基因页：CDK19

Summary？
基因 23097
象征 CDK19
同义词 cdc2l6 | CDK11 | BA346C16.3
Description 依赖细胞周期蛋白的激酶19
Reference MIM：614720|HGNC:HGNC:19338|ENSEMBL：ENSG00000155111|HPRD：07627|Vega：Otthumg0000000015365
基因类型 蛋白质编码
地图位置 6Q21
Pascal P值 0.014
胎儿β 1.291
DMG 1(# studies)

Gene in Data Sources
基因集名称 基因组方法 Description 信息
简历：PGCNP 全基因组协会研究 GWAS
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 1

Section I. Genetics and epigenetics annotation

@差异甲基化基因

探测 染色体 位置 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
CG09435861 6 110968114 CDK19 3.249E-4 0.373 0.04 DMG：Wockner_2014


第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0004693 cyclin-dependent protein kinase activity IEA 神经元（GO期限：8） -
去：0000166 nucleotide binding IEA -
去：0005515 蛋白质结合 IPI 17353931
去：0005524 ATP结合 IEA -
去：0004674 protein serine/threonine kinase activity IEA -
GO：0016740 转移酶活性 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
去：0006468 蛋白氨基酸磷酸化 IEA -
去：0051301 细胞分裂 IEA -
细胞分量 去学期 证据 神经关键字 PubMed ID
去：0005634 nucleus 艾达 18029348

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Reactome发育生物学 396 292 All SZGR 2.0 genes in this pathway
Reactome Ppara激活基因表达 104 72 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
反应组脂肪酸三酰甘油和酮体代谢 168 115 All SZGR 2.0 genes in this pathway
白色脂肪细胞分化的Reactome转录调节 72 53 All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤 783 507 All SZGR 2.0 genes in this pathway
弗雷索莫昔芬反应 51 36 All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 90 65 All SZGR 2.0 genes in this pathway
Basaki YBX1靶向DN 384 230 All SZGR 2.0 genes in this pathway
AKL HTLV1感染DN 68 41 All SZGR 2.0 genes in this pathway
Senese HDAC3靶向DN 536 332 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力 811 508 All SZGR 2.0 genes in this pathway
GC期DN的pasqualucci淋巴瘤 165 104 All SZGR 2.0 genes in this pathway
马纳洛缺氧 207 145 All SZGR 2.0 genes in this pathway
量缺氧 98 71 All SZGR 2.0 genes in this pathway
Bild E2F3致癌特征 246 153 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定 491 310 All SZGR 2.0 genes in this pathway
由FOXP3绑定的Marson刺激 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
由E2F4绑定的Marson未刺激 728 415 All SZGR 2.0 genes in this pathway
Zheng Foxp3目标胸腺 196 137 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存最佳逃亡 246 152 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存次优秀 510 309 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238 145 All SZGR 2.0 genes in this pathway
Boyault肝癌子类G1 UP 113 70 All SZGR 2.0 genes in this pathway
Kobayashi EGFR信号24小时 101 65 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN 1972年 1213 All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN 1080 713 All SZGR 2.0 genes in this pathway
林乳腺干细胞DN 428 246 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-101 1662 1668 1a hsa-miR-101 uacaguacugauaacugaag
miR-125/351 564 570 1a hsa-miR-125bbrain ucccugagacccuaacuuguga
hsa-miR-125abrain ucccugagacccuuaaccugug
mir-130/301 1219 1225 M8 HSA-MIR-130Abrain cagugcaauguaaaaggggau
hsa-miR-301 cagugcaauaugucaaagc
HSA-MIR-130bbrain Cagugcaaugaagggauggau
HSA-MIR-454-3P uagugcaauauugcuuauaggguuu
HSA-MIR-130Abrain cagugcaauguaaaaggggau
hsa-miR-301 cagugcaauaugucaaagc
HSA-MIR-130bbrain Cagugcaaugaagggauggau
HSA-MIR-454-3P uagugcaauauugcuuauaggguuu
mir-132/212 514 520 1a hsa-miR-212SZ uaacagucuccagucacgccc
HSA-MIR-132brain UAACAGUCUACAGCCAUGGUCG
hsa-miR-212SZ uaacagucuccagucacgccc
HSA-MIR-132brain UAACAGUCUACAGCCAUGGUCG
miR-139 1663 1669 M8 HSA-MIR-139brain ucuacagugcacgugucu
miR-144 1661 1668 1A，M8 HSA-MIR-144 uacaguauagauguauguaguag
mir-148/152 1220 1227 1A，M8 HSA-MIR-148A ucagugcacuacaacuuugu
HSA-MIR-152brain UCAGUGCAUGACACUUGGG
HSA-MIR-148B ucagugcaucacacaacuuugu
miR-153 1531 1537 1a HSA-MIR-153 UUGCAUAGUCACAAAAGUGA
mir-18 448 454 M8 HSA-MIR-18A uaagguggaugugcagaua
HSA-MIR-18B UAAGGUGCAUCUAGUGCAGUUA
HSA-MIR-18A uaagguggaugugcagaua
HSA-MIR-18B UAAGGUGCAUCUAGUGCAGUUA
mir-19 1644 1650 M8 HSA-MIR-19A ugugcaaauaugauaugaaaacuga
HSA-MIR-19B UGUGCAAAUCCAUGCAAAACUGA
mir-193 1632 1638 1a HSA-MIR-193A AACUGGCCUACAAAGUCCCAG
HSA-MIR-193B aacuggcccucaaagucccgcuuu
mir-194 515 521 M8 HSA-MIR-194 uguaacagcaacuccauga
mir-205 2083 2089 M8 hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
mir-221/222 771 777 M8 hsa-miR-221brain agcuacauugucugugggggguc
hsa-miR-222brain agcuacaucuggcuacugggucuc
hsa-miR-221brain agcuacauugucugugggggguc
hsa-miR-222brain agcuacaucuggcuacugggucuc
mir-30-5p 2096 2102 M8 HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-369-3p 1156 1162 M8 HSA-MIR-369-3P aauauacaugguugaucuuu
miR-381 1526 1532 1a HSA-MIR-381 uauacaagggcaagcucucugu
mir-410 4198 4204 1a HSA-MIR-410 aauauaacacagauggcugu
mir-433-3p 416 422 1a hsa-miR-433brain aucaugauggggcuccucggugu
mir-448 1530 1537 1A，M8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
mir-539 313 319 1a HSA-MIR-539 GGAGAAAUUAUCCUUGGUGUGU
米尔- 93. - hd / 291 - 3 - p / 294/295/302/372/373/520 264 270 M8 HSA-MIR-93brain aaagugcuguucgugcagguag
hsa-miR-302a uaagugcuugcauguuuguga
hsa-miR-302b uaagugcuuccauguuuaguag
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d Uaagugcuauguugugugu
HSA-MIR-372 aaagugcugcgacauuugagcgu
HSA-MIR-373 Gaagugcuucgauuuggggugu
HSA-MIR-520E Aaagugcuuuuuugaggg
hsa-miR-520a aaagugcuucccuuguggugu
hsa-miR-520b aaagugcuuuuuuagaggg
hsa-miR-520c aaagugcuuuuuuaggggug
hsa-miR-520d aaaguguuugugggguggguu