创e Page:P2RX2
Summary？
| 基因 | 22953 |
| 象征 | P2RX2 |
| Synonyms | DFNA41 | P2X2 |
| Description | 嘌呤能受体P2X 2 |
| Reference | MIM:600844|HGNC：HGNC：15459|ENSEMBL：ENSG00000187848|HPRD：15984|Vega：Otthumg00000168018 |
| 基因类型 | 蛋白质编码 |
| Map location | 12q24.33 |
| pascal p-value | 0.031 |
| 主持人 | 前扣带回皮层BA24 皮质 Frontal Cortex BA9 |
创e in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:PGCnp | 全基因组协会研究 | GWAS | |
| 表达 | Meta-analysis of gene expression | p价值：1.413 | |
| go_annotation | 将与神经相关的关键字映射到基因本体论注释 | 与神经相关的关键字的命中：1 |
Section I. Genetics and epigenetics annotation
EQTL注释
EQTL注释| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | PVALUE | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS4469975 | 12 | 133169007 | P2RX2 | ENSG00000187848.8 | 2.261E-6 | 0.01 | -26359 | gtex_brain_ba24 |
| RS4883630 | 12 | 133200087 | P2RX2 | ENSG00000187848.8 | 1.661E-6 | 0.01 | 4721 | gtex_brain_ba24 |
| RS4883543 | 12 | 133202004 | P2RX2 | ENSG00000187848.8 | 1.016E-6 | 0.01 | 6638 | gtex_brain_ba24 |
| RS12230022 | 12 | 133205160 | P2RX2 | ENSG00000187848.8 | 1.003E-6 | 0.01 | 9794 | gtex_brain_ba24 |
| RS4883541 | 12 | 133205655 | P2RX2 | ENSG00000187848.8 | 1.024E-6 | 0.01 | 10289 | gtex_brain_ba24 |
| RS7485668 | 12 | 133206166 | P2RX2 | ENSG00000187848.8 | 7.746e-7 | 0.01 | 10800 | gtex_brain_ba24 |
| RS5745031 | 12 | 133208611 | P2RX2 | ENSG00000187848.8 | 6.069E-7 | 0.01 | 13245 | gtex_brain_ba24 |
| RS5745028 | 12 | 133208739 | P2RX2 | ENSG00000187848.8 | 6.063E-7 | 0.01 | 13373 | gtex_brain_ba24 |
| RS5745023 | 12 | 13320886 | P2RX2 | ENSG00000187848.8 | 6.078E-7 | 0.01 | 13520 | gtex_brain_ba24 |
| RS5744999 | 12 | 133211753 | P2RX2 | ENSG00000187848.8 | 5.94E-7 | 0.01 | 16387 | gtex_brain_ba24 |
| RS4883624 | 12 | 133212737 | P2RX2 | ENSG00000187848.8 | 3.046e-8 | 0.01 | 17371 | gtex_brain_ba24 |
| RS4883620 | 12 | 133212974 | P2RX2 | ENSG00000187848.8 | 5.967 e - | 0.01 | 17608 | gtex_brain_ba24 |
| RS4883619 | 12 | 133213121 | P2RX2 | ENSG00000187848.8 | 6.202E-7 | 0.01 | 17755 | gtex_brain_ba24 |
| RS4883618 | 12 | 133214130 | P2RX2 | ENSG00000187848.8 | 6.409E-7 | 0.01 | 18764 | gtex_brain_ba24 |
| RS5744976 | 12 | 133214441 | P2RX2 | ENSG00000187848.8 | 2.147E-7 | 0.01 | 19075 | gtex_brain_ba24 |
| RS5744960 | 12 | 133216248 | P2RX2 | ENSG00000187848.8 | 6.207E-7 | 0.01 | 20882 | gtex_brain_ba24 |
| RS4883617 | 12 | 133216617 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 21251 | gtex_brain_ba24 |
| RS4883616 | 12 | 133217245 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 21879 | gtex_brain_ba24 |
| RS10870482 | 12 | 133217346 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 21980 | gtex_brain_ba24 |
| RS4883615 | 12 | 133217872 | P2RX2 | ENSG00000187848.8 | 6.207E-7 | 0.01 | 22506 | gtex_brain_ba24 |
| RS5744951 | 12 | 133218724 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 23358 | gtex_brain_ba24 |
| RS5744944 | 12 | 133219831 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 24465 | gtex_brain_ba24 |
| rs199894653 | 12 | 133220991 | P2RX2 | ENSG00000187848.8 | 4.754e-7 | 0.01 | 25625 | gtex_brain_ba24 |
| RS5744931 | 12 | 133220992 | P2RX2 | ENSG00000187848.8 | 5.55e-7 | 0.01 | 25626 | gtex_brain_ba24 |
| RS10781626 | 12 | 133222644 | P2RX2 | ENSG00000187848.8 | 1.348E-7 | 0.01 | 27278 | gtex_brain_ba24 |
| rs7958381 | 12 | 133222861 | P2RX2 | ENSG00000187848.8 | 1.348E-7 | 0.01 | 27495 | gtex_brain_ba24 |
| RS56380194 | 12 | 133223390 | P2RX2 | ENSG00000187848.8 | 1.337E-7 | 0.01 | 28024 | gtex_brain_ba24 |
| RS7973238 | 12 | 133223642 | P2RX2 | ENSG00000187848.8 | 1.346E-7 | 0.01 | 28276 | gtex_brain_ba24 |
| RS7954928 | 12 | 133224393 | P2RX2 | ENSG00000187848.8 | 5.919E-7 | 0.01 | 29027 | gtex_brain_ba24 |
| RS7974140 | 12 | 133224410 | P2RX2 | ENSG00000187848.8 | 5.919E-7 | 0.01 | 29044 | gtex_brain_ba24 |
| RS4883538 | 12 | 133225446 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 30080 | gtex_brain_ba24 |
| RS4883537 | 12 | 133226196 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 30830 | gtex_brain_ba24 |
| rs59292205 | 12 | 133227555 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 32189 | gtex_brain_ba24 |
| RS7956850 | 12 | 133227619 | P2RX2 | ENSG00000187848.8 | 6.207E-7 | 0.01 | 32253 | gtex_brain_ba24 |
| rs7957171 | 12 | 133227827 | P2RX2 | ENSG00000187848.8 | 5.976E-7 | 0.01 | 32461 | gtex_brain_ba24 |
| RS6560895 | 12 | 133228117 | P2RX2 | ENSG00000187848.8 | 6.204E-7 | 0.01 | 32751 | gtex_brain_ba24 |
| RS6560896 | 12 | 133228453 | P2RX2 | ENSG00000187848.8 | 6.207E-7 | 0.01 | 33087 | gtex_brain_ba24 |
| RS200223728 | 12 | 133230442 | P2RX2 | ENSG00000187848.8 | 1.123E-7 | 0.01 | 35076 | gtex_brain_ba24 |
| RS71076465 | 12 | 133230445 | P2RX2 | ENSG00000187848.8 | 1.102E-7 | 0.01 | 35079 | gtex_brain_ba24 |
| RS56366286 | 12 | 133230451 | P2RX2 | ENSG00000187848.8 | 1.101E-7 | 0.01 | 35085 | gtex_brain_ba24 |
| rs7135759 | 12 | 133232405 | P2RX2 | ENSG00000187848.8 | 1.325E-7 | 0.01 | 37039 | gtex_brain_ba24 |
| RS7303791 | 12 | 133232594 | P2RX2 | ENSG00000187848.8 | 1.644e-7 | 0.01 | 37228 | gtex_brain_ba24 |
| rs5744884 | 12 | 133234389 | P2RX2 | ENSG00000187848.8 | 5.918E-7 | 0.01 | 39023 | gtex_brain_ba24 |
| rs201668602 | 12 | 133234392 | P2RX2 | ENSG00000187848.8 | 2.115E-6 | 0.01 | 39026 | gtex_brain_ba24 |
| RS10687579 | 12 | 133234741 | P2RX2 | ENSG00000187848.8 | 2.343E-7 | 0.01 | 39375 | gtex_brain_ba24 |
| RS5744874 | 12 | 133235157 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 39791 | gtex_brain_ba24 |
| RS5744867 | 12 | 133235789 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 40423 | gtex_brain_ba24 |
| RS5744857 | 12 | 133236000 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 40634 | gtex_brain_ba24 |
| RS5744853 | 12 | 133236425 | P2RX2 | ENSG00000187848.8 | 1.917E-7 | 0.01 | 41059 | gtex_brain_ba24 |
| RS5744844 | 12 | 133238076 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 42710 | gtex_brain_ba24 |
| rs7489112 | 12 | 133238679 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 43313 | gtex_brain_ba24 |
| RS5744838 | 12 | 133240181 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 44815 | gtex_brain_ba24 |
| RS4883592 | 12 | 133240782 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 45416 | gtex_brain_ba24 |
| RS4883586 | 12 | 133242140 | P2RX2 | ENSG00000187848.8 | 6.207E-7 | 0.01 | 46774 | gtex_brain_ba24 |
| RS4883579 | 12 | 133242795 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 47429 | gtex_brain_ba24 |
| RS5744811 | 12 | 133243226 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 47860 | gtex_brain_ba24 |
| RS5744810 | 12 | 133243281 | P2RX2 | ENSG00000187848.8 | 5.942E-7 | 0.01 | 47915 | gtex_brain_ba24 |
| rs5744808 | 12 | 133243347 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 47981 | gtex_brain_ba24 |
| rs5744805 | 12 | 133243650 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 48284 | gtex_brain_ba24 |
| RS4883577 | 12 | 133243788 | P2RX2 | ENSG00000187848.8 | 6.207E-7 | 0.01 | 48422 | gtex_brain_ba24 |
| RS5744798 | 12 | 133245149 | P2RX2 | ENSG00000187848.8 | 1.393E-7 | 0.01 | 49783 | gtex_brain_ba24 |
| RS5744792 | 12 | 133246468 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 51102 | gtex_brain_ba24 |
| RS5744791 | 12 | 133246543 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 51177 | gtex_brain_ba24 |
| RS11146998 | 12 | 133246859 | P2RX2 | ENSG00000187848.8 | 1.069E-6 | 0.01 | 51493 | gtex_brain_ba24 |
| RS5744789 | 12 | 133247985 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 52619 | gtex_brain_ba24 |
| RS5744783 | 12 | 133249017 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 53651 | gtex_brain_ba24 |
| RS5744780 | 12 | 133249139 | P2RX2 | ENSG00000187848.8 | 6.207E-7 | 0.01 | 53773 | gtex_brain_ba24 |
| RS4883555 | 12 | 133250118 | P2RX2 | ENSG00000187848.8 | 5.969E-7 | 0.01 | 54752 | gtex_brain_ba24 |
| RS5744774 | 12 | 133250442 | P2RX2 | ENSG00000187848.8 | 1.353E-7 | 0.01 | 55076 | gtex_brain_ba24 |
| RS5744772 | 12 | 133250569 | P2RX2 | ENSG00000187848.8 | 6.207E-7 | 0.01 | 55203 | gtex_brain_ba24 |
| rs5744767 | 12 | 133250789 | P2RX2 | ENSG00000187848.8 | 1.673E-7 | 0.01 | 55423 | gtex_brain_ba24 |
| RS4883545 | 12 | 133252556 | P2RX2 | ENSG00000187848.8 | 7.172E-7 | 0.01 | 57190 | gtex_brain_ba24 |
| RS5744757 | 12 | 133253310 | P2RX2 | ENSG00000187848.8 | 6.205E-7 | 0.01 | 57944 | gtex_brain_ba24 |
| rs5744750 | 12 | 133254083 | P2RX2 | ENSG00000187848.8 | 6.203E-7 | 0.01 | 58717 | gtex_brain_ba24 |
| RS5744745 | 12 | 133255792 | P2RX2 | ENSG00000187848.8 | 1.352E-7 | 0.01 | 60426 | gtex_brain_ba24 |
| RS201048902 | 12 | 133257998 | P2RX2 | ENSG00000187848.8 | 8.533e-7 | 0.01 | 62632 | gtex_brain_ba24 |
| RS5744732 | 12 | 133257999 | P2RX2 | ENSG00000187848.8 | 1.108E-7 | 0.01 | 62633 | gtex_brain_ba24 |
| RS5744731 | 12 | 133258088 | P2RX2 | ENSG00000187848.8 | 1.342E-7 | 0.01 | 62722 | gtex_brain_ba24 |
| rs202203409 | 12 | 133258884 | P2RX2 | ENSG00000187848.8 | 9.387E-7 | 0.01 | 63518 | gtex_brain_ba24 |
| RS61693359 | 12 | 133258897 | P2RX2 | ENSG00000187848.8 | 1.681E-6 | 0.01 | 63531 | gtex_brain_ba24 |
| RS7307845 | 12 | 133259157 | P2RX2 | ENSG00000187848.8 | 1.267E-6 | 0.01 | 63791 | gtex_brain_ba24 |
| RS4128449 | 12 | 133259920 | P2RX2 | ENSG00000187848.8 | 1.351E-7 | 0.01 | 64554 | gtex_brain_ba24 |
| RS9630293 | 12 | 133260288 | P2RX2 | ENSG00000187848.8 | 6.202E-7 | 0.01 | 64922 | gtex_brain_ba24 |
| RS11147003 | 12 | 133260381 | P2RX2 | ENSG00000187848.8 | 1.351E-7 | 0.01 | 65015 | gtex_brain_ba24 |
| RS12422492 | 12 | 133261750 | P2RX2 | ENSG00000187848.8 | 1.703E-7 | 0.01 | 66384 | gtex_brain_ba24 |
| RS11609235 | 12 | 133262922 | P2RX2 | ENSG00000187848.8 | 7.153E-7 | 0.01 | 67556 | gtex_brain_ba24 |
| RS2075784 | 12 | 133263825 | P2RX2 | ENSG00000187848.8 | 2.888E-7 | 0.01 | 68459 | gtex_brain_ba24 |
| rs11538534 | 12 | 133264332 | P2RX2 | ENSG00000187848.8 | 2.395E-6 | 0.01 | 68966 | gtex_brain_ba24 |
| RS35839450 | 12 | 133269053 | P2RX2 | ENSG00000187848.8 | 1.921E-6 | 0.01 | 73687 | gtex_brain_ba24 |
| RS10781627 | 12 | 133272380 | P2RX2 | ENSG00000187848.8 | 3.726E-7 | 0.01 | 77014 | gtex_brain_ba24 |
| rs7135610 | 12 | 133273255 | P2RX2 | ENSG00000187848.8 | 4.497E-7 | 0.01 | 77889 | gtex_brain_ba24 |
| RS12370832 | 12 | 133274145 | P2RX2 | ENSG00000187848.8 | 9.356e-7 | 0.01 | 78779 | gtex_brain_ba24 |
| RS10870493 | 12 | 133275050 | P2RX2 | ENSG00000187848.8 | 3.651E-7 | 0.01 | 79684 | gtex_brain_ba24 |
| RS10870494 | 12 | 133276284 | P2RX2 | ENSG00000187848.8 | 7.895e-8 | 0.01 | 80918 | gtex_brain_ba24 |
| RS7131963 | 12 | 133278634 | P2RX2 | ENSG00000187848.8 | 3.595E-7 | 0.01 | 83268 | gtex_brain_ba24 |
| RS10781629 | 12 | 133280243 | P2RX2 | ENSG00000187848.8 | 3.595E-7 | 0.01 | 84877 | gtex_brain_ba24 |
| RS10781630 | 12 | 133280352 | P2RX2 | ENSG00000187848.8 | 1.134E-6 | 0.01 | 84986 | gtex_brain_ba24 |
| rs10007 | 12 | 133281462 | P2RX2 | ENSG00000187848.8 | 3.571E-7 | 0.01 | 86096 | gtex_brain_ba24 |
| rs59514433 | 12 | 133282320 | P2RX2 | ENSG00000187848.8 | 3.934E-7 | 0.01 | 86954 | gtex_brain_ba24 |
| RS61952133 | 12 | 133282353 | P2RX2 | ENSG00000187848.8 | 2.083E-6 | 0.01 | 86987 | gtex_brain_ba24 |
| RS10870495 | 12 | 133282661 | P2RX2 | ENSG00000187848.8 | 4.739E-7 | 0.01 | 87295 | gtex_brain_ba24 |
| RS10870496 | 12 | 133282703 | P2RX2 | ENSG00000187848.8 | 1.785E-6 | 0.01 | 87337 | gtex_brain_ba24 |
| rs7965904 | 12 | 133286077 | P2RX2 | ENSG00000187848.8 | 4.11E-7 | 0.01 | 90711 | gtex_brain_ba24 |
第二节。转录组注释
一般基因表达（GTEX）
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| 前10个积极共表达的基因 | ||
| 创e | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
| Zmym2 | 0.95 | 0.96 |
| pDS5A | 0.94 | 0.96 |
| FBXO11 | 0.94 | 0.96 |
| BCLAF1 | 0.94 | 0.97 |
| C4ORF41 | 0.94 | 0.96 |
| thumpd1 | 0.94 | 0.95 |
| AP1G1 | 0.94 | 0.95 |
| TP53BP1 | 0.94 | 0.95 |
| PUM2 | 0.93 | 0.95 |
| UBA6 | 0.93 | 0.95 |
| 前10个负共表达基因 | ||
| 创e | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
| FXYD1 | -0.79 | -0.86 |
| AF347015.31 | -0.79 | -0.87 |
| MT-CO2 | -0.78 | -0.87 |
| AF347015.33 | -0.76 | -0.82 |
| HIGD1B | -0.75 | -0.85 |
| AF347015.27 | -0.75 | -0.83 |
| AF347015.8 | -0.74 | -0.85 |
| mt-cyb | -0.74 | -0.83 |
| ifi27 | -0.74 | -0.83 |
| HSD17B14 | -0.74 | -0.78 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| GO：0015276 | 配体门控离子通道活性 | TAS | 神经递质（GO期限：8） | 9119082 |
| GO:0001614 | purinergic nucleotide receptor activity | nas | 17895406 | |
| GO:0004872 | 受体活性 | IEA | - | |
| GO:0004931 | ATP门控阳离子通道活性 | nas | 17895406 | |
| 去：0005524 | ATP结合 | IEA | - | |
| GO：0042803 | 蛋白质同构化活性 | nas | 17895406 | |
| GO：0046982 | 蛋白质异二聚化活性 | nas | 17895406 | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO：0010524 | 钙离子转运到细胞质的阳性调节 | nas | 17895406 | |
| 去：0006811 | ion transport | IEA | - | |
| GO:0050850 | 钙介导的信号传导的阳性调节 | nas | 17895406 | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0016020 | membrane | IEA | - | |
| GO：0016021 | 膜不可或缺 | IEA | - |
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0 genes in pathway | 信息 |
|---|---|---|---|
| kegg钙信号通路 | 178 | 134 | All SZGR 2.0 genes in this pathway |
| KEGG神经活性配体受体相互作用 | 272 | 195 | All SZGR 2.0 genes in this pathway |
| 带有E盒的WEI MYCN目标 | 795 | 478 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 12Q24 AMPLICON | 15 | 7 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| Meissner Brain HCP带有H3K4ME3和H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| Tavazoie转移 | 108 | 68 | All SZGR 2.0 genes in this pathway |
| Stambolsky对维生素D3的反应 | 84 | 48 | All SZGR 2.0 genes in this pathway |
| 双龙血清敏感基因 | 90 | 54 | All SZGR 2.0 genes in this pathway |
| Zwang仅通过第二EGF脉冲瞬时向上 | 1725 | 838 | All SZGR 2.0 genes in this pathway |