Gene Page:FOXG1

Summary？
基因 2290
象征 FOXG1
Synonyms BF1|BF2|FHKL3|FKH2|FKHL1|FKHL2|FKHL3|FKHL4|FOXG1A|FOXG1B|FOXG1C|HBF-1|HBF-2|HBF-3|HBF-G2|HBF2|HFK1|HFK2|HFK3|KHL2|QIN
Description forkhead box G1
Reference MIM：164874|HGNC：HGNC：3811|HPRD：01283|
基因类型 蛋白质编码
Map location 14q13
Pascal p-value 0.167
Sherlock p-value 0.84
胎儿β 2.6
DMG 1(# studies)

Gene in Data Sources
基因集名称 Method of gene set Description 信息
DMG：JAFFE_2016 全基因组DNA甲基化分析 该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。 1
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
GSMA_I Genome scan meta-analysis Psr: 0.047
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息
go_annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关关键字的命中：5

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
cg21923619 14 29235469 FOXG1 9.88E-9 -0.029 4.33e-6 DMG：JAFFE_2016


第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
FOXC2 0.85 0.62
CFH 0.79 0.58
GJB2 0.78 0.49
SIX2 0.78 0.42
OGN 0.76 0.47
SCARA5 0.75 0.40
DSP 0.75 0.47
SIX1 0.74 0.46
ITGBL1 0.74 0.42
OSR1 0.71 0.38
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
C1orf63 -0.17 -0.17
AC007216.4 -0.16 -0.15
SLC25A41 -0.15 -0.14
SNHG12 -0.15 -0.31
C11orf51 -0.15 -0.21
CRYGS -0.15 -0.10
KCNMB3 -0.14 -0.24
CYP2C8 -0.14 -0.18
npip -0.14 -0.10
DFNB59 -0.14 -0.12

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0003700 转录factor activity TAS -
GO:0043565 sequence-specific DNA binding IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0048667 cell morphogenesis involved in neuron differentiation IEA neuron (GO term level: 10) -
GO：0016199 轴突中线选择点识别 IEA axon (GO term level: 15) -
GO:0030900 前脑发展 IEA Brain (GO term level: 8) -
GO：0021954 中枢神经系统神经元发展 IEA neuron (GO term level: 10) -
GO：0045665 神经元分化的负调节 IEA neuron (GO term level: 10) -
去：0002052 positive regulation of neuroblast proliferation IEA -
去：0006355 调节转录，DNA依赖性的调节 nas -
去：0006350 转录 IEA -
去：0007346 有丝分裂细胞周期的调节 IEA -
去：0009953 背/腹图形成 IEA -
GO:0007275 multicellular organismal development IEA -
GO:0042472 inner ear morphogenesis IEA -
GO：0045787 细胞周期的正调控 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005634 nucleus nas -

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
EEF1G EF1G | GIG35 eukaryotic translation elongation factor 1 gamma Two-hybrid Biogrid 16169070
FOXH1 fast-1 |Fast1 forkhead box H1 - HPRD,BioGRID 10938097
FOXO1 FKH1 | FKHR | FOXO1A 叉子盒O1 FoxO1与FoxG1交互。这种交互是米odelled on an interaction demonstrated between FoxO1 from an unspecified species and mouse FoxG1. 绑定 15084259
FOXO3 AF6Q21 |DKFZP781A0677 |fkhrl1 |fkhrl1p2 |FOXO2 |foxo3a |MGC12739 |MGC31925 叉子盒O3 FoxO3 interacts with FoxG1. 绑定 15084259
FOXO4 AFX |afx1 |MGC120490 |mllt7 叉子盒O4 FOXO4与FOXG1相互作用。这种相互作用是建立在人类FoxO4和小鼠FOXG1之间的相互作用上的模型。 绑定 15084259
GDF9 - 生长分化因子9 Two-hybrid Biogrid 16169070
HDAC1 DKFZP686H12203 |gon-10 |HD1 |RPD3 |RPD3L1 histone deacetylase 1 - HPRD 11238932
HES1 FLJ20408 |hes-1 |HHL |hry |BHLHB39 分裂1的毛茸茸和增强子（果蝇） - HPRD 11238932
JARID1B FLJ10538 | FLJ12459 | FLJ12491 | FLJ16281 | FLJ23670 | KDM5B | PLU-1 | PUT1 | RBBP2H1A Jumonji，在丰富的交互式域1B - HPRD,BioGRID 12657635
SMAD1 BSP1 |JV4-1 |JV41 |madh1 |MADR1 SMAD家庭成员1 - HPRD,BioGRID 11387330
TLE1 ESG |ESG1 |grg1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) - HPRD 11238932
TLE3 ESG |ESG3 |FLJ39460 |grg3 |HST18976 |KIAA1547 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) - HPRD 11238932


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
PID SMAD2 3核途径 82 63 All SZGR 2.0 genes in this pathway
Lee神经Crest干细胞DN 118 79 All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE DN 35 20 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 All SZGR 2.0 genes in this pathway
Dawson TCL1中的甲基化 59 45 All SZGR 2.0 genes in this pathway
通过HIF1A DN的缺氧总缺氧 110 78 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
Benporath EED目标 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
Benporath PRC2目标 652 441 All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED 100 68 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 126 90 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
PAL PRMT5靶向 203 135 All SZGR 2.0 genes in this pathway
Wang LSD1目标 24 14 All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默 461 298 All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应 342 220 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
SCHRAETS MLL TARGETS UP 35 21 All SZGR 2.0 genes in this pathway
李·威尔姆斯肿瘤 27 12 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
Mikkelsen NPC HCP带有H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
Mikkelsen MEF HCP带有H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
Kim所有疾病少突胶质细胞编号corr up 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up 548 370 All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 77 62 All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 DN 17 10 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR UP 33 25 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR DN 30 25 All SZGR 2.0 genes in this pathway
Zwang仅通过第二EGF脉冲瞬时向上 1725 838 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-133 8 14 M8 HSA-MIR-133A uugguccccuucaaccagcugu
HSA-MIR-133B UUGGUCCCCUUCAACCAGCUA
miR-144 835 841 M8 HSA-MIR-144 UACAGUAUAGAUGAUGUACUAG
miR-186 477 483 1a HSA-MIR-186 caaagaauuuugggcuu
miR-200bc/429 315 322 1A，M8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
mir-203.1 259 265 1a hsa-miR-203 ugaaauguuuaggaccacuag
mir-208 813 819 1a hsa-miR-208 auaagacgaaaaaagcuugu
mir-217 313 319 1a hsa-miR-217 uacugcaucagaacugauuggau
mir-25/32/92/363/367 172 178 M8 hsa-miR-25brain Cauugcacuugucucggucuga
hsa-miR-32 uauugcacauacuaaguugc
HSA-MIR-92 uauugcacuugucccgcgcug
HSA-MIR-367 Aauugcacuuuagcaaugga
HSA-MIR-92BSZ uauugcacucgucccgcgcuc
mir-299-5p 746 752 M8 hsa-miR-299-5p ugguuuaccgucccacauacau
mir-30-5p 874 880 M8 HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-330 251 257 M8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-34/449 599 605 M8 hsa-miR-34abrain uggcaguguuaguguguuuu
hsa-miR-34c Aggcaguguaguagcugauugc
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
HSA-MIR-449B AGGCAGUGUAUUGUUAGCUGGC
mir-369-3p 317 324 1A，M8 hsa-miR-369-3p aauauacaugguugaucuuu
miR-374 318 325 1A，M8 HSA-MIR-374 uuauaauacaAccugauaagug
miR-376 880 886 1a HSA-MIR-376A aucauagaaaaauccacgu
HSA-MIR-376B AUCAUAGAGGAAAAUCCAUGUU
mir-378* 70 76 M8 hsa-miR-422b cuggacuuggagagaaggcc
hsa-miR-422a CUGGACUUAGGGUCAGAAGGCC
miR-499 813 819 1a HSA-MIR-499 UUAAGACUUGCAGUGAUGUUUAA
mir-500 170 177 1A，M8 hsa-miR-500 augcaccuggggaggagauucug
mir-543 392 398 1a hsa-miR-543 aaacauucgcggugcacuucu
hsa-miR-543 aaacauucgcggugcacuucu
mir-9 518 525 1A，M8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA