Gene Page:ALDH9A1

Summary?
GeneID 223
Symbol ALDH9A1
Synonyms ALDH4|ALDH7|ALDH9|E3|TMABADH
Description aldehyde dehydrogenase 9 family member A1
Reference MIM:602733|HGNC:HGNC:412|Ensembl:ENSG00000143149|HPRD:04109|Vega:OTTHUMG00000034677
Gene type protein-coding
Map location 1q23.1
Sherlock p-value 0.029
Fetal beta -0.218
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08343943 1 165668116 ALDH9A1 -0.028 0.91 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17276327 chr4 12326149 ALDH9A1 223 0.13 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TUBA1 0.93 0.85
RHBDD2 0.92 0.91
TUBG2 0.91 0.86
CTSD 0.91 0.93
COPS7A 0.91 0.90
THY1 0.91 0.88
GOT1 0.90 0.87
BSCL2 0.89 0.88
ABHD12 0.89 0.89
SNRPN 0.89 0.91
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RBMX2 -0.59 -0.66
KIAA1949 -0.59 -0.48
ZNF311 -0.57 -0.46
ZNF300 -0.57 -0.39
TUBB2B -0.56 -0.52
THOC2 -0.56 -0.57
SH3BP2 -0.56 -0.58
FNBP1L -0.56 -0.37
UPF3A -0.55 -0.58
ZNF551 -0.55 -0.41

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004029 aldehyde dehydrogenase (NAD) activity IDA 2925663
GO:0016491 oxidoreductase activity IEA -
GO:0019145 aminobutyraldehyde dehydrogenase activity IDA 2925663|8645224
GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0042136 neurotransmitter biosynthetic process IDA neuron, axon, Synap, Neurotransmitter (GO term level: 9) 2925663
GO:0006081 cellular aldehyde metabolic process IDA 8645224
GO:0009437 carnitine metabolic process IEA -
GO:0042445 hormone metabolic process TAS 2925663
GO:0055114 oxidation reduction IDA 2925663
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005829 cytosol IEA -
GO:0005856 cytoskeleton IDA 18029348
GO:0005634 nucleus IDA 18029348
GO:0005737 cytoplasm TAS 2925663

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCOLYSIS GLUCONEOGENESIS 62 41 All SZGR 2.0 genes in this pathway
KEGG ASCORBATE AND ALDARATE METABOLISM 25 17 All SZGR 2.0 genes in this pathway
KEGG FATTY ACID METABOLISM 42 29 All SZGR 2.0 genes in this pathway
KEGG VALINE LEUCINE AND ISOLEUCINE DEGRADATION 44 26 All SZGR 2.0 genes in this pathway
KEGG LYSINE DEGRADATION 44 29 All SZGR 2.0 genes in this pathway
KEGG ARGININE AND PROLINE METABOLISM 54 39 All SZGR 2.0 genes in this pathway
KEGG HISTIDINE METABOLISM 29 19 All SZGR 2.0 genes in this pathway
KEGG TRYPTOPHAN METABOLISM 40 33 All SZGR 2.0 genes in this pathway
KEGG BETA ALANINE METABOLISM 22 16 All SZGR 2.0 genes in this pathway
KEGG GLYCEROLIPID METABOLISM 49 26 All SZGR 2.0 genes in this pathway
KEGG PYRUVATE METABOLISM 40 26 All SZGR 2.0 genes in this pathway
KEGG PROPANOATE METABOLISM 33 22 All SZGR 2.0 genes in this pathway
KEGG BUTANOATE新陈代谢 34 20 All SZGR 2.0 genes in this pathway
KEGG LIMONENE AND PINENE DEGRADATION 10 8 All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 63 52 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN 25 13 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261 153 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176 115 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
BYSTRYKH造血年代TEM CELL QTL CIS 128 77 All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS 75 51 All SZGR 2.0 genes in this pathway
BYSTRYKH造血年代TEM CELL AND BRAIN QTL CIS 65 38 All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN 41 28 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C8 72 56 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN 123 76 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 88 65 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS DN 51 29 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN 113 76 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
DANG MYC TARGETS DN 31 25 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181 101 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 36HR 29 23 All SZGR 2.0 genes in this pathway
若林史江脂肪生成PPARG 8 d 658 397 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124/506 181 187 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC