Gene Page:DMXL2

Summary?
GeneID 23312
Symbol DMXL2
Synonyms PEPNS|RC3
Description Dmx like 2
Reference MIM:612186|HGNC:HGNC:2938|Ensembl:ENSG00000104093|HPRD:10188|Vega:OTTHUMG00000131749
Gene type protein-coding
Map location 15q21.2
Pascal p-value 0.027
eGene Cerebellar Hemisphere
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
CompositeSet
Darnell FMRP targets

基因数据urces
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AARS 0.91 0.87
C16orf5 0.90 0.89
GPI 0.88 0.88
SYN1 0.87 0.90
CAMKK1 0.87 0.88
PPP1R3F 0.87 0.88
TMEM130 0.87 0.88
PELI3 0.87 0.89
CTSD 0.86 0.85
LIMK1 0.86 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM159B -0.49 -0.62
RP9P -0.46 -0.46
IL32 -0.46 -0.33
GNG11 -0.44 -0.31
AC135724.1 -0.43 -0.44
SPINK8 -0.43 -0.43
AL050337.1 -0.43 -0.33
AF347015.21 -0.42 -0.17
AC087071.1 -0.42 -0.31
NSBP1 -0.42 -0.39

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003743 translation initiation factor activity IEA -
GO:0017137 Rab GTPase binding IDA 11809763
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006413 translational initiation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0008021 synaptic vesicle IDA Synap, Neurotransmitter (GO term level: 12) 11809763
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0016020 membrane IEA -
GO:0030054 cell junction IEA -
GO:0031410 cytoplasmic vesicle IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 所有SZGR 2.0基因通路
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 所有SZGR 2.0基因通路
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177 110 所有SZGR 2.0基因通路
GAL LEUKEMIC STEM CELL DN 244 153 所有SZGR 2.0基因通路
BASAKI YBX1 TARGETS DN 384 230 所有SZGR 2.0基因通路
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 85 54 所有SZGR 2.0基因通路
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182 110 所有SZGR 2.0基因通路
NAGASHIMA NRG1 SIGNALING DN 58 35 所有SZGR 2.0基因通路
SCHLOSSER SERUM RESPONSE DN 712 443 所有SZGR 2.0基因通路
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 所有SZGR 2.0基因通路
BENPORATH CYCLING GENES 648 385 所有SZGR 2.0基因通路
ZHAN MULTIPLE MYELOMA CD1 AND CD2 DN 51 32 所有SZGR 2.0基因通路
HASLINGER B CLL WITH 11Q23 DELETION 23 18 所有SZGR 2.0基因通路
VERHAAK AML WITH NPM1 MUTATED UP 183 111 所有SZGR 2.0基因通路
YAGI AML SURVIVAL 129 87 所有SZGR 2.0基因通路
BLALOCK ALZHEIMERS DISEASE DN 1237 837 所有SZGR 2.0基因通路
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 所有SZGR 2.0基因通路
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 所有SZGR 2.0基因通路
RUTELLA RESPONSE TO HGF UP 418 282 所有SZGR 2.0基因通路
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 所有SZGR 2.0基因通路
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 所有SZGR 2.0基因通路
VALK AML WITH EVI1 25 15 所有SZGR 2.0基因通路
YAGI AML WITH 11Q23 REARRANGED 351 238 所有SZGR 2.0基因通路
WHITFIELD CELL CYCLE S 162 86 所有SZGR 2.0基因通路
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397 206 所有SZGR 2.0基因通路
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 所有SZGR 2.0基因通路
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 所有SZGR 2.0基因通路

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-138 1043 1049 1A hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-153 917 923 m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-181 838 844 m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-19 618 625 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-193 857 863 m8 hsa-miR-193a AACUGGCCUACAAAGUCCCAG
hsa-miR-193b AACUGGCCCUCAAAGUCCCGCUUU
miR-205 218 225 1A,m8 hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-214 526 533 1A,m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-27 1149 1155 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-30-5p 1038 1044 m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-33 597 603 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-363 586 592 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
miR-381 908 914 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-496 1162 1168 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-543 1072 1078 m8 hsa-miR-543 AAACAUUCGCGGUGCACUUCU
hsa-miR-543 AAACAUUCGCGGUGCACUUCU