Gene Page:FGF2

Summary?
GeneID 2247
Symbol FGF2
Synonyms BFGF|FGF-2|FGFB|HBGF-2
Description fibroblast growth factor 2
Reference MIM:134920|HGNC:HGNC:3676|Ensembl:ENSG00000138685|HPRD:00622|Vega:OTTHUMG00000039506
Gene type protein-coding
Map location 4 q26
Pascal p-value 0.114
Fetal beta -1.074
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurancewith Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg12632152 4 123748753 FGF2 6.42E-9 -0.019 3.35E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10409262 chr19 58154954 FGF2 2247 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GLUD1 0.91 0.88
SLC4A4 0.90 0.87
HTRA1 0.89 0.90
NT5E 0.89 0.90
ATP13A4 0.89 0.89
ATP1A2 0.88 0.86
SUCLG2 0.87 0.84
SLC1A3 0.87 0.79
ADHFE1 0.87 0.90
MERTK 0.86 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DUSP12 -0.58 -0.68
MED19 -0.58 -0.67
ZNF821 -0.58 -0.67
BZW2 -0.58 -0.71
MLLT11 -0.57 -0.65
MPP3 -0.57 -0.67
RTF1 -0.57 -0.68
USF1 -0.57 -0.67
SPATS2 -0.57 -0.66
ZBTB8A -0.56 -0.64

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 11075807
GO:0008201 heparin binding IEA -
GO:0008083 growth factor activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0010001 glial cell differentiation IEA Glial (GO term level: 8) -
GO:0007399 nervous system development TAS neurite (GO term level: 5) 9576942
GO:0000186 activation of MAPKK activity IEA -
GO:0000187 activation of MAPK activity TAS 9712850
GO:0001759 induction of an organ IEA -
GO:0001934 positive regulation of protein amino acid phosphorylation IEA -
GO:0007265 Ras protein signal transduction TAS 10848592
GO:0009887 organ morphogenesis TAS 10903182
GO:0007165 signal transduction NAS 9712850
GO:0008285 negative regulation of cell proliferation IEA -
GO:0008543 fibroblast growth factor receptor signaling pathway EXP 17133345
GO:0006935 chemotaxis TAS 10848592
GO:0007275 multicellular organismal development IEA -
GO:0021940 positive regulation of granule cell precursor proliferation IEA -
GO:0030324 lung development IEA -
GO:0045766 positive regulation of angiogenesis IEA -
GO:0050679 positive regulation of epithelial cell proliferation IEA -
GO:0045597 positive regulation of cell differentiation IEA -
GO:0046668 regulation of retinal cell programmed cell death IEA -
GO:0060045 positive regulation of cardiac muscle cell proliferation IDA 9553078
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region EXP 1697263|8622701|9139660
|11294897|16597617
GO:0005576 extracellular region TAS 10490103
GO:0005615 extracellular space TAS 2435575

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
API5 AAC-11 | AAC11 | API5L1 apoptosis inhibitor 5 - HPRD 11075807
CD44 CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1 CD44 molecule (Indian blood group) - HPRD 7532176
CEP57 KIAA0092 | PIG8 | TSP57 centrosomal protein 57kDa - HPRD 12717444
CSNK2A1 CK2A1 | CKII casein kinase 2, alpha 1 polypeptide - HPRD,BioGRID 12145206
CSNK2A2 CK2A2 | CSNK2A1 | FLJ43934 casein kinase 2, alpha prime polypeptide Reconstituted Complex BioGRID 12145206
CSNK2A2 CK2A2 | CSNK2A1 | FLJ43934 casein kinase 2, alpha prime polypeptide - HPRD 7735329
CSNK2B CK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224 casein kinase 2, beta polypeptide Reconstituted Complex BioGRID 12145206
CXCL13 ANGIE | ANGIE2 | BCA-1 | BCA1 | BLC | BLR1L | SCYB13 chemokine (C-X-C motif) ligand 13 - HPRD 11708770
FGFBP1 FGFBP | HBP17 纤维母细胞生长因子结合蛋白1 - HPRD,BioGRID 11509569
FGFR1 BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAM fibroblast growth factor receptor 1 - HPRD,BioGRID 10950949|11030354
FGFR2 BEK | BFR-1 | CD332 | CEK3 | CFD1 | ECT1 | FLJ98662 | JWS | K-SAM | KGFR | TK14 | TK25 fibroblast growth factor receptor 2 - HPRD 10950949
FGFR4 CD334 | JTK2 | MGC20292 | TKF fibroblast growth factor receptor 4 - HPRD 8530375
GPC3 DGSX | OCI-5 | SDYS | SGB | SGBS | SGBS1 glypican 3 - HPRD,BioGRID 12478660
GPC4 K-glypican glypican 4 - HPRD,BioGRID 11066092
HSPG2 PLC | PRCAN | SJA | SJS | SJS1 heparan sulfate proteoglycan 2 - HPRD 11847221
NRP1 BDCA4 | CD304 | DKFZp686A03134 | DKFZp781F1414 | NP1 | NRP | VEGF165R neuropilin 1 NRP1 (Npn-1) interacts with FGF2. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF2. BIND 15695515
PF4 CXCL4 | MGC138298 | SCYB4 platelet factor 4 - HPRD 9558385
RPL6 SHUJUN-2 | TAXREB107 | TXREB1 ribosomal protein L6 - HPRD,BioGRID 9826564
RPS19 DBA ribosomal protein S19 - HPRD,BioGRID 11716516
SDC1 CD138 | SDC | SYND1 | syndecan syndecan 1 Co-purification BioGRID 16982797
SDC2 HSPG | HSPG1 | SYND2 syndecan 2 Co-purification BioGRID 16982797
SDC3 N-syndecan | SDCN | SYND3 syndecan 3 - HPRD,BioGRID 8344959
SDC4 MGC22217 | SYND4 syndecan 4 Co-purification BioGRID 16982797
VTN V75 | VN | VNT vitronectin - HPRD,BioGRID 11796824


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG MELANOMA 71 57 All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 56 45 All SZGR 2.0 genes in this pathway
PID GLYPICAN 1PATHWAY 27 20 All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 50 41 All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 75 53 All SZGR 2.0 genes in this pathway
PID SYNDECAN 4通道 32 25 All SZGR 2.0 genes in this pathway
PID FGF PATHWAY 55 37 All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 37 24 All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 87 64 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
基因点突变体FGFR2 REACTOME激活 16 11 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 MUTANTS 30 20 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 11 8 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR3 MUTANTS 11 9 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS 44 29 All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE 36 27 All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE 56 39 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 54 40 All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED CASCADE 28 19 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 108 72 All SZGR 2.0 genes in this pathway
REACTOME FGFR LIGAND BINDING AND ACTIVATION 22 15 All SZGR 2.0 genes in this pathway
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION 12 9 All SZGR 2.0 genes in this pathway
REACTOME FGFR4 LIGAND BINDING AND ACTIVATION 12 8 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION 14 9 All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE 71 51 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING DN 46 29 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294 178 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN 64 39 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS DN 19 13 All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT1 TARGETS 10 9 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN 98 59 All SZGR 2.0 genes in this pathway
WU CELL MIGRATION 184 114 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290 172 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179 105 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 240 HELA 60 43 All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS 62 46 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS 29 20 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 145 91 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 89 61 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN 86 62 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN 58 43 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN 101 70 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT UP 29 21 All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER 49 30 All SZGR 2.0 genes in this pathway
GEISS RESPONSE TO DSRNA UP 38 29 All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN 51 32 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160 101 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR GAMMA RADIATION 15 13 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP 180 114 All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 115 80 All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 80 66 All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 91 75 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 138 92 All SZGR 2.0 genes in this pathway
JU AGING TERC TARGETS UP 10 6 All SZGR 2.0 genes in this pathway
MIZUKAMI HYPOXIA UP 12 12 All SZGR 2.0 genes in this pathway
MIZUKAMI HYPOXIA DN 6 5 All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP 84 60 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 134 83 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR DN 44 34 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199 143 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 166 97 All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 110 68 All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 86 54 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-103/107 5639 5645 m8 hsa-miR-103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-140 3774 3780 1A hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-15/16/195/424/497 5640 5647 1A,m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-503 5600 5606 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG
hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG