Gene Page:FDXR

Summary?
GeneID 2232
Symbol FDXR
Synonyms ADXR
Description ferredoxin reductase
Reference MIM:103270|HGNC:HGNC:3642|Ensembl:ENSG00000161513|HPRD:00060|Vega:OTTHUMG00000179026
Gene type protein-coding
Map location 17q25.1
Pascal p-value 0.908
Sherlock p-value 0.308
Fetal beta -0.436
DMG 1 (# studies)
eGene Cortex
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25268537 17 72860402 FDXR 2.44E-5 0.257 0.017 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 FDXR 2232 1.13E-8 trans
rs3845734 chr2 171125572 FDXR 2232 4.286E-4 trans
rs7584986 chr2 184111432 FDXR 2232 0.01 trans
rs17762315 chr5 76807576 FDXR 2232 0.11 trans
rs16890367 chr6 38078448 FDXR 2232 0.17 trans
rs1929780 chr6 40757438 FDXR 2232 0.19 trans
rs16955618 chr15 29937543 FDXR 2232 1.89E-14 trans
rs1041786 chr21 22617710 FDXR 2232 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SLC4A4 0.82 0.79
CYBRD1 0.82 0.75
PDLIM5 0.81 0.77
KAT2B 0.79 0.74
ADD3 0.79 0.75
SLC7A11 0.79 0.74
GJA1 0.78 0.74
SUCLG2 0.78 0.76
ACSS3 0.78 0.79
GLUD1 0.77 0.71
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NR2C2AP -0.38 -0.44
ACTL6B -0.37 -0.40
AC011491.1 -0.37 -0.45
MED19 -0.37 -0.41
DPF1 -0.36 -0.35
PARP6 -0.36 -0.37
RAB33A -0.36 -0.41
C3orf54 -0.35 -0.39
DUSP12 -0.35 -0.38
BZW2 -0.35 -0.39

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID P53 DOWNSTREAM PATHWAY 137 94 All SZGR 2.0 genes in this pathway
PID TAP63 PATHWAY 54 40 All SZGR 2.0 genes in this pathway
RODRIGUES DCC TARGETS DN 121 84 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293 179 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID UP 45 26 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS AND ESOPHAGUS CANCER DN 37 22 All SZGR 2.0 genes in this pathway
KERLEY RESPONSE TO CISPLATIN UP 44 30 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
GALLUZZI PERMEABILIZE MITOCHONDRIA 43 31 All SZGR 2.0 genes in this pathway
SCHAVOLT TARGETS OF TP53 AND TP63 16 12 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN 73 47 All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE UP 27 19 All SZGR 2.0 genes in this pathway
CHUANG OXIDATIVE STRESS RESPONSE UP 28 18 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217 122 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447 277 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 91 59 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 90 58 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 116 74 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE MIDDLE 98 56 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 166 97 All SZGR 2.0 genes in this pathway
WARTERS RESPONSE TO IR SKIN 83 44 All SZGR 2.0 genes in this pathway
WARTERS IR RESPONSE 5GY 47 23 All SZGR 2.0 genes in this pathway