通用电气ne Page:SMG1

Summary?
通用电气neID 23049
Symbol SMG1
Synonyms 61E3.4|ATX|LIP
Description SMG1 phosphatidylinositol 3-kinase-related kinase
参考 MIM:607032|HGNC:HGNC:30045|运用:ENSG00000157106|HPRD:06123|Vega:OTTHUMG00000166900
通用电气ne type protein-coding
Map location 16 p12.3
Pascal p-value 0.166
Sherlock p-value 0.203
Fetal beta 1.941
eGene Cerebellar Hemisphere
Myers' cis & trans
Support CompositeSet
Darnell FMRP targets
Ascano FMRP targets

通用电气ne in Data Sources
通用电气ne set name Method of gene set Description Info
CV:GWASdb 通用电气nome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp 通用电气nome-wide Association Study GWAS
GSMA_IIE 通用电气nome scan meta-analysis (European-ancestry samples) Psr: 0.01775

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene 通用电气ne Entrez ID pvalue qvalue TSS distance eQTL type
rs1548445 chr16 19691582 SMG1 23049 0.13 cis

Section II. Transcriptome annotation

通用电气neral gene expression (GTEx)

Not available

通用电气ne expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

通用电气ne expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
通用电气ne Pearson's Correlation Spearman's Correlation
ZNF629 0.93 0.93
NAV1 0.93 0.95
ZMIZ1 0.93 0.92
SH3PXD2B 0.93 0.93
DLG5 0.92 0.93
BAT2L 0.92 0.92
KIAA1549 0.91 0.92
JRK 0.91 0.93
ARID1B 0.91 0.93
TBC1D16 0.91 0.90
Top 10 negatively co-expressed genes
通用电气ne Pearson's Correlation Spearman's Correlation
C5orf53 -0.67 -0.77
AF347015.31 -0.66 -0.86
AF347015.27 -0.64 -0.83
MT-CO2 -0.64 -0.84
S100B -0.63 -0.77
FXYD1 -0.63 -0.79
AF347015.33 -0.62 -0.79
IFI27 -0.62 -0.77
HIGD1B -0.62 -0.80
MT-CYB -0.61 -0.80

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 11544179
GO:0004428 inositol or phosphatidylinositol kinase activity IDA 11331269
GO:0004674 protein serine/threonine kinase activity IDA 11544179|15175154
GO:0004674 protein serine/threonine kinase activity NAS 11331269
GO:0016740 transferase activity IEA -
GO:0030145 manganese ion binding IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA 11544179
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay NAS 11331269
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS 16488880
GO:0006406 mRNA export from nucleus TAS 16488880
GO:0006281 DNA repair IEA -
GO:0018105 peptidyl-serine phosphorylation IDA 11544179|15175154
GO:0018105 peptidyl-serine phosphorylation TAS 14636577
GO:0046854 phosphoinositide phosphorylation IDA 11331269
GO:0046777 protein amino acid autophosphorylation IDA 11331269|11544179
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 核 IDA 14636577|15175154
GO:0005737 cytoplasm IC 11331269
GO:0005737 cytoplasm IDA 14636577|15175154

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 176 57 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP 79 50 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238 144 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
PARK HSC VS MULTIPOTENT PROGENITORS UP 19 14 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 102 67 All SZGR 2.0 genes in this pathway
RADMACHER AML PROGNOSIS 78 52 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225 139 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
BILD CTNNB1 ONCOGENIC SIGNATURE 82 52 All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264 168 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D DN 64 35 All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469 239 All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING NOT VIA ATM UP 62 29 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
DING LUNG CANCER BY MUTATION RATE 20 18 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL UP 105 46 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 351 357 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-125/351 175 182 1A,m8 hsa-miR-125b大脑 UCCCUGAGACCCUAACUUGUGA
hsa-miR-125a大脑 UCCCUGAGACCCUUUAACCUGUG
miR-128 888 894 m8 hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-138 4573 4579 m8 hsa-miR-138大脑 AGCUGGUGUUGUGAAUC
miR-142-3p 589 596 1A,m8 hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
miR-216 3147 3153 m8 hsa-miR-216 UAAUCUCAGCUGGCAACUGUG
miR-30-3p 4583 4589 1A hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-329 367 373 1A hsa-miR-329大脑 AACACACCUGGUUAACCUCUUU
miR-33 3432 3439 1A,m8 hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-362 791 797 m8 hsa-miR-362 AAUCCUUGGAACCUAGGUGUGAGU
miR-377 3385 3391 1A hsa-miR-377 AUCACACAAAGGCAACUUUUGU
miR-384 145 151 m8 hsa-miR-384 AUUCCUAGAAAUUGUUCAUA
hsa-miR-384 AUUCCUAGAAAUUGUUCAUA
miR-485-3p 4662 4669 1A,m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-485-5p 59 66 1A,m8 hsa-miR-485-5p AGAGGCUGGCCGUGAUGAAUUC
miR-490 3221 3227 m8 hsa-miR-490 CAACCUGGAGGACUCCAUGCUG
miR-493-5p 867 873 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-504 210 217 1A,m8 hsa-miR-504 AGACCCUGGUCUGCACUCUAU
miR-7 3522 3528 m8 hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG