Gene Page:DDHD2

Summary?
GeneID 23259
Symbol DDHD2
Synonyms SAMWD1|SPG54|iPLA(1)gamma
Description DDHD domain containing 2
Reference MIM:615003|HGNC:HGNC:29106|Ensembl:ENSG00000085788|HPRD:16788|Vega:OTTHUMG00000164095
Gene type protein-coding
Map location 8p11.23
Pascal p-value 4.753E-6
Sherlock p-value 0.619
TADA p-value 0.001
Fetal beta -0.377
eGene Caudate basal ganglia
Cerebellum
Cortex
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Xu_2012 Whole Exome Sequencing analysis 新创4基因的突变被交货确认ome sequencing of 795 samples in this study

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
DDHD2 chr8 38107312..38107317 AAACTC A NM_001164232
NM_015214		 .
.		 frameshift
frameshift		 Schizophrenia DNM:Xu_2012


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
UNC13A 0.92 0.93
PITPNM2 0.90 0.90
GARNL4 0.90 0.89
SCN3B 0.88 0.86
FRMPD4 0.88 0.91
ABR 0.88 0.89
ZC3H12B 0.88 0.86
ARHGEF3 0.88 0.86
DOCK3 0.87 0.89
RAB11FIP4 0.87 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ACAA2 -0.50 -0.53
RAB13 -0.49 -0.59
PECI -0.49 -0.54
GNG11 -0.48 -0.56
ACSF2 -0.48 -0.51
RAB34 -0.48 -0.54
C1orf54 -0.47 -0.56
AP002478.3 -0.47 -0.52
IMPA2 -0.47 -0.53
AF347015.21 -0.47 -0.46

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
IGARASHI ATF4 TARGETS DN 90 65 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 135 82 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 116 71 All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 88 60 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8P12 P11 AMPLICON 57 32 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
YAGI AML SURVIVAL 129 87 All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191 131 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163 100 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED DENDRITIC CELL 65 49 All SZGR 2.0 genes in this pathway
ASGHARZADEH NEUROBLASTOMA POOR SURVIVAL DN 46 30 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207 143 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR DN 44 34 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289 187 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206 127 All SZGR 2.0 genes in this pathway