SZGR2 - Beplay体育中心

Summary?

基因	2308
Symbol	FOXO1
同义词	FKH1\|FKHR\|FOXO1A
描述	forkhead box O1
参考	MIM:136533\|HGNC:HGNC:3819\|Ensembl：ENSG00000150907\|HPRD:00645\|Vega:OTTHUMG00000016775
基因type	protein-coding
地图位置	13Q14.1
Pascal P值	0.871
Sherlock P值	0.314
Fetal beta	-1.167
DMG	1 (# studies)

基因in Data Sources

基因set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
DMG:Montano_2016	Genome-wide DNA methylation analysis	该数据集包括CPG与精神分裂症之间的172个复制关联。	1
DNM:Guipponi_2014	整个外显子组测序分析	49DNMs were identified by comparing the exome of 53 individuals with sporadic SCZ and of their non-affected parents
PMID:cooccur	高通量文献搜索	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	高通量文献搜索	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
网络	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.0217

Section I. Genetics and epigenetics annotation

DNM table

基因	Chromosome	Position	Ref	Alt	Transcript	AA更改	突变类型	筛	CG46	Trait	Study
FOXO1			G	C	NM_002015	第45页	代名词	NA	NA	Schizophrenia	DNM:Guipponi_2014

差异甲基化基因

探测	Chromosome	Position	最近的基因	P (dis)	beta（dis）	FDR (dis)	Study
CG26687842	13	41055491	FOXO1	1.36E-4	0.007	0.136	DMG:Montano_2016

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
ROBO4	0.75	0.80
KIAA1274	0.75	0.77
PCDH12	0.71	0.72
PIK3R6	0.71	0.66
PXN	0.70	0.73
SLC7A5	0.70	0.72
AFAP1L1	0.69	0.71
AL161668.2	0.69	0.72
dag1	0.68	0.71
SLC38A10	0.68	0.68

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
UQCRB	-0.47	-0.56
C5orf53	-0.47	-0.51
USMG5	-0.46	-0.64
ACOT13	-0.45	-0.50
NDUFB9	-0.45	-0.53
Sycp3	-0.44	-0.47
LY96	-0.44	-0.49
GSTO1	-0.44	-0.53
COX7B	-0.44	-0.49
SPHAR	-0.43	-0.52

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
去：0003700	transcription factor activity	IEA		-
GO:0005515	protein binding	新闻学会		11353774\|17202144\|18408765
GO:0016563	转录激活剂活性	艾达		7862145\|10871843\|12228231
GO：0043565	序列特异性DNA结合	艾达		12228231
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001568	血管发育	IEA		-
去：0006355	regulation of transcription, DNA-dependent	IEA		-
去：0006350	transcription	IEA		-
去：0008286	insulin receptor signaling pathway	IEA		-
GO:0006916	anti-apoptosis	艾达		10871843
GO：0042127	调节细胞增殖	IEA		-
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	艾达		10871843\|12228231
细胞分量	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	核	艾达		11311120\|12228231
GO:0005737	cytoplasm	艾达		11311120\|12228231

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \|TFM	androgen receptor	-	HPRD，Biogrid	12482965
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	FOXO1结合p21CIP1启动子的远端区域。这种相互作用是基于未指定物种的FOXO1与来自未指定物种的P21CIP1启动子之间的相互作用进行建模的。	BIND	15084259
CEBPB	C/EBP-beta \|CRP2 \|IL6DBP \|圈\|MGC32080 \|nf-il6 \|TCF5	CCAAT/enhancer binding protein (C/EBP), beta	-	HPRD，Biogrid	11893744
CREBBP	CBP \|kat3a \|RST	CREB binding protein	-	HPRD，Biogrid	10973497
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	beta-catenin interacts with FOXO1. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human FOXO1.	BIND	15905404
ESR1	DKFZP686N23123 \|er \|ESR \|Esra \|时代\|NR3A1	estrogen receptor 1	-	HPRD，Biogrid	11435445
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	FOXO1A interacts with FHL2.	BIND	15692560
FOXG1	BF1 \| BF2 \| FHKL3 \| FKH2 \| FKHL1 \| FKHL2 \| FKHL3 \| FKHL4 \| FOXG1A \| FOXG1B \| FOXG1C \| HBF-1 \| HBF-2 \| HBF-3 \| HBF-G2 \| HBF2 \| HFK1 \| HFK2 \| HFK3 \| KHL2 \| QIN	叉子盒G1	FOXO1与FOXG1相互作用。这种相互作用是基于未指定物种和小鼠FOXG1的FOXO1之间的相互作用建模的。	BIND	15084259
G6PC	G6PT \| GSD1 \| GSD1a \| MGC163350	glucose-6-phosphatase, catalytic subunit	-	HPRD	11672436
HNF4A	FLJ39654 \| HNF4 \| HNF4a7 \| HNF4a8 \| HNF4a9 \| MODY \| MODY1 \| NR2A1 \| NR2A21 \| TCF \| TCF14	hepatocyte nuclear factor 4, alpha	-	HPRD，Biogrid	12519792
HOXA5	HOX1 \|HOX1.3 \|Hox1c \|MGC9376	Homeobox A5	-	HPRD，Biogrid	12163409
SIRT1	sir2l1	Sirtuin（无声交配类型信息法规2同源物）1（S。cerevisiae）	FOXO1A interacts with SIRT1.	BIND	15692560
Smad3	DKFZP586N0721 \|DKFZP686J10186 \|HSPC193 \|HST17436 \|JV15-2 \|madh3 \|MGC60396	SMAD家庭成员3	FOXO1与SMAD3相互作用。这种相互作用是根据未指定物种的FOXO1与未指定物种的SMAD3之间的相互作用进行建模的。	BIND	15084259
Smad3	DKFZP586N0721 \|DKFZP686J10186 \|HSPC193 \|HST17436 \|JV15-2 \|madh3 \|MGC60396	SMAD家庭成员3	-	HPRD，Biogrid	15084259
Smad4	DPC4 \|jip \|madh4	SMAD家庭成员4	FoxO1 interacts with Smad4.	BIND	15084259
Smad4	DPC4 \|jip \|madh4	SMAD家庭成员4	-	HPRD，Biogrid	15084259
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD，Biogrid	10973497
TSC2	FLJ43106 \| LAM \| TSC4	结节硬化2	Affinity Capture-Western 共定位 Reconstituted Complex	BioGRID	17077083
YWHAG	14-3-3-GAMMA	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，伽马多肽	-	HPRD，Biogrid	11237865
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，Zeta多肽	-	HPRD，Biogrid	11237865

Section V. Pathway annotation

Pathway name	Pathway size	＃szgr 2.0基因	Info
KEGG胰岛素信号通路	137	103	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
Biocarta Akt途径	22	16	All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	51	41	All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	37	29	All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY	82	63	All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY	25	20	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID IL6 7途径	47	40	All SZGR 2.0 genes in this pathway
pid pi3kci akt途径	35	30	All SZGR 2.0 genes in this pathway
NGF的Reactome信号传导	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
Reactome发育生物学	396	292	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	38	28	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	44	34	All SZGR 2.0 genes in this pathway
B细胞受体BCR的Reactome下游信号传导事件	97	66	All SZGR 2.0 genes in this pathway
B细胞受体BCR的反应组信号传导	126	90	All SZGR 2.0 genes in this pathway
Reactome NGF信号通过TRKA从质膜发出	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
Reactome PI3K AKT激活	38	29	All SZGR 2.0 genes in this pathway
Reactome GAB1信号体	38	29	All SZGR 2.0 genes in this pathway
β细胞开发的反应组调节	30	23	All SZGR 2.0 genes in this pathway
反应组调节β细胞中基因表达	20	15	All SZGR 2.0 genes in this pathway
PDGF的Reactome信号传导	122	93	All SZGR 2.0 genes in this pathway
Reactome下游信号转导	95	76	All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE	56	39	All SZGR 2.0 genes in this pathway
Reactome的下游信号传导激活的FGFR	100	74	All SZGR 2.0 genes in this pathway
Reactome免疫系统	933	616	All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统	539	350	All SZGR 2.0 genes in this pathway
REACTOME PIP3 ACTIVATES AKT SIGNALING	29	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP	332	228	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
Gary CD5目标DN	431	263	All SZGR 2.0 genes in this pathway
障碍结肠癌复发	42	28	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN	329	219	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
甲状腺癌变性DN	537	339	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP	121	71	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS	290	172	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS	179	105	All SZGR 2.0 genes in this pathway
Haddad T淋巴细胞和NK祖细胞	78	56	All SZGR 2.0 genes in this pathway
Tavor Cebpa靶向DN	30	21	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
皮肤伤口dn的嗜中性粒细胞	225	163	All SZGR 2.0 genes in this pathway
Radmacher AML预后	78	52	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN	246	180	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP	240	152	All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 DN	43	31	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
韦斯顿Vegfa目标	108	71	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
dazard UV响应集群G6	153	112	All SZGR 2.0 genes in this pathway
Wang Smarce1靶向	280	183	All SZGR 2.0 genes in this pathway
韦斯顿·维加法（Weston Vegfa）目标3小时	74	47	All SZGR 2.0 genes in this pathway
Martinez RB1靶向DN	543	317	All SZGR 2.0 genes in this pathway
Martinez TP53目标DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
Iwanaga癌变由Kras Pten DN	353	226	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP	439	257	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
阿隆索转移DN	26	17	All SZGR 2.0 genes in this pathway
ZHOU PANCREATIC BETA CELL	11	9	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS DN	39	20	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C	69	49	All SZGR 2.0 genes in this pathway
Lee早期T淋巴细胞DN	57	36	All SZGR 2.0 genes in this pathway
Yagi AML带有Inv 16易位	422	277	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3	266	180	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN	267	160	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY UP	66	44	All SZGR 2.0 genes in this pathway
中村脂肪形成晚期	104	67	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN	1972年	1213	All SZGR 2.0 genes in this pathway
Lee BMP2目标	745	475	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL	160	106	All SZGR 2.0 genes in this pathway
lim乳腺腔内成熟DN	99	74	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	426	432	1a	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	426	432	1a	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-135	3255	3262	1a,m8	HSA-MIR-135A	Uauggcuuuuuuuuccuauga
miR-135	3255	3262	1a,m8	HSA-MIR-135B	Uauggcuuuucauuccuaugug
miR-139	221	227	1a	hsa-miR-139^脑	UCUACAGUGCACGUGUCU
mir-142-3p	274	280	1a	HSA-MIR-142-3P	uguaguuuccuacuuuaugga
miR-144	424	430	m8	hsa-miR-144	uacaguauagauguauguaguag
miR-145	909	915	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-153	2565	2571	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
mir-182	265	271	1a	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
mir-183	236	242	m8	hsa-miR-183	uauggcacugguagaauucacug
mir-194	832	838	1a	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
mir-27	426	432	m8	hsa-miR-27a^脑	UUCACAGUGGCUAAGUUCCGC
mir-27	426	432	m8	hsa-miR-27b^脑	uucacaguggcuaaguucugc
miR-369-3p	2622	2629	1a,m8	HSA-MIR-369-3P	aauauacaugguugaucuuu
miR-374	2623	2629	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
mir-378*	66	72	1a	HSA-MIR-422B	cuggacuuggagagaaggcc
mir-378*	66	72	1a	HSA-MIR-422A	CUGGACUUAGGGUCAGAAGGCC
miR-381	3248	3254	1a	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-486	658	664	m8	hsa-miR-486	UCCUGUACUGAGCUGCCCCGAG
miR-493-5p	3264	3270	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-493-5p	3264	3270	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-495	689	695	1a	hsa-miR-495^脑	AAACAAACAUGGUGCACUUCUUU
miR-495	689	695	1a	hsa-miR-495^脑	AAACAAACAUGGUGCACUUCUUU
miR-544	290	297	1a,m8	HSA-MIR-544	AUUCUGCAUUUUUAGCAAGU
miR-9	69	75	1a	HSA-MIR-9^SZ	ucuuuguuaucuagcuguauga
mir-96	264	271	1a,m8	HSA-MIR-96^脑	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhere查看与SZ相关的miRNA列表。
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

基因页：FOXO1