Gene Page:MGRN1
Summary?
| GeneID | 23295 |
| Symbol | MGRN1 |
| Synonyms | RNF156 |
| Description | mahogunin ring finger 1, E3 ubiquitin protein ligase |
| Reference | MIM:607559|HGNC:HGNC:20254|Ensembl:ENSG00000102858|HPRD:07397|Vega:OTTHUMG00000176436 |
| Gene type | protein-coding |
| Map location | 16p13.3 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.87 |
| Fetal beta | 0.541 |
| DMG | 1(# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Montano_2016 | Genome-wide DNA methylation analysis | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg04962621 | 16 | 4714733 | MGRN1 | 1.32E-7 | -0.009 | 0.01 | DMG:Montano_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2834904 | chr21 | 36689995 | MGRN1 | 23295 | 0.02 | trans | ||
| rs1684619 | 16 | 4708523 | MGRN1 | ENSG00000102858.8 | 6.96E-9 | 0 | 42029 | gtex_brain_ba24 |
| rs72582364 | 16 | 4708541 | MGRN1 | ENSG00000102858.8 | 6.288E-9 | 0 | 42047 | gtex_brain_ba24 |
| rs34636732 | 16 | 4708542 | MGRN1 | ENSG00000102858.8 | 6.303E-9 | 0 | 42048 | gtex_brain_ba24 |
| rs1659500 | 16 | 4708959 | MGRN1 | ENSG00000102858.8 | 8.156E-10 | 0 | 42465 | gtex_brain_ba24 |
| rs1659501 | 16 | 4709131 | MGRN1 | ENSG00000102858.8 | 2.981E-9 | 0 | 42637 | gtex_brain_ba24 |
| rs1684620 | 16 | 4709636 | MGRN1 | ENSG00000102858.8 | 1.817E-8 | 0 | 43142 | gtex_brain_ba24 |
| rs75130634 | 16 | 4710779 | MGRN1 | ENSG00000102858.8 | 6.635E-9 | 0 | 44285 | gtex_brain_ba24 |
| rs1684623 | 16 | 4711393 | MGRN1 | ENSG00000102858.8 | 9.825E-7 | 0 | 44899 | gtex_brain_ba24 |
| rs1684624 | 16 | 4711737 | MGRN1 | ENSG00000102858.8 | 4.739E-9 | 0 | 45243 | gtex_brain_ba24 |
| rs1659503 | 16 | 4711791 | MGRN1 | ENSG00000102858.8 | 4.522E-9 | 0 | 45297 | gtex_brain_ba24 |
| rs1684625 | 16 | 4712148 | MGRN1 | ENSG00000102858.8 | 5.216E-9 | 0 | 45654 | gtex_brain_ba24 |
| rs12600113 | 16 | 4712401 | MGRN1 | ENSG00000102858.8 | 1.097E-8 | 0 | 45907 | gtex_brain_ba24 |
| rs1659480 | 16 | 4714365 | MGRN1 | ENSG00000102858.8 | 2.569E-9 | 0 | 47871 | gtex_brain_ba24 |
| rs1659479 | 16 | 4714639 | MGRN1 | ENSG00000102858.8 | 1.424E-9 | 0 | 48145 | gtex_brain_ba24 |
| rs3813746 | 16 | 4715012 | MGRN1 | ENSG00000102858.8 | 5.551E-8 | 0 | 48518 | gtex_brain_ba24 |
| rs59640193 | 16 | 4716062 | MGRN1 | ENSG00000102858.8 | 1.015E-8 | 0 | 49568 | gtex_brain_ba24 |
| rs28448402 | 16 | 4716103 | MGRN1 | ENSG00000102858.8 | 5.059E-9 | 0 | 49609 | gtex_brain_ba24 |
| rs57085123 | 16 | 4716254 | MGRN1 | ENSG00000102858.8 | 1.036E-8 | 0 | 49760 | gtex_brain_ba24 |
| rs34069734 | 16 | 4718388 | MGRN1 | ENSG00000102858.8 | 2.482E-7 | 0 | 51894 | gtex_brain_ba24 |
| rs56308101 | 16 | 4718656 | MGRN1 | ENSG00000102858.8 | 1.414E-6 | 0 | 52162 | gtex_brain_ba24 |
| rs62037139 | 16 | 4719349 | MGRN1 | ENSG00000102858.8 | 5.811E-8 | 0 | 52855 | gtex_brain_ba24 |
| rs715109 | 16 | 4721468 | MGRN1 | ENSG00000102858.8 | 4.143E-8 | 0 | 54974 | gtex_brain_ba24 |
| rs1659494 | 16 | 4722201 | MGRN1 | ENSG00000102858.8 | 2.257E-9 | 0 | 55707 | gtex_brain_ba24 |
| rs2289314 | 16 | 4723451 | MGRN1 | ENSG00000102858.8 | 4.551E-8 | 0 | 56957 | gtex_brain_ba24 |
| rs12598162 | 16 | 4724166 | MGRN1 | ENSG00000102858.8 | 8.937E-7 | 0 | 57672 | gtex_brain_ba24 |
| rs111273040 | 16 | 4724665 | MGRN1 | ENSG00000102858.8 | 4.815E-7 | 0 | 58171 | gtex_brain_ba24 |
| rs2450390 | 16 | 4725450 | MGRN1 | ENSG00000102858.8 | 3.847E-7 | 0 | 58956 | gtex_brain_ba24 |
| rs1659493 | 16 | 4725863 | MGRN1 | ENSG00000102858.8 | 5.437E-7 | 0 | 59369 | gtex_brain_ba24 |
| rs1684605 | 16 | 4726008 | MGRN1 | ENSG00000102858.8 | 6.626E-8 | 0 | 59514 | gtex_brain_ba24 |
| rs1684604 | 16 | 4726451 | MGRN1 | ENSG00000102858.8 | 4.61E-7 | 0 | 59957 | gtex_brain_ba24 |
| rs3992629 | 16 | 4728288 | MGRN1 | ENSG00000102858.8 | 2.812E-7 | 0 | 61794 | gtex_brain_ba24 |
| rs76906593 | 16 | 4728291 | MGRN1 | ENSG00000102858.8 | 8.089E-8 | 0 | 61797 | gtex_brain_ba24 |
| rs1684603 | 16 | 4728527 | MGRN1 | ENSG00000102858.8 | 4.525E-7 | 0 | 62033 | gtex_brain_ba24 |
| rs841229 | 16 | 4731155 | MGRN1 | ENSG00000102858.8 | 4.125E-7 | 0 | 64661 | gtex_brain_ba24 |
| rs841228 | 16 | 4733542 | MGRN1 | ENSG00000102858.8 | 1.235E-6 | 0 | 67048 | gtex_brain_ba24 |
| rs841227 | 16 | 4734513 | MGRN1 | ENSG00000102858.8 | 1.101E-7 | 0 | 68019 | gtex_brain_ba24 |
| rs865775 | 16 | 4735528 | MGRN1 | ENSG00000102858.8 | 2.774E-10 | 0 | 69034 | gtex_brain_ba24 |
| rs1684588 | 16 | 4735631 | MGRN1 | ENSG00000102858.8 | 2.837E-10 | 0 | 69137 | gtex_brain_ba24 |
| rs200289286 | 16 | 4736080 | MGRN1 | ENSG00000102858.8 | 2.772E-10 | 0 | 69586 | gtex_brain_ba24 |
| rs841225 | 16 | 4736316 | MGRN1 | ENSG00000102858.8 | 5.629E-11 | 0 | 69822 | gtex_brain_ba24 |
| rs841224 | 16 | 4736834 | MGRN1 | ENSG00000102858.8 | 1.538E-10 | 0 | 70340 | gtex_brain_ba24 |
| rs844488 | 16 | 4737383 | MGRN1 | ENSG00000102858.8 | 1.826E-10 | 0 | 70889 | gtex_brain_ba24 |
| rs841223 | 16 | 4737981 | MGRN1 | ENSG00000102858.8 | 6.395E-8 | 0 | 71487 | gtex_brain_ba24 |
| rs841222 | 16 | 4738251 | MGRN1 | ENSG00000102858.8 | 3.81E-8 | 0 | 71757 | gtex_brain_ba24 |
| rs1684590 | 16 | 4739514 | MGRN1 | ENSG00000102858.8 | 3.897E-7 | 0 | 73020 | gtex_brain_ba24 |
| rs3747592 | 16 | 4740208 | MGRN1 | ENSG00000102858.8 | 9.004E-8 | 0 | 73714 | gtex_brain_ba24 |
| rs1045518 | 16 | 4740441 | MGRN1 | ENSG00000102858.8 | 2.592E-8 | 0 | 73947 | gtex_brain_ba24 |
| rs1045519 | 16 | 4740444 | MGRN1 | ENSG00000102858.8 | 9.56E-8 | 0 | 73950 | gtex_brain_ba24 |
| rs1045520 | 16 | 4740477 | MGRN1 | ENSG00000102858.8 | 5.765E-8 | 0 | 73983 | gtex_brain_ba24 |
| rs841220 | 16 | 4740602 | MGRN1 | ENSG00000102858.8 | 5.562E-8 | 0 | 74108 | gtex_brain_ba24 |
| rs841219 | 16 | 4741636 | MGRN1 | ENSG00000102858.8 | 1.017E-7 | 0 | 75142 | gtex_brain_ba24 |
| rs841216 | 16 | 4746829 | MGRN1 | ENSG00000102858.8 | 9.643E-8 | 0 | 80335 | gtex_brain_ba24 |
| rs841215 | 16 | 4747136 | MGRN1 | ENSG00000102858.8 | 2.618E-7 | 0 | 80642 | gtex_brain_ba24 |
| rs74666947 | 16 | 4749860 | MGRN1 | ENSG00000102858.8 | 4.804E-7 | 0 | 83366 | gtex_brain_ba24 |
| rs841212 | 16 | 4749915 | MGRN1 | ENSG00000102858.8 | 8.605E-8 | 0 | 83421 | gtex_brain_ba24 |
| rs841211 | 16 | 4750274 | MGRN1 | ENSG00000102858.8 | 4.846 e - | 0 | 83780 | gtex_brain_ba24 |
| rs863980 | 16 | 4751045 | MGRN1 | ENSG00000102858.8 | 3.604E-7 | 0 | 84551 | gtex_brain_ba24 |
| rs841210 | 16 | 4752134 | MGRN1 | ENSG00000102858.8 | 2.547E-8 | 0 | 85640 | gtex_brain_ba24 |
| rs2404282 | 16 | 4753624 | MGRN1 | ENSG00000102858.8 | 1.343E-6 | 0 | 87130 | gtex_brain_ba24 |
| rs78958044 | 16 | 4753877 | MGRN1 | ENSG00000102858.8 | 4.197E-7 | 0 | 87383 | gtex_brain_ba24 |
| rs1684615 | 16 | 4754194 | MGRN1 | ENSG00000102858.8 | 2.07E-7 | 0 | 87700 | gtex_brain_ba24 |
| rs1684584 | 16 | 4758465 | MGRN1 | ENSG00000102858.8 | 4.193E-7 | 0 | 91971 | gtex_brain_ba24 |
| rs1684586 | 16 | 4758897 | MGRN1 | ENSG00000102858.8 | 8.278E-7 | 0 | 92403 | gtex_brain_ba24 |
| rs57183997 | 16 | 4761361 | MGRN1 | ENSG00000102858.8 | 1.417E-6 | 0 | 94867 | gtex_brain_ba24 |
| rs9921788 | 16 | 4804490 | MGRN1 | ENSG00000102858.8 | 1.167E-6 | 0 | 137996 | gtex_brain_ba24 |
| rs4785974 | 16 | 4804651 | MGRN1 | ENSG00000102858.8 | 1.646E-6 | 0 | 138157 | gtex_brain_ba24 |
| rs1684619 | 16 | 4708523 | MGRN1 | ENSG00000102858.8 | 7.271E-9 | 0 | 42029 | gtex_brain_putamen_basal |
| rs72582364 | 16 | 4708541 | MGRN1 | ENSG00000102858.8 | 9.026E-8 | 0 | 42047 | gtex_brain_putamen_basal |
| rs34636732 | 16 | 4708542 | MGRN1 | ENSG00000102858.8 | 9.149E-8 | 0 | 42048 | gtex_brain_putamen_basal |
| rs1659500 | 16 | 4708959 | MGRN1 | ENSG00000102858.8 | 4.849E-8 | 0 | 42465 | gtex_brain_putamen_basal |
| rs1659501 | 16 | 4709131 | MGRN1 | ENSG00000102858.8 | 9.235E-8 | 0 | 42637 | gtex_brain_putamen_basal |
| rs75130634 | 16 | 4710779 | MGRN1 | ENSG00000102858.8 | 4.487E-7 | 0 | 44285 | gtex_brain_putamen_basal |
| rs1684624 | 16 | 4711737 | MGRN1 | ENSG00000102858.8 | 8.051E-8 | 0 | 45243 | gtex_brain_putamen_basal |
| rs1659503 | 16 | 4711791 | MGRN1 | ENSG00000102858.8 | 1.536E-8 | 0 | 45297 | gtex_brain_putamen_basal |
| rs1684625 | 16 | 4712148 | MGRN1 | ENSG00000102858.8 | 1.224E-8 | 0 | 45654 | gtex_brain_putamen_basal |
| rs12600113 | 16 | 4712401 | MGRN1 | ENSG00000102858.8 | 6.281E-7 | 0 | 45907 | gtex_brain_putamen_basal |
| rs1659480 | 16 | 4714365 | MGRN1 | ENSG00000102858.8 | 3.86E-8 | 0 | 47871 | gtex_brain_putamen_basal |
| rs1659479 | 16 | 4714639 | MGRN1 | ENSG00000102858.8 | 2.684E-8 | 0 | 48145 | gtex_brain_putamen_basal |
| rs3813746 | 16 | 4715012 | MGRN1 | ENSG00000102858.8 | 4.68E-8 | 0 | 48518 | gtex_brain_putamen_basal |
| rs59640193 | 16 | 4716062 | MGRN1 | ENSG00000102858.8 | 3.397E-7 | 0 | 49568 | gtex_brain_putamen_basal |
| rs28448402 | 16 | 4716103 | MGRN1 | ENSG00000102858.8 | 6.237E-9 | 0 | 49609 | gtex_brain_putamen_basal |
| rs57085123 | 16 | 4716254 | MGRN1 | ENSG00000102858.8 | 3.557E-7 | 0 | 49760 | gtex_brain_putamen_basal |
| rs34069734 | 16 | 4718388 | MGRN1 | ENSG00000102858.8 | 1.118E-7 | 0 | 51894 | gtex_brain_putamen_basal |
| rs56308101 | 16 | 4718656 | MGRN1 | ENSG00000102858.8 | 3.96E-7 | 0 | 52162 | gtex_brain_putamen_basal |
| rs62037139 | 16 | 4719349 | MGRN1 | ENSG00000102858.8 | 4.635E-7 | 0 | 52855 | gtex_brain_putamen_basal |
| rs57385693 | 16 | 4719459 | MGRN1 | ENSG00000102858.8 | 3.234E-7 | 0 | 52965 | gtex_brain_putamen_basal |
| rs1659495 | 16 | 4719981 | MGRN1 | ENSG00000102858.8 | 2.213E-6 | 0 | 53487 | gtex_brain_putamen_basal |
| rs4786533 | 16 | 4720390 | MGRN1 | ENSG00000102858.8 | 2.143E-6 | 0 | 53896 | gtex_brain_putamen_basal |
| rs2278567 | 16 | 4720993 | MGRN1 | ENSG00000102858.8 | 2.734E-7 | 0 | 54499 | gtex_brain_putamen_basal |
| rs2278566 | 16 | 4721025 | MGRN1 | ENSG00000102858.8 | 2.262E-7 | 0 | 54531 | gtex_brain_putamen_basal |
| rs715109 | 16 | 4721468 | MGRN1 | ENSG00000102858.8 | 4.346E-10 | 0 | 54974 | gtex_brain_putamen_basal |
| rs1659494 | 16 | 4722201 | MGRN1 | ENSG00000102858.8 | 8.387E-9 | 0 | 55707 | gtex_brain_putamen_basal |
| rs2289314 | 16 | 4723451 | MGRN1 | ENSG00000102858.8 | 1.763E-9 | 0 | 56957 | gtex_brain_putamen_basal |
| rs12598162 | 16 | 4724166 | MGRN1 | ENSG00000102858.8 | 3.399E-8 | 0 | 57672 | gtex_brain_putamen_basal |
| rs12599757 | 16 | 4724354 | MGRN1 | ENSG00000102858.8 | 3.346E-8 | 0 | 57860 | gtex_brain_putamen_basal |
| rs111273040 | 16 | 4724665 | MGRN1 | ENSG00000102858.8 | 1.174E-6 | 0 | 58171 | gtex_brain_putamen_basal |
| rs2450390 | 16 | 4725450 | MGRN1 | ENSG00000102858.8 | 2.077E-10 | 0 | 58956 | gtex_brain_putamen_basal |
| rs1659493 | 16 | 4725863 | MGRN1 | ENSG00000102858.8 | 1.931E-9 | 0 | 59369 | gtex_brain_putamen_basal |
| rs1684605 | 16 | 4726008 | MGRN1 | ENSG00000102858.8 | 5.464E-11 | 0 | 59514 | gtex_brain_putamen_basal |
| rs1684604 | 16 | 4726451 | MGRN1 | ENSG00000102858.8 | 1.997E-9 | 0 | 59957 | gtex_brain_putamen_basal |
| rs3992629 | 16 | 4728288 | MGRN1 | ENSG00000102858.8 | 1.357E-10 | 0 | 61794 | gtex_brain_putamen_basal |
| rs76906593 | 16 | 4728291 | MGRN1 | ENSG00000102858.8 | 1.056E-9 | 0 | 61797 | gtex_brain_putamen_basal |
| rs1684603 | 16 | 4728527 | MGRN1 | ENSG00000102858.8 | 1.467E-9 | 0 | 62033 | gtex_brain_putamen_basal |
| rs841229 | 16 | 4731155 | MGRN1 | ENSG00000102858.8 | 1.144E-10 | 0 | 64661 | gtex_brain_putamen_basal |
| rs841228 | 16 | 4733542 | MGRN1 | ENSG00000102858.8 | 4.435E-9 | 0 | 67048 | gtex_brain_putamen_basal |
| rs841227 | 16 | 4734513 | MGRN1 | ENSG00000102858.8 | 8.968E-9 | 0 | 68019 | gtex_brain_putamen_basal |
| rs865775 | 16 | 4735528 | MGRN1 | ENSG00000102858.8 | 4.244E-12 | 0 | 69034 | gtex_brain_putamen_basal |
| rs1684588 | 16 | 4735631 | MGRN1 | ENSG00000102858.8 | 4.289E-12 | 0 | 69137 | gtex_brain_putamen_basal |
| rs200289286 | 16 | 4736080 | MGRN1 | ENSG00000102858.8 | 7.482E-13 | 0 | 69586 | gtex_brain_putamen_basal |
| rs841225 | 16 | 4736316 | MGRN1 | ENSG00000102858.8 | 1.957E-13 | 0 | 69822 | gtex_brain_putamen_basal |
| rs841224 | 16 | 4736834 | MGRN1 | ENSG00000102858.8 | 8.473E-12 | 0 | 70340 | gtex_brain_putamen_basal |
| rs844488 | 16 | 4737383 | MGRN1 | ENSG00000102858.8 | 1.135 e-12 | 0 | 70889 | gtex_brain_putamen_basal |
| rs841223 | 16 | 4737981 | MGRN1 | ENSG00000102858.8 | 5.956E-8 | 0 | 71487 | gtex_brain_putamen_basal |
| rs841222 | 16 | 4738251 | MGRN1 | ENSG00000102858.8 | 1.211E-7 | 0 | 71757 | gtex_brain_putamen_basal |
| rs1684590 | 16 | 4739514 | MGRN1 | ENSG00000102858.8 | 4.194E-9 | 0 | 73020 | gtex_brain_putamen_basal |
| rs3747592 | 16 | 4740208 | MGRN1 | ENSG00000102858.8 | 1.208E-11 | 0 | 73714 | gtex_brain_putamen_basal |
| rs1045518 | 16 | 4740441 | MGRN1 | ENSG00000102858.8 | 4.334E-10 | 0 | 73947 | gtex_brain_putamen_basal |
| rs1045519 | 16 | 4740444 | MGRN1 | ENSG00000102858.8 | 9.646E-11 | 0 | 73950 | gtex_brain_putamen_basal |
| rs1045520 | 16 | 4740477 | MGRN1 | ENSG00000102858.8 | 1.389E-9 | 0 | 73983 | gtex_brain_putamen_basal |
| rs841220 | 16 | 4740602 | MGRN1 | ENSG00000102858.8 | 2.374E-9 | 0 | 74108 | gtex_brain_putamen_basal |
| rs841219 | 16 | 4741636 | MGRN1 | ENSG00000102858.8 | 2.029E-11 | 0 | 75142 | gtex_brain_putamen_basal |
| rs841218 | 16 | 4742979 | MGRN1 | ENSG00000102858.8 | 6.801E-9 | 0 | 76485 | gtex_brain_putamen_basal |
| rs841217 | 16 | 4746392 | MGRN1 | ENSG00000102858.8 | 1.177E-7 | 0 | 79898 | gtex_brain_putamen_basal |
| rs841216 | 16 | 4746829 | MGRN1 | ENSG00000102858.8 | 4.746E-9 | 0 | 80335 | gtex_brain_putamen_basal |
| rs841215 | 16 | 4747136 | MGRN1 | ENSG00000102858.8 | 1.058E-7 | 0 | 80642 | gtex_brain_putamen_basal |
| rs841214 | 16 | 4748825 | MGRN1 | ENSG00000102858.8 | 9.194E-8 | 0 | 82331 | gtex_brain_putamen_basal |
| rs74666947 | 16 | 4749860 | MGRN1 | ENSG00000102858.8 | 1.666E-8 | 0 | 83366 | gtex_brain_putamen_basal |
| rs841212 | 16 | 4749915 | MGRN1 | ENSG00000102858.8 | 5.134E-9 | 0 | 83421 | gtex_brain_putamen_basal |
| rs841211 | 16 | 4750274 | MGRN1 | ENSG00000102858.8 | 1.662E-8 | 0 | 83780 | gtex_brain_putamen_basal |
| rs863980 | 16 | 4751045 | MGRN1 | ENSG00000102858.8 | 1.536E-8 | 0 | 84551 | gtex_brain_putamen_basal |
| rs841210 | 16 | 4752134 | MGRN1 | ENSG00000102858.8 | 1.062E-9 | 0 | 85640 | gtex_brain_putamen_basal |
| rs2404282 | 16 | 4753624 | MGRN1 | ENSG00000102858.8 | 2.825E-8 | 0 | 87130 | gtex_brain_putamen_basal |
| rs78958044 | 16 | 4753877 | MGRN1 | ENSG00000102858.8 | 2.429E-9 | 0 | 87383 | gtex_brain_putamen_basal |
| rs1684615 | 16 | 4754194 | MGRN1 | ENSG00000102858.8 | 6.176E-10 | 0 | 87700 | gtex_brain_putamen_basal |
| rs1684616 | 16 | 4755639 | MGRN1 | ENSG00000102858.8 | 5.121E-7 | 0 | 89145 | gtex_brain_putamen_basal |
| rs1684617 | 16 | 4756544 | MGRN1 | ENSG00000102858.8 | 1.177E-6 | 0 | 90050 | gtex_brain_putamen_basal |
| rs1659492 | 16 | 4757416 | MGRN1 | ENSG00000102858.8 | 1.714E-7 | 0 | 90922 | gtex_brain_putamen_basal |
| rs1659491 | 16 | 4757475 | MGRN1 | ENSG00000102858.8 | 1.717E-7 | 0 | 90981 | gtex_brain_putamen_basal |
| rs1684584 | 16 | 4758465 | MGRN1 | ENSG00000102858.8 | 7.614E-7 | 0 | 91971 | gtex_brain_putamen_basal |
| rs1684586 | 16 | 4758897 | MGRN1 | ENSG00000102858.8 | 1.768E-7 | 0 | 92403 | gtex_brain_putamen_basal |
| rs1684587 | 16 | 4759865 | MGRN1 | ENSG00000102858.8 | 1.794E-7 | 0 | 93371 | gtex_brain_putamen_basal |
| rs28843142 | 16 | 4761036 | MGRN1 | ENSG00000102858.8 | 8.97E-7 | 0 | 94542 | gtex_brain_putamen_basal |
| rs57183997 | 16 | 4761361 | MGRN1 | ENSG00000102858.8 | 1.421E-7 | 0 | 94867 | gtex_brain_putamen_basal |
| rs859325 | 16 | 4765948 | MGRN1 | ENSG00000102858.8 | 9.719E-7 | 0 | 99454 | gtex_brain_putamen_basal |
| rs859326 | 16 | 4766155 | MGRN1 | ENSG00000102858.8 | 2.294E-7 | 0 | 99661 | gtex_brain_putamen_basal |
| rs859328 | 16 | 4766326 | MGRN1 | ENSG00000102858.8 | 1.492E-7 | 0 | 99832 | gtex_brain_putamen_basal |
| rs859295 | 16 | 4771918 | MGRN1 | ENSG00000102858.8 | 3.212E-7 | 0 | 105424 | gtex_brain_putamen_basal |
| rs703813 | 16 | 4780696 | MGRN1 | ENSG00000102858.8 | 1.186E-6 | 0 | 114202 | gtex_brain_putamen_basal |
| rs859323 | 16 | 4781692 | MGRN1 | ENSG00000102858.8 | 1.715E-6 | 0 | 115198 | gtex_brain_putamen_basal |
| rs859317 | 16 | 4782875 | MGRN1 | ENSG00000102858.8 | 1.675E-6 | 0 | 116381 | gtex_brain_putamen_basal |
| rs859315 | 16 | 4785807 | MGRN1 | ENSG00000102858.8 | 1.845E-6 | 0 | 119313 | gtex_brain_putamen_basal |
| rs4038772 | 16 | 4786305 | MGRN1 | ENSG00000102858.8 | 1.905E-6 | 0 | 119811 | gtex_brain_putamen_basal |
| rs2579667 | 16 | 4788821 | MGRN1 | ENSG00000102858.8 | 2.129E-6 | 0 | 122327 | gtex_brain_putamen_basal |
| rs2605572 | 16 | 4788823 | MGRN1 | ENSG00000102858.8 | 2.129E-6 | 0 | 122329 | gtex_brain_putamen_basal |
| rs2605573 | 16 | 4789213 | MGRN1 | ENSG00000102858.8 | 2.144E-6 | 0 | 122719 | gtex_brain_putamen_basal |
| rs397739237 | 16 | 4793511 | MGRN1 | ENSG00000102858.8 | 4.438E-7 | 0 | 127017 | gtex_brain_putamen_basal |
| rs2305657 | 16 | 4793658 | MGRN1 | ENSG00000102858.8 | 3.38E-7 | 0 | 127164 | gtex_brain_putamen_basal |
| rs1563444 | 16 | 4794227 | MGRN1 | ENSG00000102858.8 | 3.613E-7 | 0 | 127733 | gtex_brain_putamen_basal |
| rs2075469 | 16 | 4794873 | MGRN1 | ENSG00000102858.8 | 1.52E-7 | 0 | 128379 | gtex_brain_putamen_basal |
| rs2075470 | 16 | 4795245 | MGRN1 | ENSG00000102858.8 | 2.123E-6 | 0 | 128751 | gtex_brain_putamen_basal |
| rs2075471 | 16 | 4795273 | MGRN1 | ENSG00000102858.8 | 3.596E-7 | 0 | 128779 | gtex_brain_putamen_basal |
| rs741694 | 16 | 4795554 | MGRN1 | ENSG00000102858.8 | 1.415E-6 | 0 | 129060 | gtex_brain_putamen_basal |
| rs2341989 | 16 | 4795892 | MGRN1 | ENSG00000102858.8 | 3.596E-7 | 0 | 129398 | gtex_brain_putamen_basal |
| rs3888386 | 16 | 4795908 | MGRN1 | ENSG00000102858.8 | 6.375E-8 | 0 | 129414 | gtex_brain_putamen_basal |
| rs737698 | 16 | 4796084 | MGRN1 | ENSG00000102858.8 | 3.872E-7 | 0 | 129590 | gtex_brain_putamen_basal |
| rs737697 | 16 | 4796192 | MGRN1 | ENSG00000102858.8 | 7.882E-8 | 0 | 129698 | gtex_brain_putamen_basal |
| rs737700 | 16 | 4796393 | MGRN1 | ENSG00000102858.8 | 7.882E-8 | 0 | 129899 | gtex_brain_putamen_basal |
| rs759988 | 16 | 4796595 | MGRN1 | ENSG00000102858.8 | 3.872E-7 | 0 | 130101 | gtex_brain_putamen_basal |
| rs759989 | 16 | 4797226 | MGRN1 | ENSG00000102858.8 | 1.625E-7 | 0 | 130732 | gtex_brain_putamen_basal |
| rs17853375 | 16 | 4797457 | MGRN1 | ENSG00000102858.8 | 1.181E-6 | 0 | 130963 | gtex_brain_putamen_basal |
| rs59575807 | 16 | 4797794 | MGRN1 | ENSG00000102858.8 | 1.472E-7 | 0 | 131300 | gtex_brain_putamen_basal |
| rs2341987 | 16 | 4798201 | MGRN1 | ENSG00000102858.8 | 2.123E-6 | 0 | 131707 | gtex_brain_putamen_basal |
| rs2290560 | 16 | 4799041 | MGRN1 | ENSG00000102858.8 | 1.625E-7 | 0 | 132547 | gtex_brain_putamen_basal |
| rs12162062 | 16 | 4800009 | MGRN1 | ENSG00000102858.8 | 3.872E-7 | 0 | 133515 | gtex_brain_putamen_basal |
| rs11076845 | 16 | 4801366 | MGRN1 | ENSG00000102858.8 | 7.519E-7 | 0 | 134872 | gtex_brain_putamen_basal |
| rs921863 | 16 | 4801723 | MGRN1 | ENSG00000102858.8 | 3.02E-7 | 0 | 135229 | gtex_brain_putamen_basal |
| rs921864 | 16 | 4801842 | MGRN1 | ENSG00000102858.8 | 2.224E-6 | 0 | 135348 | gtex_brain_putamen_basal |
| rs3747601 | 16 | 4802370 | MGRN1 | ENSG00000102858.8 | 3.887E-7 | 0 | 135876 | gtex_brain_putamen_basal |
| rs3747602 | 16 | 4802386 | MGRN1 | ENSG00000102858.8 | 5.813E-7 | 0 | 135892 | gtex_brain_putamen_basal |
| rs963712 | 16 | 4803327 | MGRN1 | ENSG00000102858.8 | 1.729E-6 | 0 | 136833 | gtex_brain_putamen_basal |
| rs9921788 | 16 | 4804490 | MGRN1 | ENSG00000102858.8 | 4.634E-7 | 0 | 137996 | gtex_brain_putamen_basal |
| rs4785974 | 16 | 4804651 | MGRN1 | ENSG00000102858.8 | 2.086E-7 | 0 | 138157 | gtex_brain_putamen_basal |
| rs9937064 | 16 | 4806185 | MGRN1 | ENSG00000102858.8 | 4.2E-7 | 0 | 139691 | gtex_brain_putamen_basal |
| rs72770396 | 16 | 4806388 | MGRN1 | ENSG00000102858.8 | 1.171E-6 | 0 | 139894 | gtex_brain_putamen_basal |
| rs2085330 | 16 | 4807064 | MGRN1 | ENSG00000102858.8 | 9.322E-7 | 0 | 140570 | gtex_brain_putamen_basal |
| rs2061212 | 16 | 4807403 | MGRN1 | ENSG00000102858.8 | 8.581E-7 | 0 | 140909 | gtex_brain_putamen_basal |
| rs9921524 | 16 | 4807751 | MGRN1 | ENSG00000102858.8 | 7.05E-7 | 0 | 141257 | gtex_brain_putamen_basal |
| rs9935103 | 16 | 4808260 | MGRN1 | ENSG00000102858.8 | 7.163E-7 | 0 | 141766 | gtex_brain_putamen_basal |
| rs3747603 | 16 | 4808523 | MGRN1 | ENSG00000102858.8 | 7.868E-7 | 0 | 142029 | gtex_brain_putamen_basal |
| rs34448916 | 16 | 4808911 | MGRN1 | ENSG00000102858.8 | 1.456E-6 | 0 | 142417 | gtex_brain_putamen_basal |
| rs9673738 | 16 | 4809008 | MGRN1 | ENSG00000102858.8 | 7.32E-7 | 0 | 142514 | gtex_brain_putamen_basal |
| rs62036067 | 16 | 4809734 | MGRN1 | ENSG00000102858.8 | 1.181E-6 | 0 | 143240 | gtex_brain_putamen_basal |
| rs66507473 | 16 | 4809804 | MGRN1 | ENSG00000102858.8 | 1.181E-6 | 0 | 143310 | gtex_brain_putamen_basal |
| rs9936227 | 16 | 4811179 | MGRN1 | ENSG00000102858.8 | 6.224E-8 | 0 | 144685 | gtex_brain_putamen_basal |
| rs12599765 | 16 | 4812209 | MGRN1 | ENSG00000102858.8 | 2.086E-7 | 0 | 145715 | gtex_brain_putamen_basal |
| rs4786546 | 16 | 4814767 | MGRN1 | ENSG00000102858.8 | 1.452E-6 | 0 | 148273 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf32 | 0.83 | 0.85 |
| TNFSF12 | 0.83 | 0.82 |
| BDH1 | 0.83 | 0.83 |
| GNPTG | 0.82 | 0.86 |
| CA11 | 0.81 | 0.85 |
| SHISA4 | 0.80 | 0.82 |
| DHX58 | 0.80 | 0.80 |
| GCAT | 0.80 | 0.79 |
| ANGPTL6 | 0.79 | 0.82 |
| SULT1A1 | 0.79 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KIAA1949 | -0.70 | -0.59 |
| ZNF551 | -0.67 | -0.61 |
| TUBB2B | -0.67 | -0.59 |
| THOC2 | -0.67 | -0.71 |
| AC004017.1 | -0.67 | -0.61 |
| ZNF311 | -0.67 | -0.59 |
| ZNF193 | -0.66 | -0.61 |
| FNBP1L | -0.66 | -0.60 |
| ZNF300 | -0.66 | -0.58 |
| SETDB1 | -0.66 | -0.57 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG UBIQUITIN MEDIATED PROTEOLYSIS | 138 | 98 | All SZGR 2.0 genes in this pathway |
| WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP | 108 | 67 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL UP | 380 | 215 | All SZGR 2.0 genes in this pathway |
| TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER UP | 443 | 294 | All SZGR 2.0 genes in this pathway |
| DASU IL6 SIGNALING SCAR UP | 30 | 21 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| AMBROSINI FLAVOPIRIDOL TREATMENT TP53 | 109 | 63 | All SZGR 2.0 genes in this pathway |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | 354 | 216 | All SZGR 2.0 genes in this pathway |
| DASU IL6 SIGNALING UP | 59 | 44 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 1HR DN | 222 | 147 | All SZGR 2.0 genes in this pathway |
| 金所有障碍少突细胞数量。柯尔 | 756 | 494 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |