SZGR2 - Beplay体育中心

Summary？

GeneID	2260
Symbol	FGFR1
Synonyms	BFGFR\|CD331\|CEK\|FGFBR\|FGFR-1\|FLG\|FLT-2\|FLT2\|HBGFR\|HH2\|HRTFDS\|KAL2\|N-SAM\|OGD\|bFGF-R-1
Description	成纤维细胞生长因子受体1
Reference	MIM:136350\|HGNC:HGNC:3688\|Ensembl:ENSG00000077782\|HPRD:00634\|Vega:OTTHUMG00000147366
基因类型	蛋白质编码
Map location	8P11.23-P11.22
Pascal p-value	1.709E-6
胎儿β	-0.353

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Association	A combined odds ratio method (Sun等。2008), association studies	1	Link to SZGene
Literature	High-throughput literature-search	与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症	点击显示详细信息
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.015

Section I. Genetics and epigenetics annotation

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TRIB3	0.86	0.86
MGAT4B	0.85	0.87
3月9日	0.85	0.85
CRIP2	0.85	0.85
SCMH1	0.84	0.86
COMTD1	0.83	0.83
C7orf43	0.83	0.81
GPR172A	0.83	0.81
RHOV	0.83	0.84
FAM57B	0.83	0.85

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.27	-0.64	-0.72
MT-CO2	-0.62	-0.69
AF347015.8	-0.61	-0.71
AF347015.33	-0.61	-0.67
mt-cyb	-0.60	-0.69
AF347015.31	-0.60	-0.67
AF347015.15	-0.58	-0.68
AF347015.26	-0.56	-0.69
AF347015.21	-0.56	-0.71
AF347015.2	-0.55	-0.66

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0000166	nucleotide binding	IEA		-
GO:0004872	receptor activity	IEA		-
GO:0005007	fibroblast growth factor receptor activity	nas		1846977\|2159626
GO:0005007	fibroblast growth factor receptor activity	TAS		2167437
去：0005515	蛋白质结合	IPI		8753773\|9660748
去：0005524	ATP binding	nas		-
GO：0016740	转移酶活性	IEA		-
GO:0008201	肝素约束	nas		-
Biological process	去学期	证据	神经关键字	PubMed ID
去：0000165	MAPKKK cascade	TAS		10748122
GO:0001501	skeletal system development	TAS		7874169
GO:0006468	protein amino acid phosphorylation	nas		1846977\|2159626
GO:0016049	cell growth	nas		-
去：0008543	fibroblast growth factor receptor signaling pathway	EXP		17086194
去：0008543	fibroblast growth factor receptor signaling pathway	nas		2159626
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005624	membrane fraction	nas		-
去：0005886	plasma membrane	EXP		9139660\|16597617\|17086194
去：0005887	integral to plasma membrane	TAS		10918587

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
BNIP2	BNIP-2 \|NIP2	BCL2/adenovirus E1B 19kDa interacting protein 2	-	HPRD,BioGRID	10551883
FDPS	FPPS \| FPS	Farnesyl二磷酸合酶（Farnesyl Pyrophophate合成酶，二甲基扬扬基转移酶，香烷基转移酶）	-	HPRD,BioGRID	12020352
FGF1	AFGF \| ECGF \| ECGF-beta \| ECGFA \| ECGFB \| FGF-alpha \| FGFA \| GLIO703 \| HBGF1	fibroblast growth factor 1 (acidic)	共晶结构重构的复合物	Biogrid	8576175\|11030354
FGF1	AFGF \| ECGF \| ECGF-beta \| ECGFA \| ECGFB \| FGF-alpha \| FGFA \| GLIO703 \| HBGF1	fibroblast growth factor 1 (acidic)	-	HPRD	10336501\|11032250
FGF2	BFGF \| FGFB \| HBGF-2	fibroblast growth factor 2 (basic)	-	HPRD,BioGRID	10950949\|11030354
FGF5	HBGF-5 \| Smag-82	fibroblast growth factor 5	-	HPRD,BioGRID	8386828
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	成纤维细胞生长因子受体1	重构的复合物	Biogrid	11030354
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	成纤维细胞生长因子受体1	-	HPRD	8752212
FRS2	FRS2A \| FRS2alpha \| SNT \| SNT-1 \| SNT1	成纤维细胞生长因子受体底物2	-	HPRD,BioGRID	11090629\|11877385
FRS3	FRS2B \| FRS2beta \| MGC17167 \| SNT-2 \| SNT2	成纤维细胞生长因子受体底物3	-	HPRD,BioGRID	9660748\|10629055
FRS3	FRS2B \| FRS2beta \| MGC17167 \| SNT-2 \| SNT2	成纤维细胞生长因子受体底物3	FGFR1 interacts with FRS2-beta.	绑定	10629055
GRB14	-	growth factor receptor-bound protein 14	-	HPRD,BioGRID	10713090
GRB2	灰烬\|EGFRBP-GRB2 \|Grb3-3 \|MST084 \|MSTP084	growth factor receptor-bound protein 2	-	HPRD	9480847
KPNB1	IMB1 \| IPOB \| Impnb \| MGC2155 \| MGC2156 \| MGC2157 \| NTF97	karyopherin (importin) beta 1	-	HPRD,BioGRID	11257130
NCAM1	CD56 \| MSK39 \| NCAM	neural cell adhesion molecule 1	-	HPRD,BioGRID	12121226
NCK2	grb4 \|NCKBETA	NCK adaptor protein 2	FGFR1的未指定同工型与NCK2相互作用。这种相互作用是基于未指定物种和人NCK2的FGFR1之间的相互作用建模的。	绑定	15117958
PIK3R2	P85B \|P85 \|p85-beta	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	An unspecified isoform of FGFR1 interacts with p85-beta. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human p85-beta.	绑定	15117958
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	An unspecified isoform of FGFR1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human PLC-gamma.	绑定	15117958
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	Two-hybrid	Biogrid	9660748
RPS6KA1	HU-1 \| MAPKAPK1A \| RSK \| RSK1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	FGFR1 interacts with RSK1. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human RSK1.	绑定	15117958
RTN1	MGC133250 \| NSP	reticulon 1	An unspecified isoform of FGFR1 interacts with RTN1. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human RTN1.	绑定	15117958
RTN3	ASYIP \| HAP \| NSPL2 \| NSPLII \| RTN3-A1	reticulon 3	An unspecified isoform of FGFR1 interacts with RTN3. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human RTN3.	绑定	15117958
SH3BP2	3BP2 \| CRBM \| CRPM \| FLJ42079 \| RES4-23	SH3-domain binding protein 2	FGFR1的未指定同工型与SH3BP2相互作用。这种相互作用是基于未指定物种和人类SH3BP2的FGFR1之间的相互作用进行建模的。	绑定	15117958
SHB	RP11-3J10.8 \| bA3J10.2	SRC同源性2含有衔接蛋白B的结构域	-	HPRD,BioGRID	7537362
SHB	RP11-3J10.8 \| bA3J10.2	SRC同源性2含有衔接蛋白B的结构域	SHB与FGFR1相互作用	绑定	7537362
SHC1	FLJ26504 \| SHC \| SHCA	SHC（SRC同源性2结构域）转化蛋白1	-	HPRD	7514169
SLA	Sla1 \|拍击	Src-like-adaptor	FGFR1的未指定同工型与Slap相互作用。这种相互作用是基于未指定物种和人类巴掌的FGFR1之间的相互作用进行建模的。	绑定	15117958
TENC1	C1-TEN \| C1TEN \| DKFZp686D13244 \| FLJ16320 \| KIAA1075 \| TNS2	tensin like C1 domain containing phosphatase (tensin 2)	FGFR1的未指定同工型与KIAA1075相互作用。这种相互作用是基于未指定物种与人类KIAA1075的FGFR1之间的相互作用进行建模的。	绑定	15117958

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg mapk信号通路	267	205	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
癌症中的KEGG途径	328	259	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
PID Glypican 1 Pathway	27	20	All SZGR 2.0 genes in this pathway
PID Syndecan 4途径	32	25	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
PID FGF途径	55	37	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	37	24	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导1MUTANTS	30	20	All SZGR 2.0 genes in this pathway
FGFR1激活点突变体的反应组信号传导	11	8	All SZGR 2.0 genes in this pathway
FGFR突变体的Reactome信号传导	44	29	All SZGR 2.0 genes in this pathway
Reactome Axon指导	251	188	All SZGR 2.0 genes in this pathway
Reactome NCAM信号传导，用于神经突的生长	64	49	All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE	36	27	All SZGR 2.0 genes in this pathway
Reactome Pi 3K级联	56	39	All SZGR 2.0 genes in this pathway
REACTOME FGFR下游信号激活	100	74	All SZGR 2.0 genes in this pathway
Reactome磷脂酶C介导的级联	54	40	All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED CASCADE	28	19	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1	34	25	All SZGR 2.0 genes in this pathway
胰岛素受体的反应组信号传导	108	72	All SZGR 2.0 genes in this pathway
REACTOME FGFR LIGAND BINDING AND ACTIVATION	22	15	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导	112	80	All SZGR 2.0 genes in this pathway
Reactome FGFR1配体结合和激活	14	9	All SZGR 2.0 genes in this pathway
Reactome PI3K级联	71	51	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血红斑dn	493	298	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN	116	79	All SZGR 2.0 genes in this pathway
王攀登目标	269	146	All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 16d DN的Takeda目标	143	83	All SZGR 2.0 genes in this pathway
Mullighan MLL签名2 DN	281	186	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
runx1 runx1t1融合单核细胞的TONKS目标	204	140	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN	260	143	All SZGR 2.0 genes in this pathway
Senese HDAC1和HDAC2靶向DN	232	139	All SZGR 2.0 genes in this pathway
Kim WT1靶向8小时	164	122	All SZGR 2.0 genes in this pathway
Kim WT1靶向12小时	162	116	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN	64	39	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP	117	84	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa DN转变	394	258	All SZGR 2.0 genes in this pathway
myllykangas放大热点9	8	6	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 4	16	9	All SZGR 2.0 genes in this pathway
Schlosser血清反应	134	93	All SZGR 2.0 genes in this pathway
斯尼德斯在头部和颈部肿瘤中放大	37	27	All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER	111	69	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
洛佩兹MBD目标	957	597	All SZGR 2.0 genes in this pathway
刘普通癌基因	79	47	All SZGR 2.0 genes in this pathway
Benporath ES 1	379	235	All SZGR 2.0 genes in this pathway
是NPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Benporath Oct4目标	290	172	All SZGR 2.0 genes in this pathway
Benporath SOX2目标	734	436	All SZGR 2.0 genes in this pathway
Benporath NOS目标	179	105	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA	164	118	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8P12 P11 AMPLICON	57	32	All SZGR 2.0 genes in this pathway
尼古斯基在乳腺癌中突变并扩增	94	60	All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上	256	159	All SZGR 2.0 genes in this pathway
SANA对IFNG DN的回应	85	56	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
是CKER TAMOXIFEN RESISTANCE DN	52	37	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 2 UP	14	13	All SZGR 2.0 genes in this pathway
亚伯拉罕ALPC与多发性骨髓瘤	26	22	All SZGR 2.0 genes in this pathway
康（Kang）由tert dn永生	102	67	All SZGR 2.0 genes in this pathway
RADMACHER AML PROGNOSIS	78	52	All SZGR 2.0 genes in this pathway
NPM1突变DN的Verhaak AML	246	180	All SZGR 2.0 genes in this pathway
伊万诺娃造血早期祖先	532	309	All SZGR 2.0 genes in this pathway
HNE和H2O2的Weigel氧化应激	39	29	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病	1691	1088	All SZGR 2.0 genes in this pathway
kaab失败的心房	38	30	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS	49	33	All SZGR 2.0 genes in this pathway
Zhu CMV全部	120	89	All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT UP	29	21	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP	77	57	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP	93	65	All SZGR 2.0 genes in this pathway
霁致癌喀斯特和STK11 DN	17	12	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP	115	80	All SZGR 2.0 genes in this pathway
Rizki肿瘤侵入性3D	210	124	All SZGR 2.0 genes in this pathway
OSADA ASCL1 TARGETS DN	24	20	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN	80	66	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP	294	199	All SZGR 2.0 genes in this pathway
克莱门特乳腺癌复制号码	23	20	All SZGR 2.0 genes in this pathway
lu肿瘤血管生成	25	22	All SZGR 2.0 genes in this pathway
格雷希克癌症复制号码	323	240	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP	165	118	All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记DN	138	92	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE	200	115	All SZGR 2.0 genes in this pathway
MILI假足趋化性DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP	105	75	All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP	166	105	All SZGR 2.0 genes in this pathway
全部难治性治疗	30	18	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
Johnstone Parvb目标3	430	288	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-133	255	261	1A	hsa-miR-133a	uugguccccuucaaccagcugu
miR-133	255	261	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-15/16/195/424/497	886	892	M8	HSA-MIR-15A^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				HSA-MIR-15B^brain	UAGCAGCACAUCAUGGUUUACA
				HSA-MIR-195^SZ	uagcagaaaaauauuggc
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				HSA-MIR-497	cagcagcacacuguguuugu
				HSA-MIR-15A^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				HSA-MIR-15B^brain	UAGCAGCACAUCAUGGUUUACA
				HSA-MIR-195^SZ	uagcagaaaaauauuggc
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				HSA-MIR-497	cagcagcacacuguguuugu
mir-214	1851	1857	M8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
mir-330	521	527	M8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-376	630	636	1A	hsa-miR-376a	aucauagaaaaauccacgu
miR-376	630	636	1A	hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhere查看与大脑相关的miRNA列表。

Gene Page:FGFR1