Gene Page:ALDOC
Summary?
| GeneID | 230 |
| Symbol | ALDOC |
| Synonyms | ALDC |
| Description | aldolase, fructose-bisphosphate C |
| Reference | MIM:103870|HGNC: HGNC:418|Ensembl:ENSG00000109107|HPRD:02386|Vega:OTTHUMG00000132605 |
| Gene type | protein-coding |
| Map location | 17cen-q12 |
| Pascal p-value | 0.307 |
| Sherlock p-value | 0.766 |
| Fetal beta | -3.002 |
| eGene | Myers' cis & trans |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_clathrin G2Cdb.human_mGluR5 G2Cdb.human_Synaptosome G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets Potential synaptic genes |
基因数据urces
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs631905 | chr17 | 26883312 | ALDOC | 230 | 0.11 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | IEA | - | |
| GO:0004332 | fructose-bisphosphate aldolase activity | TAS | 3105602 | |
| GO:0016829 | lyase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006096 | glycolysis | IEA | - | |
| GO:0006000 | fructose metabolic process | TAS | 3105602 | |
| GO:0008152 | metabolic process | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005739 | mitochondrion | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCOLYSIS GLUCONEOGENESIS | 62 | 41 | 所有SZGR 2.0基因通路 |
| KEGG PENTOSE PHOSPHATE PATHWAY | 27 | 14 | 所有SZGR 2.0基因通路 |
| KEGG FRUCTOSE AND MANNOSE METABOLISM | 34 | 23 | 所有SZGR 2.0基因通路 |
| REACTOME GLYCOLYSIS | 29 | 18 | 所有SZGR 2.0基因通路 |
| REACTOME GLUCONEOGENESIS | 34 | 21 | 所有SZGR 2.0基因通路 |
| REACTOME METABOLISM OF CARBOHYDRATES | 247 | 154 | 所有SZGR 2.0基因通路 |
| REACTOME GLUCOSE METABOLISM | 69 | 42 | 所有SZGR 2.0基因通路 |
| GARY CD5 TARGETS UP | 473 | 314 | 所有SZGR 2.0基因通路 |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | 所有SZGR 2.0基因通路 |
| BASAKI YBX1 TARGETS DN | 384 | 230 | 所有SZGR 2.0基因通路 |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN | 275 | 168 | 所有SZGR 2.0基因通路 |
| AKL HTLV1 INFECTION UP | 27 | 16 | 所有SZGR 2.0基因通路 |
| ELVIDGE HYPOXIA UP | 171 | 112 | 所有SZGR 2.0基因通路 |
| ELVIDGE HYPOXIA BY DMOG UP | 130 | 85 | 所有SZGR 2.0基因通路 |
| ELVIDGE HIF1A TARGETS DN | 91 | 58 | 所有SZGR 2.0基因通路 |
| ELVIDGE HIF1A AND HIF2A TARGETS DN | 104 | 72 | 所有SZGR 2.0基因通路 |
| LANDIS BREAST CANCER PROGRESSION UP | 44 | 27 | 所有SZGR 2.0基因通路 |
| MARKEY RB1 ACUTE LOF UP | 215 | 137 | 所有SZGR 2.0基因通路 |
| CONCANNON APOPTOSIS BY EPOXOMICIN DN | 172 | 112 | 所有SZGR 2.0基因通路 |
| LANDIS ERBB2 BREAST TUMORS 324 UP | 150 | 93 | 所有SZGR 2.0基因通路 |
| MCBRYAN PUBERTAL BREAST 3 4WK UP | 214 | 144 | 所有SZGR 2.0基因通路 |
| MCBRYAN PUBERTAL BREAST 4 5WK UP | 271 | 175 | 所有SZGR 2.0基因通路 |
| HAMAI APOPTOSIS VIA TRAIL DN | 186 | 107 | 所有SZGR 2.0基因通路 |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER UP | 181 | 108 | 所有SZGR 2.0基因通路 |
| RASHI RESPONSE TO IONIZING RADIATION 6 | 84 | 54 | 所有SZGR 2.0基因通路 |
| JOHANSSON BRAIN CANCER EARLY VS LATE DN | 45 | 35 | 所有SZGR 2.0基因通路 |
| GRUETZMANN PANCREATIC CANCER UP | 358 | 245 | 所有SZGR 2.0基因通路 |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | 所有SZGR 2.0基因通路 |
| HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | 所有SZGR 2.0基因通路 |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR DN | 428 | 306 | 所有SZGR 2.0基因通路 |
| COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA UP | 35 | 32 | 所有SZGR 2.0基因通路 |
| NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON | 133 | 78 | 所有SZGR 2.0基因通路 |
| ROZANOV MMP14 TARGETS UP | 266 | 171 | 所有SZGR 2.0基因通路 |
| CERVERA SDHB TARGETS 1 DN | 38 | 22 | 所有SZGR 2.0基因通路 |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP | 87 | 58 | 所有SZGR 2.0基因通路 |
| 阿布得生活信号1 | 46 | 29 | 所有SZGR 2.0基因通路 |
| MENSE缺氧了 | 98 | 71 | 所有SZGR 2.0基因通路 |
| KIM HYPOXIA | 25 | 21 | 所有SZGR 2.0基因通路 |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | 所有SZGR 2.0基因通路 |
| LEE CALORIE RESTRICTION MUSCLE UP | 43 | 33 | 所有SZGR 2.0基因通路 |
| KAAB HEART ATRIUM VS VENTRICLE DN | 261 | 183 | 所有SZGR 2.0基因通路 |
| LEE AGING NEOCORTEX UP | 89 | 59 | 所有SZGR 2.0基因通路 |
| JIANG HYPOXIA NORMAL | 311 | 205 | 所有SZGR 2.0基因通路 |
| SEMENZA HIF1 TARGETS | 36 | 32 | 所有SZGR 2.0基因通路 |
| LEIN ASTROCYTE MARKERS | 42 | 35 | 所有SZGR 2.0基因通路 |
| LEIN MIDBRAIN MARKERS | 82 | 55 | 所有SZGR 2.0基因通路 |
| GAVIN FOXP3 TARGETS CLUSTER P3 | 160 | 103 | 所有SZGR 2.0基因通路 |
| STEIN ESRRA TARGETS UP | 388 | 234 | 所有SZGR 2.0基因通路 |
| HELLER HDAC TARGETS UP | 317 | 208 | 所有SZGR 2.0基因通路 |
| HELLER HDAC TARGETS SILENCED BY METHYLATION UP | 461 | 298 | 所有SZGR 2.0基因通路 |
| COATES MACROPHAGE M1 VS M2 DN | 78 | 44 | 所有SZGR 2.0基因通路 |
| NAKAMURA METASTASIS MODEL DN | 43 | 28 | 所有SZGR 2.0基因通路 |
| WINTER HYPOXIA METAGENE | 242 | 168 | 所有SZGR 2.0基因通路 |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | 所有SZGR 2.0基因通路 |
| HAN SATB1 TARGETS DN | 442 | 275 | 所有SZGR 2.0基因通路 |
| SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE | 81 | 66 | 所有SZGR 2.0基因通路 |
| BOYAULT LIVER CANCER SUBCLASS G2 | 27 | 17 | 所有SZGR 2.0基因通路 |
| STEIN ESRRA TARGETS | 535 | 325 | 所有SZGR 2.0基因通路 |
| WONG EMBRYONIC STEM CELL CORE | 335 | 193 | 所有SZGR 2.0基因通路 |
| WONG ADULT TISSUE STEM MODULE | 721 | 492 | 所有SZGR 2.0基因通路 |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | 所有SZGR 2.0基因通路 |
| MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | 所有SZGR 2.0基因通路 |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 0 | 76 | 54 | 所有SZGR 2.0基因通路 |
| MOOTHA GLUCONEOGENESIS | 32 | 23 | 所有SZGR 2.0基因通路 |
| MOOTHA GLYCOLYSIS | 21 | 13 | 所有SZGR 2.0基因通路 |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | 所有SZGR 2.0基因通路 |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | 所有SZGR 2.0基因通路 |
| HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP | 242 | 159 | 所有SZGR 2.0基因通路 |
| QI HYPOXIA | 140 | 96 | 所有SZGR 2.0基因通路 |
| GREGORY SYNTHETIC LETHAL WITH IMATINIB | 145 | 83 | 所有SZGR 2.0基因通路 |
| PILON KLF1 TARGETS UP | 504 | 321 | 所有SZGR 2.0基因通路 |
| FARDIN HYPOXIA 9 | 7 | 6 | 所有SZGR 2.0基因通路 |
| FARDIN HYPOXIA 11 | 32 | 29 | 所有SZGR 2.0基因通路 |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | 所有SZGR 2.0基因通路 |
| HORTON SREBF TARGETS | 25 | 20 | 所有SZGR 2.0基因通路 |