Gene Page:KDM2A

Summary?
GeneID 22992
Symbol KDM2A
Synonyms CXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINA
Description lysine demethylase 2A
Reference MIM:605657|HGNC:HGNC:13606|Ensembl:ENSG00000173120|HPRD:05741|Vega:OTTHUMG00000167103
Gene type protein-coding
Map location 11q13.2
Pascal p-value 0.386
Sherlock p-value 0.369
Fetal beta 0.155
DMG 1 (# studies)
eGene Myers' cis & trans
Support Chromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21293464 11 66885276 KDM2A 2.082E-4 0.288 0.035 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 KDM2A 22992 0.01 trans
rs16955618 chr15 29937543 KDM2A 22992 0.03 trans
rs17264923 chrX 69499164 KDM2A 22992 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EGR2 0.89 0.81
CX3CL1 0.82 0.83
EGR1 0.80 0.81
GPR26 0.79 0.68
FMNL1 0.79 0.84
TMEM132D 0.77 0.80
COL10A1 0.77 0.61
GRIN2A 0.76 0.78
NR4A1 0.76 0.74
CTSB 0.76 0.80
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HEBP2 -0.39 -0.69
GPR125 -0.38 -0.42
UBE2L6 -0.37 -0.38
BCL7C -0.36 -0.53
FADS2 -0.36 -0.39
RPL23A -0.36 -0.53
TUBB2B -0.36 -0.46
TRAF4 -0.36 -0.46
KIAA1949 -0.35 -0.35
DYNLT1 -0.35 -0.55

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM DN 42 26 All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 126 78 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
PATTERSON DOCETAXEL RESISTANCE 29 20 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214 139 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223 140 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 123 86 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210 141 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227 151 All SZGR 2.0 genes in this pathway