Gene Page:CEP164

Summary?
GeneID 22897
Symbol CEP164
Synonyms NPHP15
Description centrosomal protein 164kDa
Reference MIM:614848|HGNC:HGNC:29182|Ensembl:ENSG00000110274|HPRD:10854|Vega:OTTHUMG00000167070
Gene type protein-coding
Map location 11q23.3
Pascal p-value 0.838
Sherlock p-value 0.449
Fetal beta -0.262
eGene Cerebellar Hemisphere
Cerebellum
Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
GSMA_I Genome scan meta-analysis Psr: 0.006

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
CEP164 chr11 117209324 A G NM_001271933
NM_014956		 p.8I>V
p.8I>V		 missense
missense		 Schizophrenia DNM:Fromer_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16955618 chr15 29937543 CEP164 22897 2.441E-4 trans
rs7171526 chr15 62709923 CEP164 22897 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KIAA1715 0.89 0.90
OPA1 0.88 0.91
RAB6A 0.88 0.86
C5orf22 0.88 0.88
RPRD1A 0.88 0.90
ZDHHC17 0.88 0.90
CAB39 0.88 0.88
GDAP1 0.88 0.89
USP14 0.88 0.87
ARMCX3 0.88 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HIGD1B -0.61 -0.62
FXYD1 -0.60 -0.60
CSAG1 -0.58 -0.58
MT-CO2 -0.58 -0.56
AF347015.21 -0.58 -0.53
AF347015.31 -0.57 -0.57
GSDMD -0.57 -0.60
METRN -0.57 -0.60
IFI27 -0.57 -0.59
AF347015.2 -0.57 -0.52

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID ATR PATHWAY 39 25 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 66 43 All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 59 38 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 81 50 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP 82 58 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176 122 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP 93 62 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 483 489 1A hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU