SZGR2 - Beplay体育中心

Summary？

基因	2246
象征	FGF1
Synonyms	AFGF\|ECGF\|ECGF-beta\|ECGFA\|ECGFB\|FGF-1\|FGF-alpha\|FGFA\|GLIO703\|HBGF-1\|HBGF1
Description	fibroblast growth factor 1
Reference	MIM：131220\|HGNC:HGNC:3665\|Ensembl:ENSG00000113578\|HPRD:00567\|Vega：Otthumg00000059703
基因类型	蛋白质编码
Map location	5Q31
Pascal p-value	0.216
胎儿β	-4.468
Support	神经营养蛋白信号传导

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
协会	A combined odds ratio method (Sun等。2008), association studies	1	Link to SZGene
GSMA_I	Genome scan meta-analysis	PSR：0.0032
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.00459
gsma_iie	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01718
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息

Section I. Genetics and epigenetics annotation

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC:分皮质区域;SM:森sory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	Pearson's Correlation	斯皮尔曼的相关性
LRIG1	0.81	0.80
ACSS1	0.79	0.91
INPPL1	0.77	0.78
ACACB	0.74	0.76
Ston2	0.74	0.76
AXL	0.74	0.87
Trip6	0.73	0.81
Notch3	0.73	0.63
RFX4	0.73	0.80
PBXIP1	0.72	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
ACTR10	-0.42	-0.49
C20orf7	-0.42	-0.56
RALYL	-0.42	-0.54
VPS29	-0.42	-0.52
NHEDC2	-0.42	-0.55
Med19	-0.42	-0.62
TAF9	-0.42	-0.57
HMGCLL1	-0.42	-0.56
法尔斯布	-0.41	-0.57
ankrd46	-0.41	-0.56

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005515	蛋白质结合	IPI		10618369\|14732692
去：0008201	肝素约束	IEA		-
GO:0008083	生长因子活性	IEA		-
GO:0008083	生长因子活性	TAS		1693186
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0001525	血管生成	IEA		-
GO:0001759	induction of an organ	IEA		-
GO:0007165	信号转导	nas		3778488
GO:0008283	cell proliferation	IEA		-
去：0008543	fibroblast growth factor receptor signaling pathway	经验		17133345
去：0009653	解剖结构形态发生	TAS		1693186
GO:0007275	multicellular organismal development	TAS		10903182
GO:0030154	细胞分化	IEA		-
GO：0030324	肺发展	IEA		-
去：0050679	上皮细胞增殖的阳性调节	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005576	细胞外区域	经验		1697263\|8622701\|9139660 \|11294897\|16597617
去：0005578	proteinaceous extracellular matrix	IEA		-
去：0005615	细胞外空间	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
CSNK2A1	CK2A1 \| CKII	酪蛋白激酶2，α1多肽	-	HPRD,BioGRID	12145206
CSNK2A2	CK2A2 \|CSNK2A1 \|FLJ43934	酪蛋白激酶2，α素多肽	-	HPRD,BioGRID	12145206
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	酪蛋白激酶2，β多肽	-	HPRD,BioGRID	12145206
FGF1	AFGF \|ECGF \|ECGF-beta \|ECGFA \|ECGFB \|fgf-alpha \|fgfa \|glio703 \|HBGF1	fibroblast growth factor 1 (acidic)	-	HPRD,BioGRID	9655399 \| 11069186
FGFBP1	FGFBP \|HBP17	fibroblast growth factor binding protein 1	-	HPRD,BioGRID	11509569
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	成纤维细胞生长因子受体1	共晶结构重构的复合物	Biogrid	8576175\|11030354
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	成纤维细胞生长因子受体1	-	HPRD	10336501\|11032250
FGFR2	BEK \| BFR-1 \| CD332 \| CEK3 \| CFD1 \| ECT1 \| FLJ98662 \| JWS \| K-SAM \| KGFR \| TK14 \| TK25	成纤维细胞生长因子受体2	-	HPRD	10618369 \| 11069186
FGFR2	BEK \| BFR-1 \| CD332 \| CEK3 \| CFD1 \| ECT1 \| FLJ98662 \| JWS \| K-SAM \| KGFR \| TK14 \| TK25	成纤维细胞生长因子受体2	共晶结构重构的复合物	Biogrid	8576175\|10618369 \|11069186
FGFR3	ACH \| CD333 \| CEK2 \| HSFGFR3EX \| JTK4	成纤维细胞生长因子受体3	-	HPRD,BioGRID	10574949
FGFR4	CD334 \|JTK2 \|MGC20292 \|TKF	成纤维细胞生长因子受体4	-	HPRD,BioGRID	10336501\|10736564
fibp	fgfibp \|FIBP-1	成纤维细胞生长因子（酸性）细胞内结合蛋白	-	HPRD,BioGRID	9806903
HSPA9	CSA \| GRP75 \| HSPA9B \| MGC4500 \| MOT \| MOT2 \| MTHSP75 \| PBP74 \| mot-2	热休克70KDA蛋白9（lortalin）	-	HPRD,BioGRID	10510314
NRP1	BDCA4 \|CD304 \|DKFZP686A03134 \|DKFZP781F1414 \|NP1 \|NRP \|VEGF165R	Neuropilin 1	NRP1 (Npn-1) interacts with FGF1. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF1.	绑定	15695515
S100A13	-	S100钙结合蛋白A13	-	HPRD,BioGRID	9712836\|11432880 \| 11432880
Syt1	DKFZP781D2042 \|p65 \|SVP65 \|Syt	synaptotagmin I	-	HPRD,BioGRID	11432880

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg mapk信号通路	267	205	All SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节	216	144	All SZGR 2.0 genes in this pathway
癌症中的KEGG途径	328	259	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
PID FGF途径	55	37	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	37	24	All SZGR 2.0 genes in this pathway
Reactome胰岛素受体信号传导级联	87	64	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
FGFR2的Reactome激活点突变体	16	11	All SZGR 2.0 genes in this pathway
FGFR1突变体的反应组信号传导	30	20	All SZGR 2.0 genes in this pathway
FGFR1激活点突变体的反应组信号传导	11	8	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导3 MUTANTS	11	9	All SZGR 2.0 genes in this pathway
FGFR突变体的Reactome信号传导	44	29	All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE	36	27	All SZGR 2.0 genes in this pathway
Reactome Pi 3K级联	56	39	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
Reactome磷脂酶C介导的级联	54	40	All SZGR 2.0 genes in this pathway
Reactome SHC介导的级联	28	19	All SZGR 2.0 genes in this pathway
胰岛素受体的反应组信号传导	108	72	All SZGR 2.0 genes in this pathway
REACTOME FGFR LIGAND BINDING AND ACTIVATION	22	15	All SZGR 2.0 genes in this pathway
Reactome FGFR2C配体结合和激活	12	9	All SZGR 2.0 genes in this pathway
Reactome FGFR4配体结合和激活	12	8	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导	112	80	All SZGR 2.0 genes in this pathway
Reactome FGFR1配体结合和激活	14	9	All SZGR 2.0 genes in this pathway
Reactome PI3K级联	71	51	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
Senese HDAC1和HDAC2靶向DN	232	139	All SZGR 2.0 genes in this pathway
Senese HDAC3靶向DN	536	332	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
Kim WT1靶向8小时	164	122	All SZGR 2.0 genes in this pathway
Kim WT1靶向12小时	162	116	All SZGR 2.0 genes in this pathway
甲状腺癌	443	294	All SZGR 2.0 genes in this pathway
奥多内尔转移	82	58	All SZGR 2.0 genes in this pathway
Perez TP53目标	1174	695	All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS DN	8	7	All SZGR 2.0 genes in this pathway
Nuytten Nipp1靶向	769	437	All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向	1037	673	All SZGR 2.0 genes in this pathway
Koyama Sema3b靶向	292	168	All SZGR 2.0 genes in this pathway
HE PTEN TARGETS UP	16	15	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN	357	212	All SZGR 2.0 genes in this pathway
LE EGR2目标DN	108	84	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CHICK	169	111	All SZGR 2.0 genes in this pathway
弗莱赫纳活检肾脏移植被拒绝vs ok dn	546	351	All SZGR 2.0 genes in this pathway
Grandvaux IRF3目标DN	19	14	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN	148	102	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病	1691	1088	All SZGR 2.0 genes in this pathway
大脑衰老	262	186	All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN	434	302	All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY DN	48	33	All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER DN	20	11	All SZGR 2.0 genes in this pathway
肝癌DN中的阿塞维多甲基化	940	425	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN	108	68	All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记	165	118	All SZGR 2.0 genes in this pathway
Hinata NFKB靶向成纤维细胞	84	60	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP	293	203	All SZGR 2.0 genes in this pathway
Mikkelsen IPS LCP带有H3K4Me3	174	100	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
Mikkelsen ES LCP带有H3K4Me3	142	80	All SZGR 2.0 genes in this pathway
Mikkelsen NPC LCP带有H3K4ME3	58	34	All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应14	143	86	All SZGR 2.0 genes in this pathway
Chicas RB1目标增长	243	155	All SZGR 2.0 genes in this pathway
KANG AR TARGETS DN	19	12	All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应	549	316	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN	553	343	All SZGR 2.0 genes in this pathway
Servitja肝HNF1A靶向DN	157	105	All SZGR 2.0 genes in this pathway
Delacroix Rar Bound ES	462	273	All SZGR 2.0 genes in this pathway
NABA分泌因素	344	197	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-143	1432	1438	M8	HSA-MIR-143^brain	UGAGAUGAAGCACUGUAGCUCA

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:FGF1