SZGR2 - Beplay体育中心

Summary？

基因	2309
象征	FOXO3
Synonyms	AF6q21\|FKHRL1\|FKHRL1P2\|FOXO2\|FOXO3A
Description	叉子盒O3
Reference	MIM：602681\|HGNC：HGNC：3821\|Ensembl：ENSG00000118689\|HPRD:04061\|Vega:OTTHUMG00000015327
基因类型	蛋白质编码
Map location	6q21
Pascal p-value	3.953E-6
Sherlock p-value	0.258
胎儿β	0.569
DMG	1(# studies)
Support	CompositeSet Darnell FMRP目标

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.0078

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG08494708	6	108881870	FOXO3	3.112E-4	-0.175	0.04	DMG：Wockner_2014

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0003700	转录factor activity	IDA		14734530
去：0005515	蛋白质结合	IPI		16809346
GO：0016563	转录activator activity	IDA		10102273
GO：0019901	protein kinase binding	IPI		16751106
GO:0043565	sequence-specific DNA binding	IDA		10102273
生物过程	去学期	证据	神经关键字	PubMed ID
去：0006355	调节转录，DNA依赖性的调节	IEA		-
去：0006350	转录	IEA		-
GO:0006915	凋亡	IDA		10102273
GO：0045648	positive regulation of erythrocyte differentiation	IDA		14734530
GO：0045944	RNA聚合酶II启动子的转录阳性调节	IDA		10102273
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005634	nucleus	IDA		10102273\|16751106
去：0005737	cytoplasm	IDA		10102273\|16751106

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
BCL2L11	bam \|BIM \|bim-alpha6 \|bim-beta6 \|bim-beta7 \|Bod \|Bimel \|Biml	BCL2-like 11 (apoptosis facilitator)	FOXO3A与BCL2L11（BIM）启动子相互作用。	绑定	15688014
CDKN1A	CAP20 \|CDKN1 \|CIP1 \|MDA-6 \|p21 \|SDI1 \|WAF1 \|P21CIP1	细胞周期蛋白依赖性激酶抑制剂1a（P21，CIP1）	FoxO3 binds the distal region of the p21Cip1 promoter.	绑定	15084259
CDKN1B	CDKN4 \|Kip1 \|men1b \|Men4 \|P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	FOXO3A与P27KIP1启动子相互作用。	绑定	15084260
楚克	ikbka \|ikk-alpha \|ikk1 \|ikka \|nfkbika \|TCF16	保守的螺旋环螺旋无处不在激酶	IKK-alpha interacts with and phosphorylates FOXO3a. This interaction was modelled on a demonstrated interaction between IKK-alpha from an unknown species and FOXO3a from human.	绑定	15084260
CTNNB1	ctnnb \|DKFZP686D02253 \|FLJ25606 \|FLJ37923	Catenin（cadherin相关蛋白），β1，88KDA	β-catenin与FOXO3A相互作用。	绑定	15905404
FOXG1	BF1 \| BF2 \| FHKL3 \| FKH2 \| FKHL1 \| FKHL2 \| FKHL3 \| FKHL4 \| FOXG1A \| FOXG1B \| FOXG1C \| HBF-1 \| HBF-2 \| HBF-3 \| HBF-G2 \| HBF2 \| HFK1 \| HFK2 \| HFK3 \| KHL2 \| QIN	forkhead box G1	FoxO3 interacts with FoxG1.	绑定	15084259
ikbkb	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	B细胞，激酶β的Kappa光多肽基因增强子的抑制剂	IKK-beta interacts with and phosphorylates FOXO3a.	绑定	15084260
SIRT1	SIR2L1	Sirtuin（无声交配类型信息法规2同源物）1（S。cerevisiae）	FOXO3interacts with SIRT1.	绑定	14976264
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD家庭成员2	-	HPRD	15084259
SMAD3	DKFZP586N0721 \|DKFZP686J10186 \|HSPC193 \|HST17436 \|JV15-2 \|madh3 \|MGC60396	SMAD家庭成员3	FoxO3 interacts with Smad3.	绑定	15084259
SMAD3	DKFZP586N0721 \|DKFZP686J10186 \|HSPC193 \|HST17436 \|JV15-2 \|madh3 \|MGC60396	SMAD家庭成员3	-	HPRD,BioGRID	15084259
SMAD4	DPC4 \| JIP \| MADH4	SMAD家庭成员4	-	HPRD,BioGRID	15084259
SMAD4	DPC4 \| JIP \| MADH4	SMAD家庭成员4	FoxO3 interacts with Smad4.	绑定	15084259
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	FOXO3A与p53相互作用。	绑定	15604409
YWHAZ	KCIP-1 \|MGC111427 \|MGC126532 \|MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD,BioGRID	10102273

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG趋化因子信号传导途径	190	128	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER	52	45	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
BIOCARTA AKT PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA PTEN PATHWAY	18	14	All SZGR 2.0 genes in this pathway
Biocarta ACH途径	16	13	All SZGR 2.0 genes in this pathway
BIOCARTA LONGEVITY PATHWAY	15	13	All SZGR 2.0 genes in this pathway
SIG PIP3在心脏肌周期中发出信号	67	54	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN B LYMPHOCYTES	36	31	All SZGR 2.0 genes in this pathway
PID SMAD2 3核途径	82	63	All SZGR 2.0 genes in this pathway
PID INSULIN PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID HDAC ClassIII途径	25	20	All SZGR 2.0 genes in this pathway
PID FOXO途径	49	43	All SZGR 2.0 genes in this pathway
PID PI3KCI途径	49	40	All SZGR 2.0 genes in this pathway
PID IL2 PI3K途径	34	27	All SZGR 2.0 genes in this pathway
PID套件途径	52	40	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK途径	36	31	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
SCF套件的Reactome信号传导	78	59	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
淋巴结的反应组信号传导	18	11	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导	109	80	All SZGR 2.0 genes in this pathway
ERBB4信号中的Reactome PI3K事件	38	28	All SZGR 2.0 genes in this pathway
ERBB2信号中的Reactome PI3K事件	44	34	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	97	66	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION	38	29	All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME	38	29	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
Reactome Pi 3K级联	56	39	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统	539	350	All SZGR 2.0 genes in this pathway
Reactome Pip3激活Akt信号传导	29	20	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导	112	80	All SZGR 2.0 genes in this pathway
Zerbini对Sulindac的反应	9	6	All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病	1382	904	All SZGR 2.0 genes in this pathway
hahtola兄弟姐妹Fungoides皮肤	177	113	All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN	485	334	All SZGR 2.0 genes in this pathway
Scheidereit IKK目标	18	15	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
滑落紫外响应SE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3公共DN	483	336	All SZGR 2.0 genes in this pathway
Amundson对砷的回应	217	143	All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向神经上皮	176	111	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP	227	137	All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER	111	69	All SZGR 2.0 genes in this pathway
通过HIF1A DN的缺氧总缺氧	110	78	All SZGR 2.0 genes in this pathway
他靶向DN	7	6	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Shepard粉碎和燃烧突变体	197	110	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP	205	126	All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6	144	98	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病	1691	1088	All SZGR 2.0 genes in this pathway
dazard对UV SCC DN的响应	123	86	All SZGR 2.0 genes in this pathway
布朗感染48小时血巨细胞病毒DN	504	323	All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP	103	69	All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN	51	32	All SZGR 2.0 genes in this pathway
Dazard对UV NHEK DN的反应	318	220	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
MARSON FOXP3目标刺激DN	11	9	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN	258	160	All SZGR 2.0 genes in this pathway
Marzec IL2信号传导DN	36	24	All SZGR 2.0 genes in this pathway
肝癌DN中的阿塞维多甲基化	940	425	All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP	223	132	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP	245	159	All SZGR 2.0 genes in this pathway
格雷希克癌症复制号码	323	240	All SZGR 2.0 genes in this pathway
GU PDEF目标DN	39	20	All SZGR 2.0 genes in this pathway
Chauhan对甲氧基雌二醇DN的反应	102	65	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP	293	203	All SZGR 2.0 genes in this pathway
肌肉DN中的罗马胰岛素靶标	204	114	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1	68	50	All SZGR 2.0 genes in this pathway
Qi缺氧	140	96	All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN	115	73	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向	504	321	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
Smad2或Smad3的Koinuma目标	824	528	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-122	4314	4321	1A，M8	hsa-miR-122a	uggagugugacaaugguuuugu
miR-128	3257	3263	1A	hsa-miR-128a	ucacagugaaccggucuuuu
miR-128	3257	3263	1A	hsa-miR-128b	ucacagugaaccggucuuc
mir-132/212	162	169	1A，M8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
mir-132/212	162	169	1A，M8	HSA-MIR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-153	223	229	1A	HSA-MIR-153	UUGCAUAGUCACAAAAGUGA
miR-182	914	921	1A，M8	HSA-MIR-182	uuuggcaaugguagaacucaca
miR-182	914	921	1A，M8	HSA-MIR-182	uuuggcaaugguagaacucaca
mir-205	4459	4465	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
mir-223	42	49	1A，M8	hsa-miR-223	ugucuuugucaauacccc
miR-27	3257	3264	1A，M8	HSA-MIR-27A^brain	uucacaguggcuaaguuccgc
miR-27	3257	3264	1A，M8	HSA-MIR-27B^brain	UUCACAGUGGCUAAGUUCUGC
miR-29	1312	1318	M8	HSA-MIR-29A^SZ	UAGCACCAUCUGAAAUCGGUU
				HSA-MIR-29B^SZ	UAGCACCAUUUGAAAUCAGUGUU
				HSA-MIR-29C^SZ	uagcaccauuugaaaucggu
mir-30-5p	109	115	1A	HSA-MIR-30A-5P	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	uguaaacauccuaccucucagcu
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
mir-448	223	229	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p	1533	1539	M8	HSA-MIR-493-5p	uuguacaugguaggcuuucauu
miR-495	389	395	M8	HSA-MIR-495^brain	Aaacaaacauggugcacuuuuu
miR-495	389	395	M8	HSA-MIR-495^brain	Aaacaaacauggugcacuuuuu
miR-496	4949	4956	1A，M8	HSA-MIR-496	Auuacauggccaaucuc
miR-542-3p	1789	1795	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
mir-9	3175	3181	M8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
mir-96	915	921	1A	hsa-miR-96^brain	uuuggcacuagcacauuuuugc
mir-96	915	921	1A	hsa-miR-96^brain	uuuggcacuagcacauuuuugc

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:FOXO3