Gene Page:PEG10

Summary?
GeneID 23089
Symbol PEG10
Synonyms EDR|HB-1|MEF3L|Mar2|Mart2|RGAG3
Description paternally expressed 10
Reference MIM:609810|HGNC:HGNC:14005|Ensembl:ENSG00000242265|Vega:OTTHUMG00000155578
Gene type protein-coding
Map location 7q21
Pascal p-value 1.316E-4
Sherlock p-value 0.225
Fetal beta 1.018
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07236943 7 94284486 PEG10 -0.026 0.67 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10953143 chr7 94992243 PEG10 23089 0.2 cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),圣2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SRCAP 0.95 0.94
SRRM2 0.94 0.95
ZFYVE26 0.93 0.92
SETD1A 0.93 0.94
PLCG1 0.92 0.92
BAT2 0.92 0.91
DIP2A 0.92 0.92
EP400 0.92 0.93
ZZEF1 0.92 0.92
SPEN 0.92 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.67 -0.73
AF347015.21 -0.65 -0.82
C1orf54 -0.64 -0.81
MT-CO2 -0.64 -0.71
IFI27 -0.63 -0.67
HIGD1B -0.63 -0.72
AF347015.27 -0.62 -0.68
GNG11 -0.62 -0.75
GMFG -0.61 -0.73
VAMP5 -0.61 -0.73

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID MYC ACTIV PATHWAY 79 62 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE UP 152 90 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP 94 57 All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS DN 51 35 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
BILBAN B CLL LPL UP 63 39 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP 112 68 All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 DN 56 32 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP 149 84 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP 194 112 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230 115 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238 135 All SZGR 2.0 genes in this pathway
VETTER TARGETS OF PRKCA AND ETS1 UP 16 8 All SZGR 2.0 genes in this pathway
BEGUM TARGETS OF PAX3 FOXO1 FUSION UP 60 45 All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE UP 28 20 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS DN 103 59 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER A 100 63 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 7Q21 Q22 AMPLICON 76 33 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 DN 38 22 All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO ESTRADIOL UP 37 28 All SZGR 2.0 genes in this pathway
LU IL4 SIGNALING 94 56 All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE DN 52 37 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP 131 87 All SZGR 2.0 genes in this pathway
PETROVA PROX1 TARGETS UP 28 16 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 85 50 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245 144 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 4 48 32 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
BACOLOD RESISTANCE TO ALKYLATING AGENTS UP 26 17 All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246 153 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 109 63 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN PLEURA DN 27 15 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260 174 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE UP 79 40 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G123 UP 45 21 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207 143 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN 74 47 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 DN 17 10 All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES 63 47 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway