Gene Page:SYT11

概括?
基因 23208
象征 SYT11
Synonyms SYT12|sytXI
Description synaptotagmin 11
Reference MIM：608741|HGNC:HGNC:19239|Ensembl:ENSG00000132718|HPRD:12289|Vega:OTTHUMG00000014105
Gene type protein-coding
Map location 1q21.2
Sherlock p-value 0.039
度p-value 度:Sanders_2014:DS1_p=0.155:DS1_beta=0.027900:DS2_p=8.53e-02:DS2_beta=0.086:DS2_FDR=2.70e-01
Fetal beta -1.436
DMG 1 (# studies)

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
度:Sanders_2013 Microarray Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
GSMA_I Genome scan meta-analysis Psr: 0.0235
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00814
Expression Meta-analysis of gene expression Pvalue: 1.455
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25446086 1 155829549 SYT11 9.22E-9 -0.016 4.15e-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005509 钙离子结合 IEA -
GO:0005215 运输er activity IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0006810 运输 IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0008021 synaptic vesicle IEA Synap, Neurotransmitter (GO term level: 12) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
去：0016020 membrane IEA -
GO:0005887 integral to plasma membrane IEA -
GO:0030054 细胞连接 IEA -
GO：0031410 cytoplasmic vesicle IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 该途径中的所有SZGR 2.0基因
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 该途径中的所有SZGR 2.0基因
SENESE HDAC2 TARGETS DN 133 77 该途径中的所有SZGR 2.0基因
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238 135 该途径中的所有SZGR 2.0基因
KOBAYASHI RESPONSE TO ROMIDEPSIN 19 14 该途径中的所有SZGR 2.0基因
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 该途径中的所有SZGR 2.0基因
SHETH LIVER CANCER VS TXNIP LOSS PAM6 46 32 该途径中的所有SZGR 2.0基因
ONDER CDH1 TARGETS 2 UP 256 159 该途径中的所有SZGR 2.0基因
Sasaki成人T细胞白血病 176 122 该途径中的所有SZGR 2.0基因
AFFAR YY1 TARGETS UP 214 133 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 20HR DN 101 70 该途径中的所有SZGR 2.0基因
伊万诺娃造血干细胞 254 164 该途径中的所有SZGR 2.0基因
伊万诺娃造血干细胞AND PROGENITOR 681 420 该途径中的所有SZGR 2.0基因
LEIN OLIGODENDROCYTE MARKERS 74 53 该途径中的所有SZGR 2.0基因
GAVIN FOXP3 TARGETS CLUSTER T4 94 69 该途径中的所有SZGR 2.0基因
Gavin Foxp3目标集群P4 100 62 该途径中的所有SZGR 2.0基因
GAVIN PDE3B TARGETS 22 15 该途径中的所有SZGR 2.0基因
HELLER SILENCED BY METHYLATION DN 105 67 该途径中的所有SZGR 2.0基因
HELLER HDAC TARGETS UP 317 208 该途径中的所有SZGR 2.0基因
Heller HDAC靶向被甲基化的沉默 461 298 该途径中的所有SZGR 2.0基因
WALLACE PROSTATE CANCER RACE UP 299 167 该途径中的所有SZGR 2.0基因
CHUNG BLISTER CYTOTOXICITY UP 134 84 该途径中的所有SZGR 2.0基因
FIRESTEIN CTNNB1 PATHWAY 33 23 该途径中的所有SZGR 2.0基因
Sengupta EBNA1反相关 173 85 该途径中的所有SZGR 2.0基因
KARLSSON TGFB1 TARGETS DN 207 139 该途径中的所有SZGR 2.0基因
金所有障碍少突细胞数量ORR UP 756 494 该途径中的所有SZGR 2.0基因
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 该途径中的所有SZGR 2.0基因
KIM ALL DISORDERS CALB1 CORR UP 548 370 该途径中的所有SZGR 2.0基因
GREGORY SYNTHETIC LETHAL WITH IMATINIB 145 83 该途径中的所有SZGR 2.0基因
PASINI SUZ12 TARGETS DN 315 215 该途径中的所有SZGR 2.0基因
FEVR CTNNB1 TARGETS DN 553 343 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因
LE NEURONAL DIFFERENTIATION UP 18 13 该途径中的所有SZGR 2.0基因
Plasari TGFB1目标10小时DN 244 157 该途径中的所有SZGR 2.0基因
GUILLAUMOND KLF10 TARGETS UP 51 39 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 2950 2957 1A,m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain agagguaguagguugcauagu
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-124.1 2617 2623 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-186 3473 3479 1A hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-19 3117 3124 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga