Gene Page:SIPA1L3

Summary?
GeneID 23094
Symbol SIPA1L3
Synonyms CTRCT45|SPAL3|SPAR3
Description signal-induced proliferation-associated 1 like 3
Reference MIM:616655|HGNC:HGNC:23801|Ensembl:ENSG00000105738|HPRD:18755|Vega:OTTHUMG00000073727
Gene type protein-coding
Map location 19q13.13
Pascal p-value 3.149E-4
Sherlock p-value 0.703
Fetal beta -0.638
DMG 1 (# studies)
eGene Myers' cis & trans
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg24420726 19 38684319 SIPA1L3 4.594E-4 0.707 0.046 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
snp_a-2071872 0 SIPA1L3 23094 0.17 trans
rs1146358 chr1 116657767 SIPA1L3 23094 0 trans
rs1934578 chr1 246016476 SIPA1L3 23094 0.09 trans
rs1934577 chr1 246016542 SIPA1L3 23094 0.01 trans
rs17012898 chr2 33601648 SIPA1L3 23094 0.17 trans
rs17012916 chr2 33606031 SIPA1L3 23094 0.11 trans
rs2716734 chr2 39947720 SIPA1L3 23094 2.476E-7 trans
rs2716736 chr2 39947946 SIPA1L3 23094 2.476E-7 trans
rs6543046 chr2 102043302 SIPA1L3 23094 0.12 trans
rs6754175 chr2 135333296 SIPA1L3 23094 0.01 trans
rs7651626 chr3 4133729 SIPA1L3 23094 0.04 trans
rs17039866 chr3 4136543 SIPA1L3 23094 0.01 trans
rs11928084 chr3 4138812 SIPA1L3 23094 5.794E-4 trans
rs9882137 chr3 29494146 SIPA1L3 23094 0.13 trans
rs17052053 chr3 52334592 SIPA1L3 23094 0.1 trans
rs16850133 chr3 140030776 SIPA1L3 23094 2.052E-5 trans
rs7638929 chr3 140031075 SIPA1L3 23094 1.069E-4 trans
rs2597796 chr4 17535859 SIPA1L3 23094 0.05 trans
rs1248551 chr4 46074678 SIPA1L3 23094 0.18 trans
rs17023105 chr4 96074164 SIPA1L3 23094 0.14 trans
rs10516959 chr4 96088848 SIPA1L3 23094 0.14 trans
rs2713946 chr4 111197804 SIPA1L3 23094 0.01 trans
rs16869878 chr5 2523760 SIPA1L3 23094 9.032E-6 trans
rs467856 chr5 3128168 SIPA1L3 23094 8.64E-6 trans
rs16902549 chr5 13407346 SIPA1L3 23094 0.02 trans
rs1010527 chr5 13508264 SIPA1L3 23094 0.11 trans
rs1992711 chr5 13510917 SIPA1L3 23094 0.11 trans
rs6451640 chr5 20088127 SIPA1L3 23094 0.01 trans
snp_a-2169623 0 SIPA1L3 23094 4.063E-6 trans
rs6873234 chr5 169299967 SIPA1L3 23094 3.234E-4 trans
rs7383548 0 SIPA1L3 23094 3.758E-4 trans
rs2016128 chr6 42442743 SIPA1L3 23094 0.2 trans
rs1587434 chr6 66615354 SIPA1L3 23094 3.987E-10 trans
rs4557559 chr6 118406801 SIPA1L3 23094 0 trans
rs6949211 chr7 11231070 SIPA1L3 23094 0.17 trans
rs17154235 chr7 26692981 SIPA1L3 23094 0.07 trans
rs4947631 chr7 50603378 SIPA1L3 23094 1.938E-4 trans
rs10257132 chr7 51422943 SIPA1L3 23094 0.01 trans
rs17155272 chr7 81248809 SIPA1L3 23094 0.15 trans
rs529539 chr7 84003500 SIPA1L3 23094 0.03 trans
rs7796458 chr7 154873701 SIPA1L3 23094 0.11 trans
rs870686 chr8 25253521 SIPA1L3 23094 0.01 trans
rs10503771 chr8 25304019 SIPA1L3 23094 0.02 trans
rs2810511 chr9 136791540 SIPA1L3 23094 0.04 trans
rs10994470 chr10 51558659 SIPA1L3 23094 0.02 trans
rs12767540 chr10 56171628 SIPA1L3 23094 0.15 trans
rs16928875 chr10 73212531 SIPA1L3 23094 0.09 trans
rs12268485 chr10 83608740 SIPA1L3 23094 0.15 trans
rs17106311 chr10 87897271 SIPA1L3 23094 0.19 trans
rs17107175 chr10 88646323 SIPA1L3 23094 0.03 trans
rs1539587 chr10 115372155 SIPA1L3 23094 0.06 trans
rs10768704 chr11 41581241 SIPA1L3 23094 0.15 trans
rs11037691 chr11 43891636 SIPA1L3 23094 0.09 trans
rs4944475 chr11 83985410 SIPA1L3 23094 0.04 trans
rs12270706 chr11 109947508 SIPA1L3 23094 0.02 trans
rs7298298 chr12 17810638 SIPA1L3 23094 0.03 trans
rs11183748 chr12 47516125 SIPA1L3 23094 0.14 trans
rs12423193 chr12 63753383 SIPA1L3 23094 4.845E-4 trans
rs9888446 chr12 63785677 SIPA1L3 23094 3.26E-4 trans
rs1400878 chr12 83609397 SIPA1L3 23094 0 trans
rs16945217 chr12 115679171 SIPA1L3 23094 0.01 trans
rs998923 chr13 35507810 SIPA1L3 23094 4.133E-4 trans
rs2764585 chr13 46880234 SIPA1L3 23094 0.01 trans
rs987104 chr13 61340410 SIPA1L3 23094 0.2 trans
rs9590075 chr13 95414389 SIPA1L3 23094 0.1 trans
snp_a-2222355 0 SIPA1L3 23094 0 trans
rs7176277 chr15 63316182 SIPA1L3 23094 0.05 trans
rs6495316 chr15 78986100 SIPA1L3 23094 0.11 trans
rs1461211 chr15 88628773 SIPA1L3 23094 0.05 trans
rs16972025 chr16 19461881 SIPA1L3 23094 0.03 trans
rs1557515 chr16 19462965 SIPA1L3 23094 0.17 trans
rs4792093 chr17 10939374 SIPA1L3 23094 0.02 trans
rs7223509 chr17 10940048 SIPA1L3 23094 0.02 trans
rs1015663 chr17 14238086 SIPA1L3 23094 0.01 trans
rs295104 chr17 32814665 SIPA1L3 23094 0 trans
rs349973 chr17 50642288 SIPA1L3 23094 0.01 trans
rs8078127 chr17 50761342 SIPA1L3 23094 0 trans
rs10512600 chr17 72812978 SIPA1L3 23094 7.026E-4 trans
rs2661679 chr17 76172103 SIPA1L3 23094 0 trans
rs7217417 chr17 76173174 SIPA1L3 23094 0 trans
rs6040607 chr20 11371092 SIPA1L3 23094 0.06 trans
rs4270401 chr20 61343887 SIPA1L3 23094 2.866的军医 trans
rs225434 chr21 43724740 SIPA1L3 23094 0.02 trans
rs10521889 chrX 149836861 SIPA1L3 23094 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DYRK1A 0.95 0.96
EXOC7 0.95 0.96
ANKRD17 0.94 0.95
FAM161B 0.94 0.96
MBD5 0.94 0.95
TGFBRAP1 0.94 0.96
ZFYVE1 0.94 0.95
YTHDF1 0.94 0.95
N4BP1 0.94 0.95
KIAA1409 0.94 0.94
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.81 -0.86
MT-CO2 -0.80 -0.86
AF347015.21 -0.78 -0.90
AF347015.27 -0.77 -0.82
HIGD1B -0.76 -0.84
AF347015.8 -0.76 -0.84
MT-CYB -0.76 -0.81
FXYD1 -0.76 -0.81
IFI27 -0.76 -0.81
AF347015.33 -0.75 -0.79

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238 144 All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS DN 120 73 All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 100 75 All SZGR 2.0 genes in this pathway
OXFORD RALB TARGETS DN 9 6 All SZGR 2.0 genes in this pathway
FURUKAWA DUSP6 TARGETS PCI35 DN 74 40 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292 168 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3 162 80 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174 100 All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 142 80 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway