Gene Page:SNRNP200
Summary?
| GeneID | 23020 |
| Symbol | SNRNP200 |
| Synonyms | ASCC3L1|BRR2|HELIC2|RP33|U5-200KD |
| Description | small nuclear ribonucleoprotein U5 subunit 200 |
| Reference | MIM:601664|HGNC:HGNC:30859|Ensembl:ENSG00000144028|HPRD:03391|Vega:OTTHUMG00000130455 |
| Gene type | protein-coding |
| Map location | 2q11.2 |
| Pascal p-value | 7.534E-5 |
| Sherlock p-value | 0.504 |
| eGene | Caudate basal ganglia |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0454 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| YTHDF1 | 0.95 | 0.96 |
| KIAA1967 | 0.95 | 0.95 |
| VPS39 | 0.95 | 0.96 |
| ZNF263 | 0.95 | 0.95 |
| USP22 | 0.94 | 0.96 |
| ZFYVE1 | 0.94 | 0.95 |
| FBXO42 | 0.94 | 0.95 |
| USP19 | 0.94 | 0.94 |
| RNF216 | 0.94 | 0.95 |
| QRICH1 | 0.94 | 0.95 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.82 | -0.87 |
| MT-CO2 | -0.81 | -0.87 |
| AF347015.21 | -0.80 | -0.91 |
| AF347015.27 | -0.80 | -0.86 |
| AF347015.8 | -0.79 | -0.85 |
| MT-CYB | -0.78 | -0.83 |
| AF347015.33 | -0.77 | -0.81 |
| HIGD1B | -0.75 | -0.82 |
| AF347015.15 | -0.74 | -0.82 |
| AF347015.2 | -0.74 | -0.81 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0003676 | nucleic acid binding | IEA | - | |
| GO:0005515 | protein binding | 新闻学会 | 9774689|17353931 | |
| GO:0005524 | ATP binding | IC | 9539711 | |
| GO:0016787 | hydrolase activity | IEA | - | |
| GO:0008026 | ATP-dependent helicase activity | IDA | 9539711 | |
| GO:0017111 | nucleoside-triphosphatase activity | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0000354 | cis assembly of pre-catalytic spliceosome | IC | 9539711 | |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | EXP | 12226669 | |
| GO:0008380 | RNA splicing | IDA | 8670905 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005681 | spliceosome | IDA | 8670905 | |
| GO:0005682 | snRNP U5 | IDA | 9539711 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CD2BP2 | FWP010 | LIN1 | Snu40 | U5-52K | CD2 (cytoplasmic tail) binding protein 2 | Affinity Capture-MS | BioGRID | 17353931 |
| MCC | DKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1 | mutated in colorectal cancers | Affinity Capture-MS | BioGRID | 17353931 |
| MEGF10 | DKFZp781K1852 | FLJ41574 | KIAA1780 | multiple EGF-like-domains 10 | - | HPRD | 12421765 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | Affinity Capture-MS | BioGRID | 17353931 |
| PRKAB1 | AMPK | HAMPKb | MGC17785 | protein kinase, AMP-activated, beta 1 non-catalytic subunit | Affinity Capture-MS | BioGRID | 17353931 |
| RNPS1 | E5.1 | MGC117332 | RNA binding protein S1, serine-rich domain | Affinity Capture-MS | BioGRID | 17353931 |
| RNU11 | U11 | RNA, U11 small nuclear | Affinity Capture-MS | BioGRID | 15146077 |
| RNU12 | U12 | RNA, U12 small nuclear | Affinity Capture-MS | BioGRID | 15146077 |
| SMNDC1 | SMNR | SPF30 | survival motor neuron domain containing 1 | - | HPRD,BioGRID | 11331595 |
| SNRNP40 | 40K | FLJ41108 | HPRP8BP | MGC1910 | PRP8BP | PRPF8BP | RP11-490K7.3 | SPF38 | WDR57 | small nuclear ribonucleoprotein 40kDa (U5) | Affinity Capture-MS | BioGRID | 17353931 |
| SNRPB | COD | SNRPB1 | SmB/SmB' | snRNP-B | small nuclear ribonucleoprotein polypeptides B and B1 | Affinity Capture-MS | BioGRID | 17353931 |
| YWHAG | 14-3-3GAMMA | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | Affinity Capture-MS | BioGRID | 17353931 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG SPLICEOSOME | 128 | 72 | All SZGR 2.0 genes in this pathway |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | 140 | 77 | All SZGR 2.0 genes in this pathway |
| REACTOME MRNA PROCESSING | 161 | 86 | All SZGR 2.0 genes in this pathway |
| REACTOME MRNA SPLICING | 111 | 58 | All SZGR 2.0 genes in this pathway |
| REACTOME MRNA SPLICING MINOR PATHWAY | 45 | 19 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER DN | 406 | 230 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE DN | 485 | 334 | All SZGR 2.0 genes in this pathway |
| BARIS THYROID CANCER UP | 23 | 9 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA2 PCC NETWORK | 423 | 265 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | 236 | 139 | All SZGR 2.0 genes in this pathway |
| COLLIS PRKDC SUBSTRATES | 20 | 15 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS UP | 425 | 253 | All SZGR 2.0 genes in this pathway |
| WHITEFORD PEDIATRIC CANCER MARKERS | 116 | 63 | All SZGR 2.0 genes in this pathway |
| JISON SICKLE CELL DISEASE DN | 181 | 97 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH T 9 11 TRANSLOCATION | 130 | 87 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |