Gene Page:FGF8

Summary?
GeneID 2253
Symbol FGF8
Synonyms AIGF|FGF-8|HBGF-8|HH6|KAL6
Description fibroblast growth factor 8
Reference MIM:600483|HGNC:HGNC:3686|运用:ENSG00000107831|HPRD:02727|
Gene type protein-coding
Map location 10q24
Pascal p-value 5.629E-4
Fetal beta -0.2
eGene 元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TINAGL1 0.82 0.85
HLA-E 0.81 0.83
C1QTNF1 0.79 0.81
BCAM 0.77 0.78
A4GALT 0.75 0.73
FAM38A 0.75 0.72
TBX2 0.75 0.73
APOL3 0.74 0.77
ST6GALNAC1 0.74 0.76
RBPMS 0.74 0.79
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GNL3 -0.66 -0.68
HYLS1 -0.65 -0.68
FAM32A -0.65 -0.71
ASNSD1 -0.65 -0.70
MED19 -0.65 -0.71
GLOD4 -0.65 -0.69
FARSB -0.65 -0.66
PAK1IP1 -0.64 -0.68
FRG1 -0.64 -0.69
ZBED5 -0.64 -0.74

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG MELANOMA 71 57 All SZGR 2.0 genes in this pathway
PID FGF PATHWAY 55 37 All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 37 24 All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 87 64 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED POINT MUTANTS OF FGFR2 16 11 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 MUTANTS 30 20 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 11 8 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR3 MUTANTS 11 9 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS 44 29 All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE 36 27 All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE 56 39 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 54 40 All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED CASCADE 28 19 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 108 72 All SZGR 2.0 genes in this pathway
REACTOME FGFR LIGAND BINDING AND ACTIVATION 22 15 All SZGR 2.0 genes in this pathway
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION 12 9 All SZGR 2.0 genes in this pathway
REACTOME FGFR4 LIGAND BINDING AND ACTIVATION 12 8 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION 14 9 All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE 71 51 All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL DN 118 79 All SZGR 2.0 genes in this pathway
THEODOROU MAMMARY TUMORIGENESIS 31 24 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148 102 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178 121 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269 159 All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 138 99 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222 147 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway