Gene Page:RPRD2

Summary?
GeneID 23248
Symbol RPRD2
Synonyms HSPC099|KIAA0460
Description regulation of nuclear pre-mRNA domain containing 2
Reference MIM:614695|HGNC:HGNC:29039|Ensembl:ENSG00000163125|Vega:OTTHUMG00000012808
Gene type protein-coding
Map location 1q21.3
Sherlock p-value 0.515
Fetal beta 1.16
DMG 1 (# studies)
eGene Myers' cis & trans
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07066868 1 150337482 RPRD2 5.27E-8 -0.016 1.38E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 RPRD2 23248 0.13 trans
rs16955618 chr15 29937543 RPRD2 23248 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ITPKB 0.81 0.83
LRP10 0.79 0.83
HEPACAM 0.79 0.77
NFATC1 0.78 0.77
TIMP3 0.78 0.78
ZCCHC24 0.78 0.79
CSF1 0.76 0.81
PRELP 0.76 0.80
PBXIP1 0.76 0.77
CHDH 0.75 0.78
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
POLB -0.50 -0.59
FRG1 -0.50 -0.59
STMN1 -0.49 -0.55
MED19 -0.49 -0.55
NR2C2AP -0.48 -0.55
PPP3CC -0.48 -0.51
GNL3 -0.47 -0.52
COQ3 -0.47 -0.53
C18orf21 -0.46 -0.53
C11orf57 -0.46 -0.58

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 15231747

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170 114 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 134 93 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176 115 All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE SULINDAC 6 52 32 All SZGR 2.0 genes in this pathway
由喀斯特IWANAGA致癌PTEN 181 112 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397 206 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 2 UP 54 31 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 7 UP 118 68 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227 151 All SZGR 2.0 genes in this pathway