Gene Page:MYT1L

概括?
基因 23040
象征 MYT1L
Synonyms MRD39|NZF1|ZC2HC4B
Description 髓鞘转录因子1喜欢
Reference MIM：613084|HGNC:HGNC:7623|ENSEMBL：ENSG00000186487|HPRD:14797|Vega:OTTHUMG00000151407
Gene type protein-coding
Map location 2p25.3
Pascal p-value 0.027
Fetal beta 1.11
DMG 1 (# studies)
Support COMPOSITESET
Darnell FMRP targets

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
CV:PheWAS Phenome-wide association studies (PheWAS) 157 SNPs associated with schizophrenia 1
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与Schizophr Co-occuranceenia keywords: schizophrenia,schizophrenic,schizophrenias 点击to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释

@CV:PheWAS

SNP ID Chromosome Position Allele P 功能 Gene Up/Down Distance
RS2241685 2 1925993 无效的 1.785 MYT1L 无效的

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg10259427 2 1828377 MYT1L 8.78E-5 0.455 0.027 DMG:Wockner_2014
CG04369651 2 1821101 MYT1L 4.509E-4 0.386 0.045 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
OSBPL1A 0.90 0.87
GABRA1 0.89 0.89
GCNT4 0.89 0.77
B4GALT6 0.89 0.85
ATP6V1C1 0.89 0.88
MAPK9 0.88 0.87
PRKCB 0.88 0.90
IQWD1 0.88 0.88
EPS15 0.88 0.82
OXR1 0.88 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BCL7C -0.53 -0.58
FADS2 -0.51 -0.44
NME4 -0.51 -0.61
HYAL2 -0.49 -0.52
SEMA4B -0.49 -0.45
GPR125 -0.48 -0.43
FAM59B -0.46 -0.45
traf4 -0.46 -0.47
SH3BP2 -0.46 -0.50
SH2D2A -0.46 -0.51

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity IEA -
GO:0008270 zinc ion binding IEA -
GO:0046872 metal ion binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0007399 神经系统的发展 IEA neurite (GO term level: 5) -
去：0006355 regulation of transcription, DNA-dependent IEA -
去：0006350 transcription IEA -
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HATADA甲基化在肺癌DN中 38 13 该途径中的所有SZGR 2.0基因
CHEN NEUROBLASTOMA COPY NUMBER GAINS 50 35 该途径中的所有SZGR 2.0基因
SANSOM APC TARGETS DN 366 238 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN 1237 837 该途径中的所有SZGR 2.0基因
PAL PRMT5 TARGETS DN 29 16 该途径中的所有SZGR 2.0基因
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 该途径中的所有SZGR 2.0基因
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 645 651 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
HSA-MIR-206SZ Uggaauguaaggaagugugugg
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-129-5p 538 544 m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
mir-135 714 720 m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b Uauggcuuuucauuccuaugug
miR-141/200a 108 115 1A,m8 hsa-miR-141 uaacacugucugugugugugaugg
HSA-MIR-200A UAACACUGUCUGGUAACGAUGU
mir-15/16/195/424/497 53 59 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d 756 762 m8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
miR-186 321 327 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-30-3p 364 370 m8 hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p cuuucagucggauguauacagc
miR-450 538 544 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
mir-494 516 522 1A hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
mir-495 594 600 m8 hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
mir-496 232 238 m8 hsa-miR-496 AUUACAUGGCCAAUCUC
miR-93.hd/291-3p/294/295/302/372/373/520 755 761 m8 hsa-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU