Gene Page:SPEN

总结?
GeneID 23013
Symbol SPEN
Synonyms HIAA0929|MINT|RBM15C|SHARP
Description spen family transcriptional repressor
Reference MIM:613484|HGNC:HGNC:17575|Ensembl:ENSG00000065526|HPRD:10230|Vega:OTTHUMG00000009376
Gene type protein-coding
Map location 1p36
Pascal p-value 0.204
Sherlock p-value 0.23
Fetal beta 0.94
DMG 1 (# studies)
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg15500658 1 16174610 SPEN -0.024 0.55 DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26conception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
WNK1 0.87 0.89
LAMP1 0.86 0.85
PHLPP1 0.85 0.87
HIATL1 0.85 0.82
ADIPOR2 0.85 0.81
ARHGEF10 0.85 0.85
ATP11A 0.84 0.87
CLN8 0.84 0.86
ABCG1 0.84 0.87
MPDZ 0.84 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM159B -0.52 -0.55
IL32 -0.51 -0.48
AL050337.1 -0.50 -0.38
SYCP3 -0.50 -0.41
ST20 -0.49 -0.51
AF347015.21 -0.49 -0.30
RP9P -0.48 -0.46
SPDYA -0.47 -0.45
C1orf54 -0.47 -0.31
AC087071.1 -0.46 -0.37

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
DLX5 - distal-less homeobox 5 - HPRD 10451362
HDAC1 DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 histone deacetylase 1 - HPRD,BioGRID 11331609
HDAC2 RPD3 | YAF1 histone deacetylase 2 - HPRD 11331609
MBD3 - methyl-CpG binding domain protein 3 - HPRD 11331609
MSX2 CRS2 | FPP | HOX8 | MSH | PFM | PFM1 msh homeobox 2 - HPRD 10451362
MTA2 DKFZp686F2281 | MTA1L1 | PID metastasis associated 1 family, member 2 - HPRD 11331609
NCOR1 KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR nuclear receptor co-repressor 1 - HPRD 11331609
NCOR2 CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 nuclear receptor co-repressor 2 - HPRD,BioGRID 11331609
PAK1 MGC130000 | MGC130001 | PAKalpha p21 protein (Cdc42/Rac)-activated kinase 1 Pak1 phosphorylates SHARP. This interaction was modeled on a demonstrated interaction between Pak1 and SHARP both from an unspecified species. BIND 15824732
PPARD FAAR | MGC3931 | NR1C2 | NUC1 | NUCI | NUCII | PPAR-beta | PPARB peroxisome proliferator-activated receptor delta - HPRD,BioGRID 11867749
RARA NR1B1 | RAR retinoic acid receptor, alpha - HPRD 11331609
RBBP4 NURF55 | RBAP48 retinoblastoma binding protein 4 - HPRD 11331609
RBPJ CBF1 | IGKJRB | IGKJRB1 | KBF2 | MGC61669 | RBP-J | RBPJK | RBPSUH | SUH | csl recombination signal binding protein for immunoglobulin kappa J region - HPRD,BioGRID 12374742
SOX9 CMD1 | CMPD1 | SRA1 SRY (sex determining region Y)-box 9 - HPRD 11331609
SRA1 MGC87674 | SRA | SRAP | STRAA1 | pp7684 steroid receptor RNA activator 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 11331609


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA CARM ER PATHWAY 35 27 All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 59 49 All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 48 39 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177 110 All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158 102 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN 73 51 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP 164 122 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES UP 27 19 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP 48 34 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN 49 29 All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D4 55 37 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318 220 All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP 66 43 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
八木AML和发票16易位 422 277 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 89 57 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE GENES 90 54 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway