Summary?
基因ID 2182
Symbol ACSL4
Synonyms ACS4|FACL4|LACS4|MRX63|MRX68
Description acyl-CoA synthetase long-chain family member 4
Reference MIM:300157|HGNC:HGNC:3571|Ensembl:ENSG00000068366|HPRD:02152|Vega:OTTHUMG00000022190
基因type protein-coding
Map location Xq22.3-q23
Sherlock p-value 0.463
TADA p-value 0.011
Fetal beta -1.003
Support CompositeSet
Potential synaptic genes

基因in Data Sources
基因set name Method of gene set Description Info
CV:PGCnp 全基因组关联研究 GWAS
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

基因 Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
ACSL4 chrX 108904872 G A NM_004458
NM_004458
NM_022977
NM_022977		 .
p.529R>C
.
p.570R>C		 splice
missense
splice
missense		 Schizophrenia DNM:Fromer_2014


Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

基因expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
RPS9 0.96 0.96
RPS10 0.95 0.95
RPS14 0.95 0.94
RPL36 0.95 0.95
RPS29 0.94 0.92
RPS15P5 0.94 0.94
RPL8 0.94 0.94
RPL32 0.94 0.93
RPS23 0.94 0.90
RPL18 0.94 0.94
Top 10 negatively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
SYNM -0.61 -0.75
EPB41L2 -0.60 -0.74
MAP3K5 -0.57 -0.68
APOL1 -0.57 -0.72
PTPRB -0.56 -0.68
PK4P -0.56 -0.67
COBLL1 -0.56 -0.68
ABCB1 -0.56 -0.68
BCL2L2 -0.55 -0.66
MAP7 -0.55 -0.78

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000287 magnesium ion binding IEA -
GO:0004467 long-chain-fatty-acid-CoA ligase activity TAS 9480748
GO:0016874 ligase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008152 metabolic process IEA -
GO:0007611 learning or memory TAS 9480748
GO:0006631 fatty acid metabolic process IEA -
GO:0006629 lipid metabolic process NAS 9598324
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005792 microsome IEA -
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005737 cytoplasm IDA 18029348
GO:0005739 mitochondrion IEA -
GO:0005741 mitochondrial outer membrane IEA -
GO:0005777 peroxisome IEA -
GO:0005778 peroxisomal membrane IEA -
GO:0005783 endoplasmic reticulum IEA -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane IDA 18029348

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG FATTY ACID METABOLISM 42 29 All SZGR 2.0 genes in this pathway
KEGG PPAR SIGNALING PATHWAY 69 47 All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 78 47 All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 67 57 All SZGR 2.0 genes in this pathway
REACTOME TRIGLYCERIDE BIOSYNTHESIS 38 26 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACYL COA BIOSYNTHESIS 18 15 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168 115 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 14 12 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
LANDIS BREAST CANCER PROGRESSION UP 44 27 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN 141 84 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215 137 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST PRENEOPLASTIC UP 20 10 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 150 93 All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION DN 100 64 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE 105 68 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2 153 102 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156 106 All SZGR 2.0 genes in this pathway
WEI MIR34A TARGETS 148 97 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION 40 29 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP 88 64 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 174 96 All SZGR 2.0 genes in this pathway
MATZUK IMPLANTATION AND UTERINE 22 15 All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN 108 64 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 108 68 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP 153 107 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170 105 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS INTERFERON UP 26 10 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 76 51 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL 129 85 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
李BMP2目标UP 745 475 All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL UP 105 46 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 1355 1361 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-129-5p 1366 1373 1A,m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-130/301 1392 1398 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-132/212 1381 1387 1A hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG
miR-133 2010 2016 m8 hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
miR-142-3p 425 431 m8 hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
miR-144 1355 1361 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-145 1204 1211 1A,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152 895 901 1A hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/497 1973 1980 1A,m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d 1394 1400 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-186 1387 1393 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-19 2652 2658 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-224 2092 2098 m8 hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-34/449 1913 1920 1A,m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-450 1366 1372 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
miR-496 2065 2071 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-503 1974 1980 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG
miR-543 1538 1544 1A hsa-miR-543 AAACAUUCGCGGUGCACUUCU
miR-7 373 379 m8 hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG