Gene Page:RASA3

Summary?
GeneID 22821
Symbol RASA3
Synonyms GAP1IP4BP|GAPIII
Description RAS p21 protein activator 3
Reference MIM:605182|HGNC:HGNC:20331|Ensembl:ENSG00000185989|HPRD:05537|Vega:OTTHUMG00000017399
Gene type protein-coding
Map location 13q34
Pascal p-value 3.316E-4
Sherlock p-value 0.241
Fetal beta -0.344
DMG 1 (# studies)
eGene Cerebellum
Cortex
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg27503095 13 114793308 RASA3 2.526E-4 0.335 0.037 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RUSC2 0.91 0.91
UBE2O 0.91 0.91
GGA3 0.90 0.91
AP2A2 0.90 0.89
BRSK2 0.90 0.89
USP35 0.90 0.90
AP3D1 0.90 0.90
ASB6 0.90 0.89
MBD1 0.90 0.89
NCLN 0.89 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.75 -0.75
AF347015.31 -0.71 -0.66
MT-CO2 -0.71 -0.66
GNG11 -0.69 -0.72
AF347015.8 -0.69 -0.65
MT-CYB -0.67 -0.61
AF347015.33 -0.67 -0.61
NOSTRIN -0.67 -0.62
AF347015.27 -0.67 -0.64
C1orf54 -0.67 -0.73

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
CHEBOTAEV GR目标DN 120 73 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP 115 78 All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 12P11 12 UP 33 17 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN 57 45 All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE DN 58 39 All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE UP 90 62 All SZGR 2.0 genes in this pathway
阿布得生活信号1 46 29 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 2 72 52 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
MARSHALL VIRAL INFECTION RESPONSE DN 29 21 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
SENGUPTA EBNA1 ANTICORRELATED 173 85 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
DEMAGALHAES AGING UP 55 39 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND WITH H4K20ME1 MARK 145 82 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN 99 74 All SZGR 2.0 genes in this pathway