Gene Page:SLC4A1AP

Summary?
GeneID 22950
Symbol SLC4A1AP
Synonyms HLC3
Description solute carrier family 4 member 1 adaptor protein
Reference MIM:602655|HGNC:HGNC:13813|Ensembl:ENSG00000163798|HPRD:04038|Vega:OTTHUMG00000151944
Gene type protein-coding
Map location 2p23.3
Pascal p-value 2.888E-4
Sherlock p-value 0.489
Fetal beta -0.88
DMG 1 (# studies)
eGene Myers' cis & trans
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg09131135 2 27886635 SLC4A1AP 1.92E-8 -0.012 6.75E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10994209 chr10 61877705 SLC4A1AP 22950 0.04 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconceptionweeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CHD2 0.90 0.93
MTR 0.89 0.93
MACF1 0.88 0.91
USP36 0.88 0.91
GOLGB1 0.88 0.91
BOD1L 0.88 0.91
CEP350 0.88 0.92
PCNT 0.88 0.90
UBN2 0.88 0.90
TNRC6A 0.88 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ENHO -0.65 -0.70
C1orf54 -0.65 -0.76
VAMP5 -0.64 -0.71
AF347015.21 -0.64 -0.70
HIGD1B -0.64 -0.69
AF347015.31 -0.63 -0.65
IFI27 -0.63 -0.64
RHOC -0.62 -0.67
GNG11 -0.61 -0.67
IGFBP7 -0.61 -0.67

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206 111 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352 225 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
LASTOWSKA COAMPLIFIED WITH MYCN 43 29 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290 172 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
WANG PROSTATE CANCER ANDROGEN INDEPENDENT 66 37 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 All SZGR 2.0 genes in this pathway