Gene Page:ZNF609

Summary?
GeneID 23060
Symbol ZNF609
Synonyms -
Description zinc finger protein 609
Reference HGNC:HGNC:29003|Ensembl:ENSG00000180357|HPRD:18754|Vega:OTTHUMG00000172370
Gene type protein-coding
Map location 15q22.31
Pascal p-value 0.003
Sherlock p-value 0.005
Fetal beta 1.634
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
Expression Meta-analysis of gene expression Pvalue: 1.851

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg16639915 15 64960011 ZNF609 2.797E-4 -0.482 0.039 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26所示postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SIRPA 0.87 0.90
LRRK2 0.87 0.88
SUSD5 0.87 0.87
ZBTB7A 0.85 0.82
MAP3K5 0.85 0.89
TACC1 0.85 0.85
KLF9 0.84 0.87
CBX7 0.84 0.86
KY 0.84 0.83
BCL2L2 0.84 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TUBB2B -0.62 -0.61
BCL7C -0.62 -0.72
KIAA1949 -0.61 -0.53
TRAF4 -0.61 -0.66
RPS19P3 -0.61 -0.79
PPP1R14B -0.61 -0.72
DYNLT1 -0.60 -0.74
PAFAH1B3 -0.60 -0.60
RPS8 -0.60 -0.75
YBX1 -0.60 -0.59

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0008270 zinc ion binding IEA -
GO:0046872 metal ion binding IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217 131 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 136 76 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124/506 870 876 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-129-5p 222 228 m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-130/301 3981 3988 1A,m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-135 440 446 1A hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-138 721 728 1A,m8 hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-141/200a 3367 3373 m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497 815 821 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-153 3950 3956 m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-19 3980 3986 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-205 276 282 m8 hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-214 3618 3624 1A hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-218 1651 1658 1A,m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-219 3570 3577 1A,m8 hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-22 3141 3148 1A,m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU
miR-27 782 788 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-29 3306 3312 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-326 315 322 1A,m8 hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
miR-331 879 885 m8 hsa-miR-331brain GCCCCUGGGCCUAUCCUAGAA
miR-346 136 142 m8 hsa-miR-346brain UGUCUGCCCGCAUGCCUGCCUCU
miR-378 538 544 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU
miR-409-3p 3533 3539 1A hsa-miR-409-3p CGAAUGUUGCUCGGUGAACCCCU
miR-450 222 228 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
miR-505 97 103 m8 hsa-miR-505 GUCAACACUUGCUGGUUUCCUC
miR-539 3601 3607 m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
miR-7 3425 3431 m8 hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG