Gene Page:PLCB1
Summary？
| 基因 | 23236 |
| 象征 | PLCB1 |
| Synonyms | EIEE12 | PI-PLC | PLC-154 | PLC-I | PLC-BETA-1 | PLC154 | PLCB1A | PLCB1B |
| Description | phospholipase C beta 1 |
| Reference | MIM:607120|HGNC：HGNC：15917|ENSEMBL：ENSG00000182621|HPRD:06177|Vega：Otthumg0000000031849 |
| 基因类型 | 蛋白质编码 |
| Map location | 20p12 |
| pascal p-value | 0.185 |
| Sherlock p-value | 0.014 |
| 胎儿β | -1.866 |
| DMG | 2(# studies) |
| 主持人 | Myers' cis & trans |
| Support | CANABINOID 细胞内信号转导 METABOTROPIC GLUTAMATE RECEPTOR 5-羟色胺 G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS G2Cdb.human_mGluR5 G2CDB.HUMANNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP目标 Ascano FMRP targets 潜在的突触基因 |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| 简历：Phewas | phenome-wide association studies (PheWAS) | 157 SNPs associated with schizophrenia | 1 |
| DMG：JAFFE_2016 | 全基因组DNA甲基化分析 | 该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。 | 2 |
| DMG：Nishioka_2013 | 全基因组DNA甲基化分析 | 作者研究了来自18例第一期精神分裂症（FESZ）和15个正常对照的18例外周血细胞中DNA的甲基化谱。 | 2 |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| GSMA_I | Genome scan meta-analysis | psr: 0.046 | |
| Literature | High-throughput literature-search | 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症 | 点击显示详细信息 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | PPI网络中最短路径的贡献：0.3045 |
Section I. Genetics and epigenetics annotation
简历：Phewas
简历：Phewas| SNP ID | 染色体 | 位置 | Allele | p | 功能 | Gene | 向上/向下距离 |
|---|---|---|---|---|---|---|---|
| RS6056209 | 20. | 8836771 | 无效的 | 0.6712 | PLCB1 | 无效的 |
Differentially methylated gene
| probe | 染色体 | 位置 | Nearest gene | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| CG23657409 | 20. | 8112754 | PLCB1 | -0.023 | 0.52 | DMG：Nishioka_2013 | |
| CG23657409 | 20. | 8112754 | PLCB1 | 9.7E-8 | -0.012 | 2.16e-5 | DMG：JAFFE_2016 |
eQTL annotation
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS6056552 | CHR20 | 9309712 | PLCB1 | 23236 | 0.07 | 顺式 |
第二节。转录组注释
一般基因表达（GTEX）
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| 前10个积极共表达的基因 | ||
| Gene | pearson's Correlation | 斯皮尔曼的相关性 |
| pRPF6 | 0.97 | 0.97 |
| ppm1g | 0.95 | 0.96 |
| CYTH2 | 0.94 | 0.94 |
| ZNF821 | 0.94 | 0.95 |
| IP6K2 | 0.94 | 0.93 |
| RBM4 | 0.94 | 0.96 |
| pRPF31 | 0.93 | 0.94 |
| ZNF259 | 0.93 | 0.94 |
| ewsr1 | 0.93 | 0.94 |
| Smarcb1 | 0.93 | 0.94 |
| Top 10 negatively co-expressed genes | ||
| Gene | pearson's Correlation | 斯皮尔曼的相关性 |
| AF347015.31 | -0.80 | -0.89 |
| MT-CO2 | -0.79 | -0.89 |
| AF347015.33 | -0.79 | -0.89 |
| AF347015.27 | -0.78 | -0.89 |
| mt-cyb | -0.77 | -0.87 |
| AF347015.8 | -0.76 | -0.88 |
| FXYD1 | -0.75 | -0.87 |
| HLA-F | -0.75 | -0.80 |
| C5orf53 | -0.75 | -0.76 |
| S100B | -0.74 | -0.83 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| GO:0004871 | 信号传感器活性 | IEA | - | |
| 去：0005509 | calcium ion binding | IEA | - | |
| 去：0004435 | phosphoinositide phospholipase C activity | nas | 11118617 | |
| GO：0016787 | 水解酶活性 | IEA | - | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO：0016042 | lipid catabolic process | IEA | - | |
| GO:0007242 | 细胞内信号传导级联 | IEA | - | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005634 | nucleus | nas | 10760467 | |
| 去：0005737 | cytoplasm | IDA | 11118617 | |
| 去：0005886 | plasma membrane | 经验 | 2841328|9198220 |
Section V. Pathway annotation
第六节。microRNA注释
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| miR-124/506 | 2464 | 2470 | M8 | hsa-miR-506 | UAAGGCACCCUUCUGAGUAGA |
| HSA-MIR-124brain | UAAGGCACGCGGUGAAUGCC | ||||
| miR-125/351 | 1124 | 1130 | 1a | hsa-miR-125bbrain | ucccugagacccuaacuuguga |
| hsa-miR-125abrain | ucccugagacccuuaaccugug | ||||
| mir-130/301 | 1999 | 2005 | M8 | hsa-miR-130abrain | cagugcaauguaaaaggggau |
| hsa-miR-301 | cagugcaauaugucaaagc | ||||
| hsa-miR-130bbrain | Cagugcaaugaagggauggau | ||||
| hsa-miR-454-3p | UAGUGCAAUAUUGCUUAUAGGGUUU | ||||
| miR-137 | 1770 | 1777 | 1A，M8 | HSA-MIR-137 | uauugcuuaagaauacgcguag |
| HSA-MIR-137 | uauugcuuaagaauacgcguag | ||||
| miR-153 | 2958 | 2965 | 1A，M8 | HSA-MIR-153 | UUGCAUAGUCACAAAAGUGA |
| miR-17-5p/20/93.mr/106/519.d | 2001 | 2007 | M8 | hsa-miR-17-5p | caaagugcuuacugcagguagu |
| hsa-miR-20abrain | UAAAGUGCUUAUAGUGCAGGUAG | ||||
| hsa-miR-106a | AAAAGUGCUUACAGUGCAGGUAGC | ||||
| hsa-miR-106bSZ | UAAAGUGCUGACAGUGCAGAU | ||||
| hsa-miR-20bSZ | CAAAGUGCUCAUAGUGCAGGUAG | ||||
| HSA-MIR-519D | caaagugccucccuuuagugugu | ||||
| miR-19 | 1998 | 2004 | M8 | HSA-MIR-19A | UGUGCAAAUCUAUGCAAAACUGA |
| HSA-MIR-19B | UGUGCAAAUCCAUGCAAAACUGA | ||||
| mir-205 | 1808 | 1814 | M8 | hsa-miR-205 | UCCUUCAUUCCACCGGAGUCUG |
| hsa-miR-205 | UCCUUCAUUCCACCGGAGUCUG | ||||
| miR-26 | 2412 | 2419 | 1A，M8 | HSA-MIR-26Abrain | UUCAAGUAAUCCAGGAUAGGC |
| HSA-MIR-26BSZ | UUCAAGUAAUUCAGGAUAGGUU | ||||
| mir-328 | 2751 | 2757 | M8 | hsa-miR-328brain | cuggcccucugccuuccgu |
| mir-330 | 503 | 509 | M8 | hsa-miR-330brain | GCAAAGCACACGGCCUGCAGAGA |
| miR-34/449 | 72 | 78 | M8 | hsa-miR-34abrain | uggcaguguuaguguguuuu |
| hsa-miR-34c | Aggcaguguaguagcugauugc | ||||
| hsa-miR-449 | UGGCAGUGUAUUGUUAGCUGGU | ||||
| HSA-MIR-449B | AGGCAGUGUAUUGUUAGCUGGC | ||||
| miR-377 | 2498 | 2505 | 1A，M8 | HSA-MIR-377 | aucacacaaaggaacuuuuugu |
| mir-448 | 2959 | 2965 | 1a | hsa-miR-448 | UUGCAUAUGUAGGAUGUCCCAU |
| mir-7 | 2983 | 2989 | 1a | hsa-miR-7SZ | UGGAAGACUAGUGAUUUUGUUG |
| hsa-miR-7SZ | UGGAAGACUAGUGAUUUUGUUG | ||||