Gene Page:RAB11FIP2

Summary?
GeneID 22841
Symbol RAB11FIP2
Synonyms Rab11-FIP2|nRip11
Description RAB11 family interacting protein 2 (class I)
Reference MIM:608599|HGNC:HGNC:29152|Ensembl:ENSG00000107560|HPRD:10548|Vega:OTTHUMG00000019128
Gene type protein-coding
Map location 10q26.11
Pascal p-value 0.414
Sherlock p-value 0.547
Fetal beta -0.352
DMG 1 (# studies)
Support G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02291245 10 119780037 RAB11FIP2 2.269E-4 -0.299 0.036 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某场效应晶体管al (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GRIN2A 0.82 0.74
KCNB1 0.81 0.65
TRHDE 0.81 0.69
PLCB1 0.80 0.59
KLF9 0.80 0.70
CREG2 0.79 0.66
TMEM132D 0.79 0.74
GCC2 0.79 0.74
ARHGAP26 0.79 0.72
CMTM4 0.79 0.68
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BCL7C -0.46 -0.62
AC135586.1 -0.41 -0.53
TRAF4 -0.41 -0.57
UBE2L6 -0.41 -0.46
RPL18 -0.40 -0.62
RPL35 -0.40 -0.57
FAU -0.40 -0.55
RPLP1 -0.40 -0.56
RPL36 -0.40 -0.59
RPS18 -0.40 -0.58

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AP2A1 ADTAA | AP2-ALPHA | CLAPA1 adaptor-related protein complex 2, alpha 1 subunit - HPRD,BioGRID 12364336
EPS15 AF-1P | AF1P | MLLT5 epidermal growth factor receptor pathway substrate 15 Affinity Capture-Western BioGRID 12364336
IL8RB CD182 | CDw128b | CMKAR2 | CXCR2 | IL8R2 | IL8RA interleukin 8 receptor, beta - HPRD,BioGRID 15004234
MYO5B KIAA1119 myosin VB - HPRD,BioGRID 11495908|12393859
RAB11A MGC1490 | YL8 RAB11A, member RAS oncogene family - HPRD 15304524
RAB11A MGC1490 | YL8 RAB11A, member RAS oncogene family - HPRD,BioGRID 11495908|11994279
RAB11B H-YPT3 | MGC133246 RAB11B, member RAS oncogene family - HPRD,BioGRID 11495908
RAB11FIP1 DKFZp686E2214 | FLJ22524 | FLJ22622 | MGC78448 | NOEL1A | RCP | rab11-FIP1 RAB11 family interacting protein 1 (class I) Affinity Capture-Western BioGRID 12364336
RAB11FIP2 KIAA0941 | Rab11-FIP2 | nRip11 RAB11 family interacting protein 2 (class I) Affinity Capture-Western
Two-hybrid		 BioGRID 11994279|12364336
RAB11FIP4 FLJ00131 | KIAA1821 | MGC11316 | MGC126566 | RAB11-FIP4 RAB11 family interacting protein 4 (class II) - HPRD,BioGRID 12470645
RAB11FIP5 DKFZp434H018 | GAF1 | KIAA0857 | RIP11 | pp75 RAB11 family interacting protein 5 (class I) Affinity Capture-Western BioGRID 12364336
RAB25 CATX-8 RAB25, member RAS oncogene family - HPRD,BioGRID 11481332
RAB25 CATX-8 RAB25, member RAS oncogene family - HPRD 11495908
REPS1 RALBP1 RALBP1 associated Eps domain containing 1 Affinity Capture-Western BioGRID 12364336
YWHAG 14-3-3GAMMA tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide - HPRD 15324660


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME AQUAPORIN MEDIATED TRANSPORT 51 34 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 44 30 All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES DN 145 91 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199 124 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN 103 64 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209 137 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176 110 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414 237 All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289 187 All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206 127 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway