Summary
基因 22836
象征 Rhobtb3
Synonyms -
Description RHO相关的BTB域包含3个
Reference MIM:607353|HGNC:HGNC:18757|ENSEMBL:ENSG00000164292|HPRD:09557|Vega:Otthumg00000121171
基因类型 蛋白质编码
Map location 5Q15
pascal p-value 0.538
胎儿β 1.167
DMG 1(# studies)

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
CV:PGCnp 全基因组协会研究 GWAS
DMG:Nishioka_2013 全基因组DNA甲基化分析 作者研究了来自18例第一期精神分裂症(FESZ)和15个正常对照的18例外周血细胞中DNA的甲基化谱。 1
PMID:cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
表达 Meta-analysis of gene expression p价值:2.815
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息

Section I. Genetics and epigenetics annotation

@差异甲基化基因

probe 染色体 位置 最近的基因 p(dis) Beta (dis) fdr(dis) 学习
CG11017269 5 95067136 Rhobtb3 -0.03 0.26 DMG:Nishioka_2013


第二节。转录组注释

一般基因表达(GTEX)

无法使用

Devlopment期间的基因表达(BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达(brainspan)

Footnote:
SC:亚皮质区域;SM:感觉运动区域;FC:额叶皮层;和TP:颞顶皮层
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene 皮尔逊的相关性 斯皮尔曼的相关性
ZMYND11 0.86 0.85
USP48 0.86 0.87
DDX42 0.86 0.85
SLC11A2 0.85 0.85
RNF146 0.85 0.85
PDXDC1 0.85 0.86
TTC37 0.85 0.88
TFCP2 0.85 0.85
rabgap1 0.84 0.85
rufy2 0.84 0.86
前10个负共表达基因
Gene 皮尔逊的相关性 斯皮尔曼的相关性
AF347015.21 -0.75 -0.77
AF347015.31 -0.73 -0.76
ifi27 -0.73 -0.73
MT-CO2 -0.73 -0.74
ENHO -0.72 -0.80
FXYD1 -0.72 -0.72
HIGD1B -0.71 -0.73
Metrn -0.71 -0.77
AF347015.27 -0.69 -0.71
VAMP5 -0.69 -0.70

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去:0003924 GTPase activity nas 12426103
去:0005515 蛋白质结合 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
去:0008150 biological_process nd -
去:0008104 protein localization IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去:0005604 basement membrane IEA -
去:0005634 nucleus 艾达 18029348

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
中村肿瘤区周围与中央DN 634 384 All SZGR 2.0 genes in this pathway
Piccaluga血管免疫细胞淋巴瘤 205 140 All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN 92 51 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
turashvili乳房正常导管与小叶DN 7 6 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
ginestier乳腺癌20q13扩增 119 66 All SZGR 2.0 genes in this pathway
胶原蛋白凝胶中的Oswald造血干细胞 233 161 All SZGR 2.0 genes in this pathway
GARGALOVIC应对氧化磷脂灰色DN 74 44 All SZGR 2.0 genes in this pathway
Senese HDAC1靶向DN 260 143 All SZGR 2.0 genes in this pathway
Senese HDAC1和HDAC2靶向DN 232 139 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
Kim WT1目标8小时DN 129 84 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN 209 122 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
甲状腺癌的甲状腺癌间变性 722 443 All SZGR 2.0 genes in this pathway
Gozgit ESR1靶向DN 781 465 All SZGR 2.0 genes in this pathway
甲状腺癌 443 294 All SZGR 2.0 genes in this pathway
chebotaev gr目标dn 120 73 All SZGR 2.0 genes in this pathway
SILIGAN TARGETS OF EWS FLI1 FUSION UP 15 12 All SZGR 2.0 genes in this pathway
Prkca和Ets1的审查目标 16 8 All SZGR 2.0 genes in this pathway
pATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
KANG GIST WITH PDGFRA UP 50 27 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
YANAGIHARA ESX1 TARGETS 30 19 All SZGR 2.0 genes in this pathway
KIM MYCL1扩增靶向 13 11 All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN 637 377 All SZGR 2.0 genes in this pathway
WU细胞迁移 184 114 All SZGR 2.0 genes in this pathway
pASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 All SZGR 2.0 genes in this pathway
Benporath循环基因 648 385 All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标 893 528 All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上 256 159 All SZGR 2.0 genes in this pathway
brocke凋亡由IL6逆转 144 98 All SZGR 2.0 genes in this pathway
史密斯肝癌 45 27 All SZGR 2.0 genes in this pathway
弗莱赫纳活检肾脏移植被拒绝vs ok dn 546 351 All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者 555 346 All SZGR 2.0 genes in this pathway
斯托西对雌二醇的反应 50 35 All SZGR 2.0 genes in this pathway
NPM1定位DN的Alcalay AML 184 132 All SZGR 2.0 genes in this pathway
NPM1突变DN的Verhaak AML 246 180 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN 86 62 All SZGR 2.0 genes in this pathway
罗德韦尔衰老肾脏无血DN 150 93 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
Browne HCMV感染20小时DN 101 70 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 All SZGR 2.0 genes in this pathway
罗德韦尔老化的肾脏DN 145 88 All SZGR 2.0 genes in this pathway
大脑衰老 262 186 All SZGR 2.0 genes in this pathway
伊万诺娃造血细胞和祖细胞 681 420 All SZGR 2.0 genes in this pathway
Wang Smarce1靶向 280 183 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO 38 24 All SZGR 2.0 genes in this pathway
Kyng DNA损伤DN 195 135 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
Massarweh对雌二醇的反应 61 47 All SZGR 2.0 genes in this pathway
OSADA ASCL1靶向 46 30 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存最佳逃亡 246 152 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存次优秀 510 309 All SZGR 2.0 genes in this pathway
Boquest干细胞向上 260 174 All SZGR 2.0 genes in this pathway
西部肾上腺皮质肿瘤 294 199 All SZGR 2.0 genes in this pathway
罗斯白血病与MLL融合 78 49 All SZGR 2.0 genes in this pathway
李最近的胸腺移民 227 128 All SZGR 2.0 genes in this pathway
Croonquist基质刺激DN 13 7 All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION UP 41 26 All SZGR 2.0 genes in this pathway
Gyorffy阿霉素耐药性 56 34 All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤MS DN 46 24 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 162 86 All SZGR 2.0 genes in this pathway
Chicas RB1靶向衰老 572 352 All SZGR 2.0 genes in this pathway
Gabriely miR21靶标 289 187 All SZGR 2.0 genes in this pathway
pasini suz12靶向DN 315 215 All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN 553 343 All SZGR 2.0 genes in this pathway
ewsr1 fli1融合DN的TORCHIA目标 321 200 All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN 1080 713 All SZGR 2.0 genes in this pathway
Delacroix Rarg Bound MEF 367 231 All SZGR 2.0 genes in this pathway
phong tnf响应不是通过p38 337 236 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182 108 All SZGR 2.0 genes in this pathway
Zwang仅通过第一egf脉冲瞬时向上 1839年 928 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-204/211 171 178 1A,M8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
mir-208 165 171 1a hsa-miR-208 auaagacgaaaaaagcuugu
miR-375 176 182 1a HSA-MIR-375 uuuguucguucggcucgcguga
miR-499 165 171 1a HSA-MIR-499 UUAAGACUUGCAGUGAUGUUUAA