Gene Page:SIK2

Summary?
GeneID 23235
Symbol SIK2
Synonyms LOH11CR1I|QIK|SIK-2|SNF1LK2
Description salt inducible kinase 2
Reference MIM:608973|HGNC:HGNC:21680|HPRD:12348|
Gene type protein-coding
Map location 11q23.1
Pascal p-value 0.982
DMG 1 (# studies)
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21419428 11 111473938 SIK2 1.14E-8 -0.011 4.8E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TCTEX1D2 0.80 0.87
NDUFS4 0.80 0.83
NDUFAF2 0.80 0.82
TXN 0.78 0.75
GTF2A2 0.78 0.82
ATP5E 0.78 0.74
CHCHD1 0.78 0.81
TXNDC17 0.77 0.79
ARL16 0.77 0.77
SNRPD2 0.77 0.77
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.15 -0.56 -0.66
AF347015.26 -0.55 -0.67
EPAS1 -0.55 -0.68
MMRN2 -0.54 -0.57
AF347015.2 -0.54 -0.64
AF347015.8 -0.53 -0.62
MT-CYB -0.53 -0.62
TGM2 -0.53 -0.62
PRELP -0.53 -0.65
HLA-E -0.53 -0.65

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IDA 14976552
GO:0005515 protein binding IEA -
GO:0005524 ATP binding IDA 14976552
GO:0004674 protein serine/threonine kinase activity IDA 14976552
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006468 protein amino acid phosphorylation IDA 14976552
GO:0007243 protein kinase cascade IDA 14976552
GO:0046626 regulation of insulin receptor signaling pathway ISS -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005737 cytoplasm ISS -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID LKB1 PATHWAY 47 37 All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391 222 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
KANG GIST WITH PDGFRA UP 50 27 All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183 115 All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 171 96 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 2686 2692 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-103/107 1532 1539 1A,m8 hsa-miR-103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-124/506 1038 1044 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-137 1211 1217 1A hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-142-3p 2682 2688 m8 hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
miR-144 2686 2692 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-145 126 133 1A,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-218 1508 1515 1A,m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-329 2676 2682 1A hsa-miR-329brain AACACACCUGGUUAACCUCUUU