Gene Page:FCGR3B
Summary?
| GeneID | 2215 |
| Symbol | FCGR3B |
| Synonyms | CD16|CD16b|FCG3|FCGR3|FCR-10|FCRIII|FCRIIIb |
| Description | Fc fragment of IgG receptor IIIb |
| Reference | MIM:610665|HGNC:HGNC:3620|Ensembl:ENSG00000162747|HPRD:09951|Vega:OTTHUMG00000074099 |
| Gene type | protein-coding |
| Map location | 1q23 |
| eGene | 元 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.00814 |
Section I. Genetics and epigenetics annotation
DNM table
DNM table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FCGR3B | chr1 | 161594360 | A | G | NM_000570 NM_001244753 NM_001271035 NM_001271036 NM_001271037 |
p.216V>A p.252V>A p.251V>A p.199V>A p.113V>A |
missense missense missense missense missense |
Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception我们eks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RCN2 | 0.78 | 0.78 |
| PAIP2 | 0.74 | 0.73 |
| GFM2 | 0.72 | 0.68 |
| MRPL19 | 0.72 | 0.70 |
| RAB4A | 0.72 | 0.70 |
| DNAJB9 | 0.72 | 0.73 |
| SRPRB | 0.72 | 0.66 |
| DNAJA3 | 0.71 | 0.69 |
| PTPLAD1 | 0.71 | 0.69 |
| SLC25A3 | 0.71 | 0.66 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.18 | -0.52 | -0.31 |
| AF347015.21 | -0.47 | -0.24 |
| AC010300.1 | -0.47 | -0.41 |
| AC100783.1 | -0.45 | -0.40 |
| AF347015.8 | -0.45 | -0.30 |
| AC098691.2 | -0.45 | -0.31 |
| AF347015.2 | -0.44 | -0.27 |
| AF347015.26 | -0.43 | -0.27 |
| MT-CO2 | -0.42 | -0.27 |
| MT-ATP8 | -0.42 | -0.27 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0019864 | IgG binding | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006955 | immune response | TAS | 2139735 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0031225 | anchored to membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY | 137 | 92 | All SZGR 2.0 genes in this pathway |
| KEGG LEISHMANIA INFECTION | 72 | 56 | All SZGR 2.0 genes in this pathway |
| KEGG SYSTEMIC LUPUS ERYTHEMATOSUS | 140 | 100 | All SZGR 2.0 genes in this pathway |
| SCHUETZ BREAST CANCER DUCTAL INVASIVE UP | 351 | 230 | All SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA UP | 294 | 178 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN | 463 | 290 | All SZGR 2.0 genes in this pathway |
| JAATINEN HEMATOPOIETIC STEM CELL DN | 226 | 132 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| FERRANDO TAL1 NEIGHBORS | 21 | 15 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| VERHAAK AML WITH NPM1 MUTATED UP | 183 | 111 | All SZGR 2.0 genes in this pathway |
| MCLACHLAN DENTAL CARIES DN | 245 | 144 | All SZGR 2.0 genes in this pathway |
| MCLACHLAN DENTAL CARIES UP | 253 | 147 | All SZGR 2.0 genes in this pathway |
| MARTINELLI IMMATURE NEUTROPHIL DN | 13 | 9 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER UP | 288 | 168 | All SZGR 2.0 genes in this pathway |