Gene Page:FKBP1A

Summary?
GeneID 2280
Symbol FKBP1A
Synonyms FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE
Description FK506 binding protein 1A
Reference MIM:186945|HGNC:HGNC:3711|Ensembl:ENSG00000088832|HPRD:01741|Vega:OTTHUMG00000031666
Gene type protein-coding
Map location 20p13
Pascal p-value 0.007
Sherlock p-value 0.702
eGene Myers' cis & trans
Meta
Support RNA AND PROTEIN SYNTHESIS

Gene in Data Sources
Gene set name Method of gene set Description Info
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.025

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs5995385 chr22 37519863 FKBP1A 2280 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KANK2 0.78 0.82
COLEC12 0.77 0.77
TBX18 0.76 0.78
FOXC2 0.76 0.78
ITIH5 0.76 0.85
FLI1 0.71 0.79
GPR124 0.70 0.79
MDS1 0.70 0.72
EVI1 0.69 0.72
CDH5 0.69 0.73
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SNHG12 -0.34 -0.45
ZNF32 -0.33 -0.50
C12orf45 -0.32 -0.49
COX7C -0.32 -0.42
MTIF3 -0.32 -0.43
ST20 -0.31 -0.43
RPS27L -0.31 -0.39
ATP5E -0.31 -0.50
AC132872.1 -0.30 -0.40
RPL41 -0.30 -0.46

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005024 transforming growth factor beta receptor activity TAS 11322937
GO:0004872 receptor activity TAS 7518616
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA -
GO:0005515 protein binding IPI 12604780
GO:0016853 isomerase activity IEA -
GO:0005219 ryanodine-sensitive calcium-release channel activity TAS 11322937
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0003007 heart morphogenesis ISS -
GO:0055010 ventricular cardiac muscle morphogenesis ISS -
GO:0022417 protein maturation via protein folding TAS 11322937
GO:0006457 protein folding IEA -
GO:0006458 'de novo' protein folding TAS 11322937
GO:0042110 T cell activation NAS 1696686
GO:0042026 protein refolding TAS 11322937
GO:0032513 negative regulation of protein phosphatase type 2B activity IDA 7592869
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IMP 12761501
GO:0050776 regulation of immune response IMP 2477715
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005829 cytosol IDA 1701173
GO:0005737 cytoplasm IEA -
GO:0014802 terminal cisterna ISS 1374404

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BMPR1A 10q23del | ACVRLK3 | ALK3 | CD292 bone morphogenetic protein receptor, type IA Two-hybrid BioGRID 9663660
DHFR - dihydrofolate reductase Biochemical Activity BioGRID 12812497
FKBP1A FKBP-12 | FKBP1 | FKBP12 | FKBP12C | PKC12 | PKCI2 | PPIASE FK506 binding protein 1A, 12kDa - HPRD,BioGRID 9871618|10852943
FKBP4 FKBP52 | FKBP59 | HBI | Hsp56 | PPIase | p52 FK506 binding protein 4, 59kDa - HPRD 11164950
FRAP1 FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1 FK506 binding protein 12-rapamycin associated protein 1 - HPRD,BioGRID 8662507
FRAP1 FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1 FK506 binding protein 12-rapamycin associated protein 1 mTOR与FKBP12绑定到雷帕霉素。这s interaction was modeled on a demonstrated interaction between human mTOR and mouse FKBP12. BIND 15467718
GLMN FAP | FAP48 | FAP68 | FKBPAP | GLML | GVM | VMGLOM glomulin, FKBP associated protein - HPRD,BioGRID 8955134
ITPR1 INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16 inositol 1,4,5-triphosphate receptor, type 1 - HPRD,BioGRID 9346894
KIAA1303 - raptor Affinity Capture-Western BioGRID 15268862|15467718
PPP3CA CALN | CALNA | CALNA1 | CCN1 | CNA1 | PPP2B protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform - HPRD 7543369
PPP3R1 CALNB1 | CNB | CNB1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform - HPRD 7541044
RYR1 CCO | MHS | MHS1 | RYDR | RYR | SKRR ryanodine receptor 1 (skeletal) - HPRD,BioGRID 11171121|11279144
|12704193|11237759
RYR3 - ryanodine receptor 3 - HPRD,BioGRID 11171121|11598113
TGFB1I1 ARA55 | HIC-5 | HIC5 | TSC-5 transforming growth factor beta 1 induced transcript 1 - HPRD 12417722
TGFBR1 AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1 transforming growth factor, beta receptor 1 - HPRD,BioGRID 7518616
TGFBR1 AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1 transforming growth factor, beta receptor 1 T-beta-R1 interacts with FKBP12. This interaction was modeled on a demonstrated interaction between T-beta-R1 and FKBP12 both from unspecified species. BIND 15761148
TRPC3 TRP3 瞬时受体电位阳离子channel, subfamily C, member 3 - HPRD 15199065
YY1 DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1 YY1 transcription factor Two-hybrid BioGRID 7541038


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA MTOR PATHWAY 23 15 All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 56 45 All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 54 47 All SZGR 2.0 genes in this pathway
PID ALK1 PATHWAY 26 21 All SZGR 2.0 genes in this pathway
PID ALK2 PATHWAY 11 9 All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY 29 23 All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 33 25 All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY 55 38 All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 7 All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 26 16 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 63 42 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES UP 82 51 All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368 234 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
WIKMAN ASBESTOS LUNG CANCER DN 28 13 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN 45 29 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER LARGE VS TINY UP 44 24 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266 171 All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183 115 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SUBGROUPS 30 20 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 66 48 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN 141 99 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN UP 71 49 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 123 75 All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161 105 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 148 96 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY DN 44 29 All SZGR 2.0 genes in this pathway
WU ALZHEIMER DISEASE UP 14 8 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181 101 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 140 94 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
HOLLEMAN VINCRISTINE RESISTANCE ALL UP 27 16 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-135 467 474 1A,m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-142-3p 659 666 1A,m8 hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
miR-181 139 145 m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-183 226 232 1A hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-218 336 342 1A hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367 1099 1105 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-320 157 163 m8 hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-338 913 919 m8 hsa-miR-338brain UCCAGCAUCAGUGAUUUUGUUGA
miR-369-3p 432 438 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 432 438 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-381 117 123 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-410 434 440 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU