基因页：弧

概括?
GeneID 23237
Symbol 弧
同义词 arg3.1
描述 活性调节的细胞骨架相关蛋白
参考 MIM:612461|HGNC：HGNC：648|Ensembl:ENSG00000198576|HPRD：12469|Vega：Otthumg00000134310
Gene type protein-coding
地图位置 8Q24.3
Pascal P值 1.634E-5
Fetal beta -1.837
eGene 迈尔斯的顺式和跨性别
支持 G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanNRC
g2cdb.humanpsd
G2CDB.HUMANPSP
Potential synaptic genes

数据源中的基因
Gene set name 基因组方法 描述 Info
CV:GWAScat 全基因组关联研究 This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV：GWASDB 全基因组关联研究 gwasdbrecords for schizophrenia
简历：PGCNP 全基因组协会研究 GWAS
PMID:cooccur 高通量文献搜索 Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 高通量文献搜索 Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias Click to show details
go_annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

第一节遗传学和表观遗传学注释

@EQTL注释

SNP ID Chromosome Position eGene Gene Entrez ID PVALUE qvalue TSS distance eQTL type
RS4976941 chr8 142744439 弧 23237 0 cis
rs17126801 chr1 65098162 弧 23237 0.01 trans
RS2566762 chr1 68582456 弧 23237 0.11 trans
rs17100231 chr1 77761339 弧 23237 0.01 trans
rs17100274 chr1 77774412 弧 23237 9.021E-6 trans
rs17029293 chr1 112567844 弧 23237 0.01 trans
RS17649760 chr1 150425940 弧 23237 0.2 trans
rs6666937 chr1 170286842 弧 23237 8.802E-9 trans
rs16843112 chr1 198420657 弧 23237 2.309E-4 trans
rs697455 chr1 202512075 弧 23237 0 trans
rs6673109 chr1 207253132 弧 23237 0.1 trans
rs17260245 chr1 209411024 弧 23237 0.16 trans
rs1796829 chr1 239661818 弧 23237 0.16 trans
rs12034521 chr1 239717679 弧 23237 0.02 trans
snp_a-1990354 0 弧 23237 0.01 trans
rs6432434 chr2 14160930 弧 23237 0.19 trans
RS12611832 chr2 31196248 弧 23237 0.11 trans
RS12614732 chr2 31199913 弧 23237 0.11 trans
RS12465555 chr2 44118188 弧 23237 0 trans
RS17029079 chr2 64736071 弧 23237 0.03 trans
rs17038084 chr2 85192280 弧 23237 0.05 trans
rs17024035 chr2 100968559 弧 23237 2.196E-5 trans
RS1437972 chr2 100987386 弧 23237 0.06 trans
RS7574684 chr2 100992911 弧 23237 2.196E-5 trans
RS17024129 chr2 100995144 弧 23237 2.196E-5 trans
RS17024136 chr2 100995382 弧 23237 9.615E-4 trans
rs7585898 chr2 100998292 弧 23237 2.196E-5 trans
RS6716367 chr2 101000013 弧 23237 6.592E-4 trans
RS1370627 chr2 101009384 弧 23237 2.196E-5 trans
RS4149509 chr2 101023698 弧 23237 0.04 trans
RS6707117 chr2 136855504 弧 23237 4.034E-5 trans
RS16838911 chr2 156087569 弧 23237 5.464e-6 trans
rs9807949 chr2 182655005 弧 23237 0.04 trans
rs7608942 chr2 182820100 弧 23237 2.039E-7 trans
RS17684934 chr3 4443547 弧 23237 0.08 trans
RS17040633 chr3 4446836 弧 23237 0.08 trans
RS17756483 chr3 4451309 弧 23237 0.08 trans
rs17685441 chr3 4465165 弧 23237 0.08 trans
RS6772815 chr3 5164768 弧 23237 0.03 trans
rs997245 chr3 61844600 弧 23237 0.01 trans
RS1524966 chr3 65530832 弧 23237 0.16 trans
RS6549584 chr3 74146787 弧 23237 0.14 trans
RS1381835 chr3 110600595 弧 23237 0.19 trans
rs6807632 chr3 111395567 弧 23237 0 trans
RS16839796 chr4 7188348 弧 23237 0.02 trans
rs17005000 chr4 81826551 弧 23237 0.05 trans
rs10011751 chr4 93984994 弧 23237 0.14 trans
rs6881821 chr5 8578465 弧 23237 0.03 trans
RS679416 chr5 10310796 弧 23237 0.15 trans
rs2115110 chr5 38193428 弧 23237 0.02 trans
RS10040715 chr5 57594207 弧 23237 2.784e-4 trans
rs13189446 chr5 61572988 弧 23237 0.04 trans
rs16890628 chr5 61612280 弧 23237 0.06 trans
rs16890651 chr5 61629538 弧 23237 0.05 trans
rs153864 chr5 61720941 弧 23237 0.1 trans
rs153869 chr5 61754994 弧 23237 0.07 trans
rs40290 chr5 61817141 弧 23237 0.06 trans
RS32178 chr5 61828146 弧 23237 0.09 trans
RS32170 chr5 61847072 弧 23237 0.07 trans
RS32053 chr5 61877627 弧 23237 0.17 trans
SNP_A-4217300 0 弧 23237 0.03 trans
rs17134275 chr5 100634998 弧 23237 0.07 trans
RS2963232 chr5 103713882 弧 23237 0.16 trans
rs2900115 chr5 117414349 弧 23237 0.13 trans
RS2141482 chr5 136760477 弧 23237 1.634E-6 trans
rs2189803 chr5 137684661 弧 23237 1.135E-4 trans
RS17209139 chr5 142552525 弧 23237 0 trans
rs259913 chr5 169370782 弧 23237 0.05 trans
RS2116811 chr5 171820051 弧 23237 0.11 trans
rs1977059 chr6 5720825 弧 23237 0.19 trans
rs2239516 chr6 30578047 弧 23237 0.11 trans
RS6904236 chr6 30596134 弧 23237 0.05 trans
rs2030024 chr6 131014624 弧 23237 0 trans
RS10485094 chr6 131071433 弧 23237 8.114E-4 trans
RS17059517 chr6 131076254 弧 23237 0 trans
RS9402280 chr6 131102770 弧 23237 0.01 trans
RS12176346 chr6 136732663 弧 23237 0.1 trans
rs2237264 chr6 136919977 弧 23237 0.1 trans
rs12164028 chr6 136929934 弧 23237 9.036e-5 trans
rs17080121 chr6 151009189 弧 23237 0.1 trans
rs10945911 chr6 164047509 弧 23237 0.18 trans
RS12701006 chr7 30147298 弧 23237 6.635E-4 trans
rs1419793 chr7 34697630 弧 23237 8.184E-5 trans
rs17621151 chr7 53572911 弧 23237 0.02 trans
RS17141666 chr7 69928490 弧 23237 0.01 trans
rs6978484 chr7 69979339 弧 23237 0.03 trans
RS17141735 chr7 70005608 弧 23237 0.07 trans
RS17141754 chr7 70033812 弧 23237 0.09 trans
rs12671672 chr7 117614219 弧 23237 0.15 trans
RS3993439 chr7 128679933 弧 23237 0.01 trans
rs6958821 chr7 153253566 弧 23237 0.01 trans
rs7829733 chr8 9691720 弧 23237 0.03 trans
rs10102886 chr8 51805574 弧 23237 0 trans
RS1457044 chr8 59257567 弧 23237 0.01 trans
RS1457032 chr8 59290536 弧 23237 0.09 trans
RS2217103 chr8 69974000 弧 23237 0.11 trans
RS1733950 chr8 90062516 弧 23237 0 trans
rs318307 chr8 90185459 弧 23237 0.15 trans
RS10282827 chr8 138034102 弧 23237 0.18 trans
RS4976941 chr8 142744439 弧 23237 0.11 trans
rs9298651 chr9 10076275 弧 23237 0.02 trans
rs16931013 chr9 10076859 弧 23237 0.02 trans
rs16931018 chr9 10077048 弧 23237 0.02 trans
rs1467547 chr9 17630726 弧 23237 0.1 trans
rs1335159 chr9 31147839 弧 23237 0.05 trans
rs1109460 chr9 79410224 弧 23237 0.01 trans
RS11791891 chr9 87512411 弧 23237 7.896E-4 trans
RS17087884 chr9 87548646 弧 23237 0.11 trans
RS3780642 chr9 87553144 弧 23237 1.263E-7 trans
RS3780645 chr9 87559793 弧 23237 0.16 trans
RS4877892 chr9 87560460 弧 23237 0.11 trans
RS10992752 chr9 96240578 弧 23237 0.16 trans
RS10981864 chr9 116416735 弧 23237 0.12 trans
RS2807706 chr9 121744331 弧 23237 0.02 trans
rs2818297 chr9 121757015 弧 23237 0.09 trans
RS10739527 chr9 121772512 弧 23237 0.04 trans
RS10760278 chr9 126094457 弧 23237 0.1 trans
rs2417062 chr9 130715921 弧 23237 0.04 trans
RS12005879 chr9 133737648 弧 23237 0.08 trans
RS11252514 Chr10 499572 弧 23237 0.18 trans
rs4745717 Chr10 75305784 弧 23237 0.01 trans
rs4750827 Chr10 132547183 弧 23237 0.1 trans
RS4750829 Chr10 132547260 弧 23237 0.1 trans
rs11021918 Chr11 2269189 弧 23237 0.19 trans
rs10741552 Chr11 11539873 弧 23237 0.17 trans
rs769442 Chr11 64888954 弧 23237 0.01 trans
rs1255149 Chr11 95484493 弧 23237 0.18 trans
RS3748251 Chr11 95519156 弧 23237 0.04 trans
rs16922543 Chr11 95526116 弧 23237 0.04 trans
RS16922622 Chr11 95567387 弧 23237 0.04 trans
RS3181323 Chr11 104878386 弧 23237 0.08 trans
RS6590743 Chr11 134405995 弧 23237 0.16 trans
RS2239031 CHR12 2336168 弧 23237 0.05 trans
rs2109556 CHR12 3887300 弧 23237 0.2 trans
rs374484 CHR12 27627159 弧 23237 0.12 trans
rs2407183 CHR12 43399127 弧 23237 0.17 trans
rs8490 CHR12 51453904 弧 23237 0 trans
RS17113079 CHR12 74538548 弧 23237 0 trans
RS17113131 CHR12 74564573 弧 23237 0 trans
rs7296098 CHR12 113228993 弧 23237 0.01 trans
RS11833075 CHR12 122114592 弧 23237 0.01 trans
rs3803214 CHR13 25740255 弧 23237 0.04 trans
snp_a-4201259 0 弧 23237 0.12 trans
RS4497566 CHR13 51694324 弧 23237 0 trans
rs17088392 CHR13 72257235 弧 23237 0.08 trans
RS9574766 CHR13 81723606 弧 23237 0.08 trans
rs7327697 CHR13 83227456 弧 23237 0.19 trans
RS7322001 CHR13 94895345 弧 23237 0.08 trans
snp_a-1952108 0 弧 23237 0.16 trans
rs7156088 CHR14 27821865 弧 23237 0.14 trans
RS11846180 CHR14 51377031 弧 23237 0.01 trans
rs8022005 CHR14 61345380 弧 23237 0.11 trans
rs7161226 CHR14 88327803 弧 23237 0.02 trans
rs1885073 CHR14 104357181 弧 23237 1.279E-4 trans
rs4465541 CHR14 105016846 弧 23237 0.02 trans
rs17761129 CHR15 24262387 弧 23237 0.11 trans
rs4777108 CHR15 69383464 弧 23237 0.13 trans
rs11858762 CHR15 81386594 弧 23237 0.06 trans
rs9635390 CHR15 90809632 弧 23237 0.03 trans
rs8047151 CHR16 17209696 弧 23237 1.986E-9 trans
rs4271578 CHR16 17213886 弧 23237 4.518E-8 trans
rs7200513 CHR16 17219474 弧 23237 4.144e-9 trans
RS3829495 CHR16 17221986 弧 23237 4.512E-12 trans
RS7193763 CHR16 17225534 弧 23237 3.618e-7 trans
rs4316748 CHR16 55781757 弧 23237 5.773E-4 trans
RS1867231 CHR17 13678834 弧 23237 0.05 trans
rs7219986 CHR17 53263206 弧 23237 0.17 trans
rs17817797 CHR17 53332496 弧 23237 0.04 trans
RS9646596 CHR18 53049211 弧 23237 0.03 trans
rs17594526 CHR18 53058237 弧 23237 0.04 trans
rs11152369 CHR18 53066327 弧 23237 0.12 trans
RS1469488 CHR18 57228449 弧 23237 0.09 trans
RS1469489 CHR18 57228488 弧 23237 0.02 trans
rs9319807 CHR18 68766779 弧 23237 9.702E-4 trans
snp_a-1821751 0 弧 23237 2.063E-4 trans
rs1942464 CHR18 70509877 弧 23237 0.11 trans
rs17056922 CHR18 73086804 弧 23237 0.11 trans
snp_a-2138575 0 弧 23237 0.09 trans
RS10853720 CHR19 39265797 弧 23237 0.09 trans
RS6417634 CHR20 6408617 弧 23237 0.02 trans
rs6026122 CHR20 56769083 弧 23237 0.08 trans
rs134028 CHR22 28048448 弧 23237 0.01 trans
rs5768165 CHR22 48318197 弧 23237 0.17 trans
rs5768168 CHR22 48319334 弧 23237 0.17 trans
RS5768173 CHR22 48321475 弧 23237 0.17 trans
RS16978981 chrX 13538144 弧 23237 0.01 trans
rs7879159 chrX 19481591 弧 23237 0.07 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

无法使用

Devlopment期间的基因表达（BrainCloud）

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因


Section III. Gene Ontology annotation

Biological process GO term Evidence Neuro keywords PubMed ID
GO:0009952 前/后模式形成 IEA -
GO:0007492 endoderm development IEA -
GO:0006897 endocytosis IEA -
去：0007275 多细胞生物发育 IEA -
细胞分量 GO term Evidence Neuro keywords PubMed ID
GO:0042995 细胞投影 IEA axon (GO term level: 4) -
GO：0045211 突触后膜 IEA Synap, Neurotransmitter (GO term level: 5) -
GO：0045202 synapse IEA 神经元，突触，神经递质，神经胶质（GO期限：2） -
去：0001669 acrosome IEA -
GO:0005856 cytoskeleton IEA -
GO:0005737 细胞质 IEA -
GO:0005768 内体 IEA -
GO:0005886 质膜 IEA -
GO：0030054 细胞连接 IEA -

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
NAGASHIMA NRG1 SIGNALING UP 176 123 该途径中的所有SZGR 2.0基因
NAGASHIMA EGF SIGNALING UP 58 40 该途径中的所有SZGR 2.0基因
Kim WT1靶向 214 155 该途径中的所有SZGR 2.0基因
KIM WT1 TARGETS 8HR UP 164 122 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK 1652 1023 该途径中的所有SZGR 2.0基因
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 116 79 该途径中的所有SZGR 2.0基因
Schaeffer前列腺开发48小时 487 286 该途径中的所有SZGR 2.0基因
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON 157 87 该途径中的所有SZGR 2.0基因
NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER 94 60 该途径中的所有SZGR 2.0基因
Shipp DLBCL治愈与致命 39 22 该途径中的所有SZGR 2.0基因
TAVOR CEBPA TARGETS UP 48 36 该途径中的所有SZGR 2.0基因
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER 49 30 该途径中的所有SZGR 2.0基因
Mitsiades对aplidin的反应 439 257 该途径中的所有SZGR 2.0基因
LIN NPAS4靶向DN 68 48 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 491 319 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 该途径中的所有SZGR 2.0基因
DALESSIO TSA RESPONSE 29 16 该途径中的所有SZGR 2.0基因
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR 152 88 该途径中的所有SZGR 2.0基因
PLASARI TGFB1 TARGETS 10HR UP 199 143 该途径中的所有SZGR 2.0基因
PLASARI TGFB1 SIGNALING VIA NFIC 10HR UP 54 38 该途径中的所有SZGR 2.0基因
前列腺癌模型中的Acevedo FGFR1靶标 289 184 该途径中的所有SZGR 2.0基因
林乳腺干细胞向上 489 314 该途径中的所有SZGR 2.0基因
Durand Stroma S向上 297 194 该途径中的所有SZGR 2.0基因

第六节。microRNA注释

miRNA family 目标位置 mirna id miRNA seq
UTR start UTR end Match method
mir-149 722 728 m8 hsa-miR-149脑 UCUGGCUCCGUGUCUUCACUCC
mir-19 1338 1345 1a,m8 hsa-miR-19a ugugcaaauaugauaugaaaacuga
hsa-miR-19b ugugcaaauccaugcaaaacuga
mir-495 1527年 1533年 1a hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU