Gene Page:ARHGAP26

概括?
基因 23092
象征 ARHGAP26
Synonyms GRAF|GRAF1|OPHN1L|OPHN1L1
Description Rho GTPase激活蛋白26
Reference MIM:605370|HGNC:HGNC:17073|Ensembl:ENSG00000145819|HPRD：05643|Vega:OTTHUMG00000059705
Gene type protein-coding
Map location 5q31
Pascal p-value 0.603
Sherlock p-value 0.528
Fetal beta -2.212
DMG 1 (# studies)
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV：GWASDB Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed的基因co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.00459
GSMA_IIE 基因组扫描荟萃分析（欧洲官方样品） Psr: 0.01718
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg11796181 5 142422241 ARHGAP26 5.408E-4 0.524 0.048 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7569357 chr2 74778643 ARHGAP26 23092 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005100 Rho GTPase activator activity NAS 10908648
GO:0005096 GTPase activator activity IEA -
GO:0005515 protein binding 新闻学会 11432776
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0007399 神经系统的发展 NAS neurite (GO term level: 5) 9582072
GO:0007165 signal transduction IEA -
GO:0030036 actin cytoskeleton organization NAS 11998687
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005575 cellular_component ND -
GO:0005622 intracellular IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ST INTEGRIN SIGNALING PATHWAY 82 62 该途径中的所有SZGR 2.0基因
PID FAK PATHWAY 59 45 该途径中的所有SZGR 2.0基因
Rho GTPases的Reactome信号传导 113 81 该途径中的所有SZGR 2.0基因
PARENT MTOR SIGNALING UP 567 375 该途径中的所有SZGR 2.0基因
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 该途径中的所有SZGR 2.0基因
HOOI ST7 TARGETS UP 94 57 该途径中的所有SZGR 2.0基因
LIU VMYB TARGETS UP 127 78 该途径中的所有SZGR 2.0基因
DOANE RESPONSE TO ANDROGEN UP 184 125 该途径中的所有SZGR 2.0基因
HORIUCHI WTAP TARGETS UP 306 188 该途径中的所有SZGR 2.0基因
RODRIGUES NTN1 TARGETS DN 158 102 该途径中的所有SZGR 2.0基因
MAYBURD RESPONSE TO L663536 UP 29 18 该途径中的所有SZGR 2.0基因
PEREZ TP63 TARGETS 355 243 该途径中的所有SZGR 2.0基因
MYLLYKANGAS AMPLIFICATION HOT SPOT 27 15 8 该途径中的所有SZGR 2.0基因
EBAUER TARGETS OF PAX3 FOXO1 FUSION DN 48 31 该途径中的所有SZGR 2.0基因
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN 121 79 该途径中的所有SZGR 2.0基因
CUI TCF21 TARGETS 2 DN 830 547 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP 1691年 1088 该途径中的所有SZGR 2.0基因
XU GH1 AUTOCRINE TARGETS UP 268 157 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性3 720 440 该途径中的所有SZGR 2.0基因
riggins他莫昔芬抗性 66 44 该途径中的所有SZGR 2.0基因
FOSTER TOLERANT MACROPHAGE DN 409 268 该途径中的所有SZGR 2.0基因
BRUECKNER TARGETS OF MIRLET7A3 UP 111 69 该途径中的所有SZGR 2.0基因
BREDEMEYER RAG SIGNALING NOT VIA ATM DN 57 34 该途径中的所有SZGR 2.0基因
GRESHOCK CANCER COPY NUMBER UP 323 240 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA D DN 78 34 该途径中的所有SZGR 2.0基因
肌肉DN中的罗马胰岛素靶标 204 114 该途径中的所有SZGR 2.0基因
ZEMBUTSU SENSITIVITY TO MITOMYCIN 19 11 该途径中的所有SZGR 2.0基因
KARLSSON TGFB1 TARGETS UP 127 78 该途径中的所有SZGR 2.0基因
HOELZEL NF1 TARGETS UP 139 93 该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 3 UP 430 288 该途径中的所有SZGR 2.0基因
SERVITJA LIVER HNF1A TARGETS DN 157 105 该途径中的所有SZGR 2.0基因
WANG MLL TARGETS 289 188 该途径中的所有SZGR 2.0基因
DURAND STROMA NS UP 162 103 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 6191 6197 1A HSA-MIR-101 UACAGUACUGUGAUAACUGAAG
HSA-MIR-101 UACAGUACUGUGAUAACUGAAG
miR-144 6190 6197 1A,m8 hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-145 3433 3439 m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-17-5p/20/93.mr/106/519.d 6240 6247 1A,m8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D CAAAGUGCCUCCCUUUAGAGUGU
miR-214 19 25 1A hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-26 1629 1635 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-34/449 1239 1246 1A,m8 HSA-MIR-34Abrain UGGCAGUGUCUUAGCUGGUUGUU
HSA-MIR-34C AGGCAGUGUAGUUAGCUGAUUGC
HSA-MIR-449 uggcaguguauuguagcuggu
HSA-MIR-449b AGGCAGUGUAUUGUUAGCUGGC
mir-377 6204 6210 m8 hsa-miR-377 aucacacaaaggaacuuuuugu
miR-409-5p 705 711 1A hsa-miR-409-5p AGGUUACCCGAGCAACUUUGCA
miR-505 1638 1645 1A,m8 hsa-miR-505 GUCAACACUUGCUGGUUUCCUC