Gene Page:HIC2

概括?
GeneID 23119
Symbol HIC2
同义词 HRG22|ZBTB30|ZNF907
描述 hypermethylated in cancer 2
参考 MIM：607712|HGNC：HGNC：18595|Ensembl:ENSG00000169635|HPRD:07412|Vega:OTTHUMG00000150781
Gene type protein-coding
地图位置 22Q11.21
Pascal p-value 0.789
Sherlock P值 0.297
Fetal beta 2.254
eGene 迈尔斯的顺式和跨性别

数据源中的基因
Gene set name 基因组方法 描述 Info
CNV:YES 拷贝数变异研究 手动策划
GSMA_I 基因组扫描荟萃分析 PSR：0.031

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17495242 chr1 102864446 HIC2 23119 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding NAS 11554746
GO:0008270 zinc ion binding IEA -
GO:0008022 protein C-terminus binding 新闻学会 12052894
GO:0046872 金属离子结合 IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006350 transcription IEA -
GO:0045892 negative regulation of transcription, DNA-dependent NAS 11554746
细胞分量 GO term Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005634 核 IDA 11554746

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177 110 该途径中的所有SZGR 2.0基因
MULLIGHAN MLL SIGNATURE 1 UP 380 236 该途径中的所有SZGR 2.0基因
Mullighan MLL签名2 UP 418 263 该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 2HR DN 88 53 该途径中的所有SZGR 2.0基因
NAGASHIMA NRG1 SIGNALING UP 176 123 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 该途径中的所有SZGR 2.0基因
VANHARANTA UTERINE FIBROID WITH 7Q DELETION UP 67 37 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
PEREZ TP63 TARGETS 355 243 该途径中的所有SZGR 2.0基因
PEREZ TP53 AND TP63 TARGETS 205 145 该途径中的所有SZGR 2.0基因
LUI THYROID CANCER CLUSTER 2 42 31 该途径中的所有SZGR 2.0基因
patil肝癌 747 453 该途径中的所有SZGR 2.0基因
科科拉畸胎瘤 39 25 该途径中的所有SZGR 2.0基因
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 该途径中的所有SZGR 2.0基因
LIAO HAVE SOX4 BINDING SITES 40 26 该途径中的所有SZGR 2.0基因
LIAO METASTASIS 539 324 该途径中的所有SZGR 2.0基因
CHEOK RESPONSE TO HD MTX DN 24 18 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 10HR UP 101 69 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性3 720 440 该途径中的所有SZGR 2.0基因
GRADE COLON AND RECTAL CANCER DN 101 65 该途径中的所有SZGR 2.0基因
BOYAULT LIVER CANCER SUBCLASS G1 UP 113 70 该途径中的所有SZGR 2.0基因
开罗肝母细胞瘤上课 605 377 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 1HR DN 222 147 该途径中的所有SZGR 2.0基因
BAKKER FOXO3 TARGETS DN 187 109 该途径中的所有SZGR 2.0基因
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 该途径中的所有SZGR 2.0基因
IKEDA MIR30 TARGETS UP 116 87 该途径中的所有SZGR 2.0基因
WAKABAYASHI ADIPOGENESIS PPARG BOUND 36HR 29 23 该途径中的所有SZGR 2.0基因
wakabayashi脂肪生成PPARG RXRA绑定8D 882 506 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
let-7/98 4145 4152 1A,m8 HSA-LET-7A脑 UGAGGUAGUAGGUUGUAUAGUU
HSA-LET-7B脑 UGAGGUAGUAGGUUGUGUGGUU
HSA-LET-7C脑 UGAGGUAGUAGGUUGUAUGGUU
HSA-LET-7D脑 agagguaguagguugcauagu
HSA-LET-7E脑 UGAGGUAGGAGGUUGUAUAGU
HSA-LET-7F脑 UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98脑 UGAGGUAGUAAGUUGUAUUGUU
HSA-LET-7GSZ UGAGGUAGUAGUUUGUACAGU
HSA-LET-7I脑 UGAGGUAGUAGUUUGUGCUGU
HSA-LET-7A脑 UGAGGUAGUAGGUUGUAUAGUU
HSA-LET-7B脑 UGAGGUAGUAGGUUGUGUGGUU
HSA-LET-7C脑 UGAGGUAGUAGGUUGUAUGGUU
HSA-LET-7D脑 agagguaguagguugcauagu
HSA-LET-7E脑 UGAGGUAGGAGGUUGUAUAGU
HSA-LET-7F脑 UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98脑 UGAGGUAGUAAGUUGUAUUGUU
HSA-LET-7GSZ UGAGGUAGUAGUUUGUACAGU
HSA-LET-7I脑 UGAGGUAGUAGUUUGUGCUGU
HSA-LET-7A脑 UGAGGUAGUAGGUUGUAUAGUU
HSA-LET-7B脑 UGAGGUAGUAGGUUGUGUGGUU
HSA-LET-7C脑 UGAGGUAGUAGGUUGUAUGGUU
HSA-LET-7D脑 agagguaguagguugcauagu
HSA-LET-7E脑 UGAGGUAGGAGGUUGUAUAGU
HSA-LET-7F脑 UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98脑 UGAGGUAGUAAGUUGUAUUGUU
HSA-LET-7GSZ UGAGGUAGUAGUUUGUACAGU
HSA-LET-7I脑 UGAGGUAGUAGUUUGUGCUGU
HSA-LET-7A脑 UGAGGUAGUAGGUUGUAUAGUU
HSA-LET-7B脑 UGAGGUAGUAGGUUGUGUGGUU
HSA-LET-7C脑 UGAGGUAGUAGGUUGUAUGGUU
HSA-LET-7D脑 agagguaguagguugcauagu
HSA-LET-7E脑 UGAGGUAGGAGGUUGUAUAGU
HSA-LET-7F脑 UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98脑 UGAGGUAGUAAGUUGUAUUGUU
HSA-LET-7GSZ UGAGGUAGUAGUUUGUACAGU
HSA-LET-7I脑 UGAGGUAGUAGUUUGUGCUGU
miR-1/206 4023 4030 1A,m8 hsa-miR-1 Uggaauguaaagaaguaugua
HSA-MIR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-103/107 4190 4197 1A,m8 HSA-MIR-103脑 AGCAGCAUUGUACAGGGCUAUGA
HSA-MIR-107脑 agcagcauuguacgggcuauca
mir-125/351 3800 3807 1A,m8 HSA-MIR-125B脑 UCCCUGAGACCCUAACUUGUGA
HSA-MIR-125A脑 UCCCUGAGACCCUUUAACCUGUG
miR-129-5p 3475 3482 1A,m8 hsa-miR-129脑 CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
hsa-miR-129脑 CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-132/212 4670 4676 1A HSA-MIR-212SZ uaacagucuccagucacgccc
hsa-miR-132脑 uaacagucuacccaugggg
mir-133 3910 3917 1A,m8 hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
mir-134 4105 4111 m8 hsa-miR-134脑 UGUGACUGGUUGACCAGAGGG
mir-135 3541 3547 1A hsa-miR-135a Uauggcuuuuuuuuccuauga
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-141/200a 3331 3337 m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
HSA-MIR-200A UAACACUGUCUGGUAACGAUGU
mir-145 939 946 1A,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
mir-146 2572 2578 m8 hsa-miR-146a UGAGAACUGAAUUCCAUGGGUU
hsa-miR-146b脑 UGAGAACUGAAUUCCAUAGGCU
mir-181 693 700 1A,m8 hsa-miR-181a脑 aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181c脑 aacauucaaccugucggugagu
hsa-miR-181d脑 AACAUUCAUUGUUGUCGGUGGGUU
hsa-miR-181a脑 aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181c脑 aacauucaaccugucggugagu
hsa-miR-181d脑 AACAUUCAUUGUUGUCGGUGGGUU
hsa-miR-181a脑 aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181c脑 aacauucaaccugucggugagu
hsa-miR-181d脑 AACAUUCAUUGUUGUCGGUGGGUU
mir-185 4624 4631 1A,m8 hsa-miR-185脑 Uggagaaaggcaguuc
mir-199 3680 3686 1A hsa-miR-199a cccaguucagacuaccuguuc
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
MiR-200BC/429 3673 3679 m8 HSA-MIR-200B UAAUACUGCCUGGUAAUGAUGAC
HSA-MIR-200C uaauacugccggguaaugaugg
HSA-MIR-429 uaauacuguguguguguguaaaaaccgu
miR-204/211 3907 3913 m8 HSA-MIR-204脑 Uucccuuugucauccuaugccu
HSA-MIR-211 uucccuuugucauccuucgccu
miR-208 4646 4652 1A HSA-MIR-208 AUAAGACGAGCAAAAAGCUUGU
miR-218 2724 2730 m8 HSA-MIR-218脑 uugugcuugaucuaaccaugu
miR-24 2958 2964 m8 HSA-MIR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-299-5p 2717 2723 1A HSA-MIR-299-5P UGGUUUACCGUCCCACAUACAU
miR-30-5p 2792 2799 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
HSA-MIR-30C脑 uguaaacauccuacucucucucucagc
HSA-MIR-30DSZ uguaaacauccccgacuggaag
HSA-MIR-30BSZ UGUAAACAUCCUACACUCAGCU
HSA-MIR-30E-5P uguaaacauccuugacugga
miR-320 147 153 1A HSA-MIR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-324-3p 3360 3366 1A HSA-MIR-324-3P ccacugccccaggugcugcugg
miR-335 1153 1159 1A HSA-MIR-335脑 UCAAGAGCAAUAACGAAAAAUGU
miR-423 3444 3450 m8 HSA-MIR-423 AGCUCGGUCUGAGGCCCCUCAG
miR-450 3475 3481 1A HSA-MIR-450 UUUUUGCGAUGUGUUCCUAAUA
miR-485-5p 1647年 1654年 1A,m8 HSA-MIR-485-5p AGAGGCUGGCCGUGAUGAAUUC
HSA-MIR-485-5p AGAGGCUGGCCGUGAUGAAUUC
mir-490 4340 4346 m8 hsa-miR-490 CAACCUGGAGGACUCCAUGCUG
mir-493-5p 4653 4659 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
mir-499 4645 4652 1A,m8 hsa-miR-499 uuaagacuugcagugauguuaa
miR-539 3378 3385 1A,m8 HSA-MIR-539 ggagaauuauccuuggugugu
miR-543 2600 2606 m8 HSA-MIR-543 AAACAUUCGCGGUGCACUUCU
miR-9 3004 3011 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
mir-93.hd/291-3p/294/295/302/372/373/520 2148 2155 1A,m8 hsa-miR-93脑 AAAGUGCUGUUCGUGCAGGUAG
HSA-MIR-302A UAAGUGCUUCCAUGUUUUGGUGA
HSA-MIR-302B UAAGUGCUUCCAUGUUUUAGUAG
HSA-MIR-302C UAAGUGCUUCCAUGUUUCAGUGG
HSA-MIR-302D UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e AAAGUGCUUCCUUUUUGAGGG
HSA-MIR-520A aaagugcuucccuuguggugu
HSA-MIR-520B AAAGUGCUUCCUUUUAGAGGG
HSA-MIR-520C AAAGUGCUUCCUUUUAGAGGGUU
HSA-MIR-520D AAAGUGCUUCUCUUUGGUGGGUU