Gene Page:ATP11A

概括?
基因 23250
Symbol ATP11A
Synonyms ATPIH|ATPIS
Description ATPase phospholipid transporting 11A
Reference MIM:605868|HGNC:HGNC:13552|Ensembl:ENSG00000068650|HPRD:12059|Vega:OTTHUMG00000017371
Gene type protein-coding
Map location 13Q34
Pascal p-value 0.056
Fetal beta -0.458
DMG 1 (# studies)

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 5
Expression Meta-analysis of gene expression Pvalue: 1.602

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg15495091 13 113491819 ATP11A 4.29E-5 0.544 0.021 DMG:Wockner_2014
cg02490942 13 113491766 ATP11A 7.11E-5 0.66 0.025 DMG:Wockner_2014
cg22253771 13 113435678 ATP11A 2.673E-4 -0.397 0.038 DMG:Wockner_2014
cg03869495 13 113492269 ATP11A 4.472E-4 0.533 0.045 DMG:Wockner_2014
cg04740513 13 113492559 ATP11A 5.728E-4 0.296 0.049 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IEA -
GO:0003824 catalytic activity IEA -
GO:0004012 phospholipid-translocating ATPase activity IEA -
GO:0005524 ATP binding IEA -
GO:0016787 hydrolase activity IEA -
GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0008152 metabolic process IEA -
GO:0006810 运输 IEA -
GO:0015914 phospholipid transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 该途径中的所有SZGR 2.0基因
REACTOME ION TRANSPORT BY P TYPE ATPASES 34 21 该途径中的所有SZGR 2.0基因
REACTOME ION CHANNEL TRANSPORT 55 42 该途径中的所有SZGR 2.0基因
ONKEN UVEAL MELANOMA DN 526 357 该途径中的所有SZGR 2.0基因
Huttmann B Cll生存不佳 276 187 该途径中的所有SZGR 2.0基因
DOANE BREAST CANCER CLASSES DN 34 26 该途径中的所有SZGR 2.0基因
VECCHI GASTRIC CANCER EARLY UP 430 232 该途径中的所有SZGR 2.0基因
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 该途径中的所有SZGR 2.0基因
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175 108 该途径中的所有SZGR 2.0基因
SENESE HDAC1 TARGETS UP 457 269 该途径中的所有SZGR 2.0基因
DELYS THYROID CANCER UP 443 294 该途径中的所有SZGR 2.0基因
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 该途径中的所有SZGR 2.0基因
PEREZ TP63 TARGETS 355 243 该途径中的所有SZGR 2.0基因
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261 153 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
GOLDRATH HOMEOSTATIC PROLIFERATION 171 102 该途径中的所有SZGR 2.0基因
切斯勒大脑最高表达 40 29 该途径中的所有SZGR 2.0基因
OKUMURA INFLAMMATORY RESPONSE LPS 183 115 该途径中的所有SZGR 2.0基因
MCCLUNG CREB1 TARGETS DN 57 39 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 48HR UP 180 125 该途径中的所有SZGR 2.0基因
MARTINEZ RB1 TARGETS DN 543 317 该途径中的所有SZGR 2.0基因
MARTINEZ TP53 TARGETS DN 593 372 该途径中的所有SZGR 2.0基因
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 该途径中的所有SZGR 2.0基因
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER BASAL UP 648 398 该途径中的所有SZGR 2.0基因
GRADE COLON CANCER UP 871 505 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA D DN 78 34 该途径中的所有SZGR 2.0基因
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 107 67 该途径中的所有SZGR 2.0基因
SWEET LUNG CANCER KRAS UP 491 316 该途径中的所有SZGR 2.0基因
LEE RECENT THYMIC EMIGRANT 227 128 该途径中的所有SZGR 2.0基因
SHEDDEN肺癌好生存A4 196 124 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA PCA3 DN 69 38 该途径中的所有SZGR 2.0基因
Dutertre雌二醇反应6小时 229 149 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS DN 1972 1213 该途径中的所有SZGR 2.0基因
CHANGOLKAR H2AFY TARGETS UP 48 28 该途径中的所有SZGR 2.0基因
PURBEY目标S OF CTBP1 NOT SATB1 UP 344 215 该途径中的所有SZGR 2.0基因
Delacroix Rarg Bound MEF 367 231 该途径中的所有SZGR 2.0基因
DELACROIX RAR TARGETS UP 48 33 该途径中的所有SZGR 2.0基因
FORTSCHEGGER PHF8 TARGETS DN 784 464 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 2239 2245 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-130/301 1887 1893 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-19 1886 1892 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
miR-224 4675 4681 1A HSA-MIR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-320 4618 4624 1A hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-410 4612 4618 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-448 4657 4663 m8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-544 4589 4596 1A,m8 hsa-miR-544 AUUCUGCAUUUUUAGCAAGU
miR-9 1584 1591 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA