Gene Page:CUL9

Summary?
GeneID 23113
Symbol CUL9
Synonyms H7AP1|PARC
Description cullin 9
Reference MIM:607489|HGNC:HGNC:15982|Ensembl:ENSG00000112659|HPRD:06317|Vega:OTTHUMG00000014723
Gene type protein-coding
Map location 6p21.1
Pascal p-value 3.244E-5
Sherlock p-value 0.609
Fetal beta -0.577
eGene Caudate basal ganglia
Cortex
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MGA 0.97 0.97
BIRC6 0.97 0.97
C10orf18 0.96 0.96
NSD1 0.96 0.95
UBR5 0.96 0.96
TUG1 0.95 0.96
MED1 0.95 0.96
SBF2 0.95 0.95
ZNF445 0.95 0.94
CLASP1 0.95 0.95
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.71 -0.83
MT-CO2 -0.70 -0.84
IFI27 -0.70 -0.83
FXYD1 -0.70 -0.81
C5orf53 -0.69 -0.72
HIGD1B -0.68 -0.84
AF347015.27 -0.68 -0.79
S100B -0.68 -0.77
AF347015.33 -0.67 -0.78
HLA-F -0.67 -0.70

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 18230339
GO:0005524 ATP binding IEA -
GO:0008270 zinc ion binding IEA -
GO:0031625 ubiquitin protein ligase binding IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006511 ubiquitin-dependent protein catabolic process IEA -
GO:0030071 regulation of mitotic metaphase/anaphase transition IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005680 anaphase-promoting complex IEA -
GO:0005737 cytoplasm IEA -
GO:0031461 cullin-RING ubiquitin ligase complex IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
SCHWAB TARGETS OF BMYB POLYMORPHIC VARIANTS DN 17 12 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 50 24 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 170 97 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 140 81 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 7 UP 118 68 All SZGR 2.0 genes in this pathway