SZGR2 - Beplay体育中心

概括?

基因	219541
象征	MED19
Synonyms	DT2P1G7 \| LCMR1 \| MED19AS
Description	mediator complex subunit 19
参考	MIM:612385\|HGNC:HGNC:29600\|Ensembl:ENSG00000156603\|HPRD:17477\|Vega：Otthumg00000167199
Gene type	protein-coding
Map location	11q12.1
Pascal p-value	3.987E-7
Sherlock P值	0.196
Fetal beta	0.499
DMG	1（＃研究）

数据源中的基因

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	作者研究了来自18例第一期精神分裂症（FESZ）和15个正常对照的18例外周血细胞中DNA的甲基化谱。	1
Network	人蛋白蛋白质相互作用网络中核心基因的最短路径距离	Contribution to shortest path in PPI network: 0.034

第一节遗传学和表观遗传学注释

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	学习
cg27497687	11	57479637	MED19		-0.026	0.25	DMG:Nishioka_2013

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因

Section III. Gene Ontology annotation

分子功能	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	蛋白质结合	IEA		-
生物过程	GO term	Evidence	Neuro keywords	PubMed ID
去：0006355	regulation of transcription, DNA-dependent	IEA		-
去：0006350	transcription	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
去：0000119	mediator complex	IEA		-
GO:0005634	核	IEA		-

第四节。蛋白质蛋白相互作用注释

互动者	Aliases B	Official full name B	Experimental	资源	PubMed ID
CCNC	cycc	cyclin C	亲和力捕获ms	BioGRID	15175163
cdc2l6	CDK11 \| KIAA1028 \| bA346C16.3	cell division cycle 2-like 6 (CDK8-like)	亲和力捕获ms	BioGRID	15175163
CDK8	K35 \| MGC126074 \| MGC126075	cyclin-dependent kinase 8	亲和力捕获ms	BioGRID	15175163
DCK	MGC117410 \| MGC138632	deoxycytidine kinase	两个杂交	BioGRID	16169070
MED1	CRSP1 \|CRSP200 \|滴水205 \|滴水230 \|MGC71488 \|PBP \|PPARBP \|PPARGBP \|RB18A \|TRAP220 \| TRIP2	mediator complex subunit 1	亲和力捕获ms Affinity Capture-Western	BioGRID	14638676\|15175163
MED10	L6 \|MGC5309 \|nut2 \|TRG20	mediator complex subunit 10	亲和力捕获ms Affinity Capture-Western	BioGRID	12584197\|14638676 \|15175163
MED11	HSPC296 \| MGC88387	mediator complex subunit 11	亲和力捕获ms Affinity Capture-Western	BioGRID	14576168\|14638676 \|15175163
MED12	CAGH45 \|霍普\|KIAA0192 \|OPA1 \|TNRC11 \|陷阱230	mediator complex subunit 12	亲和力捕获ms	BioGRID	15175163
MED13	ARC250 \|滴水250 \|HSPC221 \|KIAA0593 \|thrap1 \|陷阱240	mediator complex subunit 13	亲和力捕获ms	BioGRID	15175163
MED13L	DKFZp781D0112 \| FLJ21627 \| KIAA1025 \| PROSIT240 \| THRAP2 \| TRAP240L	mediator complex subunit 13-like	亲和力捕获ms	BioGRID	15175163
MED14	CRSP150 \|CRSP2 \|CSRP \|CXORF4 \|滴150 \|exlm1 \|MGC104513 \|RGR1 \|陷阱170	mediator complex subunit 14	亲和力捕获ms	BioGRID	15175163
MED15	ARC105 \| CAG7A \| CTG7A \| DKFZp686A2214 \| DKFZp762B1216 \| FLJ42282 \| FLJ42935 \| PCQAP \| TIG-1 \| TIG1 \| TNRC7	mediator complex subunit 15	亲和力捕获ms	BioGRID	15175163
MED16	DRIP92 \| THRAP5 \| TRAP95	mediator complex subunit 16	亲和力捕获ms	BioGRID	15175163
MED17	CRSP6 \| CRSP77 \| DRIP80 \| FLJ10812 \| TRAP80	mediator complex subunit 17	亲和力捕获ms Affinity Capture-Western Reconstituted Complex	BioGRID	12584197\|14576168 \|14638676\|15175163
MED17	CRSP6 \| CRSP77 \| DRIP80 \| FLJ10812 \| TRAP80	mediator complex subunit 17	TRAP80 interacts with LCMR1. This interaction was modelled on a demonstrated interaction between human TRAP80 and mouse LCMR1.	BIND	12584197
MED18	FLJ20045 \| p28b	mediator complex subunit 18	亲和力捕获ms Affinity Capture-Western	BioGRID	14576168\|14638676 \|15175163
MED19	DT2P1G7 \| LCMR1	mediator complex subunit 19	亲和力捕获ms Affinity Capture-Western	BioGRID	14638676\|15175163
MED20	DKFZp586D2223 \| MGC29869 \| PRO0213 \| TRFP	mediator complex subunit 20	亲和力捕获ms Affinity Capture-Western	BioGRID	14576168\|15175163
MED21	SRB7 \| SURB7	中介复合体亚基21	亲和力捕获ms	BioGRID	15175163
MED22	MED24 \| MGC48682 \| SURF5	中介复合体亚基22	亲和力捕获ms	BioGRID	15175163
MED23	CRSP130 \| CRSP133 \| CRSP3 \| DKFZp434H0117 \| DRIP130 \| SUR2	中介复合体亚基23	亲和力捕获ms	BioGRID	15175163
MED24	ARC100 \| CRSP100 \| CRSP4 \| DRIP100 \| KIAA0130 \| MGC8748 \| THRAP4 \| TRAP100	介体复合体亚基24	亲和力捕获ms	BioGRID	15175163
MED25	酸1 \|Arc92 \|DKFZP434K0512 \|MGC70671 \|P78 \|PTOV2 \|TCBAP0758	mediator complex subunit 25	亲和力捕获ms Affinity Capture-Western	BioGRID	14638676\|15175163
MED26	CRSP7 \| CRSP70	mediator complex subunit 26	亲和力捕获ms	BioGRID	15175163
MED27	CRAP34 \| CRSP34 \| CRSP8 \| MGC11274 \| TRAP37	中介复合体亚基27	TRAP37与LCMR1相互作用。这种相互作用是建立在人类TRAP37和小鼠LCMR1之间的相互作用上的模型。	BIND	12584197
MED27	CRAP34 \| CRSP34 \| CRSP8 \| MGC11274 \| TRAP37	中介复合体亚基27	亲和力捕获ms Reconstituted Complex	BioGRID	12584197\|15175163
MED28	1500003d12rik \|DKFZP434N185 \|EG1 \|魔术	中介复合体亚基28	-	HPRD,BioGRID	15175163
MED29	DKFZp434H247 \| IXL	中介复合体亚基29	-	HPRD,BioGRID	14576168
MED30	MGC9890 \| THRAP6 \| TRAP25	中介复合体亚基30	亲和力捕获ms	BioGRID	15175163
MED31	3110004H13rik \|CGI-125 \|FLJ27436 \|FLJ36714 \|SOH1	中介复合体亚基31	-	HPRD,BioGRID	12584197
MED4	DRIP36 \| FLJ10956 \| HSPC126 \| RP11-90M2.2 \| TRAP36 \| VDRIP	mediator complex subunit 4	亲和力捕获ms Affinity Capture-Western	BioGRID	14638676\|15175163
MED6	NY-REN-28	mediator complex subunit 6	亲和力捕获ms Affinity Capture-Western	BioGRID	14576168\|15175163
MED7	CRSP33 \| CRSP9 \| MGC12284	mediator complex subunit 7	亲和力捕获ms	BioGRID	15175163
MED8	ARC32 \| MGC17544 \| MGC19641	mediator complex subunit 8	亲和力捕获ms Affinity Capture-Western	BioGRID	14576168\|14638676 \|15175163
MED9	FLJ10193 \|Med25 \|MGC138234	mediator complex subunit 9	亲和力捕获ms	BioGRID	15175163
MED9	FLJ10193 \|Med25 \|MGC138234	mediator complex subunit 9	-	HPRD	14638676
NFKBIA	ikba \|Mad-3 \|nfkbi	B细胞抑制剂Alpha中Kappa光多肽基因增强子的核因子	两个杂交	BioGRID	16169070
polr2a	MGC75453 \|polr2 \|波拉\|RPB1 \|RPBH1 \|RPO2 \|rpol2 \|rpiils \|HRPB220 \|HSRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	亲和力捕获ms	BioGRID	15175163
polr2b	pol2rb \|RPB2 \|HRPB140 \|HSRPB2	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	亲和力捕获ms	BioGRID	15175163
polr2c	RPB3 \|RPB31 \|HRPB33 \|HSRPB3	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	亲和力捕获ms	BioGRID	15175163
polr2d	HSRBP4 \|HSRPB4 \|RBP4	polymerase (RNA) II (DNA directed) polypeptide D	亲和力捕获ms	BioGRID	15175163
polr2e	RPABC1 \|RPB5 \|xap4 \|HRPB25 \|HSRPB5	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	亲和力捕获ms	BioGRID	15175163
polr2f	HRBP14.4 \|polrf \|RPABC2 \|RPB14.4 \|RPB6	polymerase (RNA) II (DNA directed) polypeptide F	亲和力捕获ms	BioGRID	15175163
polr2g	MGC138367 \|MGC138369 \|RPB7 \|HRPB19 \|HSRPB7	polymerase (RNA) II (DNA directed) polypeptide G	亲和力捕获ms	BioGRID	15175163
polr2h	RPABC3 \|RPB17 \|RPB8 \|HSRPB8	polymerase (RNA) II (DNA directed) polypeptide H	亲和力捕获ms	BioGRID	15175163
polr2i	RPB9 \| hRPB14.5	polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa	亲和力捕获ms	BioGRID	15175163
polr2j	MGC71910 \| POLR2J1 \| RPB11 \| RPB11A \| RPB11m \| hRPB14	polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa	亲和力捕获ms	BioGRID	15175163
polr2l	RBP10 \| RPABC5 \| RPB10 \| RPB10beta \| RPB7.6 \| hRPB7.6 \| hsRPB10b	DNA聚合酶(RNA) II(导演)多肽L,7.6kDa	亲和力捕获ms	BioGRID	15175163
radil	FLJ10324 \|KIAA1849 \|MGC161589	Rap GTPase interactor	两个杂交	BioGRID	16169070
TFF1	BCEI \| D21S21 \| HP1.A \| HPS2 \| pNR-2 \| pS2	trefoil factor 1	MED19 interacts with pS2 promoter.	BIND	15989967

V.途径注释

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME DEVELOPMENTAL BIOLOGY	396	292	该途径中的所有SZGR 2.0基因
Reactome Ppara激活基因表达	104	72	该途径中的所有SZGR 2.0基因
脂质和脂蛋白的反应组代谢	478	302	该途径中的所有SZGR 2.0基因
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	该途径中的所有SZGR 2.0基因
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	该途径中的所有SZGR 2.0基因
奥斯曼膀胱癌	404	246	该途径中的所有SZGR 2.0基因
SHETH LIVER CANCER VS TXNIP LOSS PAM6	46	32	该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 3 DN	918	550	该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

mirna家族	Target position			mirna id	miRNA seq
mirna家族	UTR start	UTR end	匹配方法	mirna id	miRNA seq
miR-214	633	640	1A,m8	HSA-MIR-214^脑	ACAGCAGGCACAGACAGGCAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click这里查看与SZ相关的miRNA列表。
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击这里to see the list of brain related miRNAs.

Gene Page:MED19