Gene Page:FMR1

Summary?
GeneID 2332
Symbol FMR1
Synonyms FMRP|FRAXA|POF|POF1
Description 脆性X智力迟钝1
Reference MIM:309550|HGNC:HGNC:3775|Ensembl:ENSG00000102081|HPRD:02398|Vega:OTTHUMG00000022606
Gene type protein-coding
Map location Xq27.3
Sherlock p-value 0.675
Fetal beta -0.109
Support Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias,schizotypal Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CP 0.91 0.50
KCNJ13 0.90 0.41
CLIC6 0.90 0.45
TTR 0.89 0.54
F5 0.88 0.33
SLC13A4 0.88 0.27
PRLR 0.85 0.20
SLC5A5 0.85 0.24
ABCA4 0.84 0.30
TRPV4 0.82 0.31
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EPHB6 -0.17 -0.36
IER5L -0.16 -0.53
CIDEA -0.15 -0.49
RND1 -0.15 -0.37
ARL4D -0.15 -0.48
LNX1 -0.14 -0.41
CACNB3 -0.14 -0.38
MEF2C -0.14 -0.59
LDB2 -0.14 -0.46
EFNA5 -0.14 -0.51

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003723 RNA binding IEA -
GO:0003729 mRNA binding TAS 7692601
GO:0005515 protein binding 新闻学会 10556305|16407062
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007417 central nervous system development IEA Brain (GO term level: 6) -
GO:0006810 transport IEA -
GO:0051028 mRNA transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005625 soluble fraction TAS 8401578
GO:0005634 nucleus IEA -
GO:0005654 nucleoplasm TAS 10888599
GO:0005730 nucleolus TAS 16407062
GO:0005737 cytoplasm TAS 16407062
GO:0042788 polysomal ribosome TAS 12837692

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CYFIP1 FLJ45151 | P140SRA-1 | SHYC | SRA1 cytoplasmic FMR1 interacting protein 1 - HPRD,BioGRID 11438699
CYFIP2 PIR121 cytoplasmic FMR1 interacting protein 2 - HPRD,BioGRID 11438699
FMR1 FMRP | FRAXA | MGC87458 | POF | POF1 脆性X智力迟钝1 Affinity Capture-Western BioGRID 10567518
FXR1 - fragile X mental retardation, autosomal homolog 1 - HPRD,BioGRID 7489725|8668200
FXR2 FMR1L2 fragile X mental retardation, autosomal homolog 2 - HPRD,BioGRID 7489725|8668200
|10567518
MAP1B DKFZp686E1099 | DKFZp686F1345 | FLJ38954 | FUTSCH | MAP5 microtubule-associated protein 1B FMR1 (FMRP) interacts with MAP1B mRNA. This interaction was modeled on a demonstrated interaction between FMR1 from an unspecified species and human MAP1B mRNA. BIND 15381419
NCL C23 | FLJ45706 nucleolin Affinity Capture-Western BioGRID 10567518
NUFIP1 NUFIP | bA540M5.1 nuclear fragile X mental retardation protein interacting protein 1 - HPRD,BioGRID 10556305
NUFIP2 182-FIP | 82-FIP | FIP-82 | FLJ10976 | KIAA1321 | MGC117262 | PIG1 nuclear fragile X mental retardation protein interacting protein 2 - HPRD,BioGRID 12837692
RANBP9 RANBPM RAN binding protein 9 FMR1 (FMRP) interacts with RANBP9 (RanBPM). BIND 15381419
UBE2I C358B7.1 | P18 | UBC9 ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) - HPRD,BioGRID 11367701


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP 59 38 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED DN 86 47 All SZGR 2.0 genes in this pathway
SLEBOS HEAD AND NECK CANCER WITH HPV UP 84 43 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293 193 All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203 135 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL 254 164 All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217 138 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 97 53 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185 116 All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL UP 193 95 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 1620 1626 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-124/506 544 550 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-125/351 595 601 1A hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
miR-129-5p 523 530 1A,m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-130/301 2009 2015 1A hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-132/212 1885 1891 1A hsa-miR-212深圳 UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG
miR-136 2113 2119 m8 hsa-miR-136 ACUCCAUUUGUUUUGAUGAUGGA
miR-139 1621 1628 1A,m8 hsa-miR-139brain UCUACAGUGCACGUGUCU
miR-141/200a 776 782 1A hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-144 1619 1626 1A,m8 hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-148/152 756 763 1A,m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-153 1753 1759 1A hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-181 1550 1556 1A hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181b深圳 AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 1510 1517 1A,m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-19 1584 1590 1A hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-194 1886 1892 m8 hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
miR-200bc/429 468 474 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-203.1 426 432 1A hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-205 1276 1282 1A hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-221/222 631 638 1A,m8 hsa-miR-221brain AGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC
miR-23 1273 1279 1A hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-24* 88 95 1A,m8 hsa-miR-189 GUGCCUACUGAGCUGAUAUCAGU
miR-25/32/92/363/367 1738 1745 1A,m8 hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92b深圳 UAUUGCACUCGUCCCGGCCUC
miR-323 2064 2070 1A hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-324-3p 273 279 1A hsa-miR-324-3p CCACUGCCCCAGGUGCUGCUGG
miR-324-5p 584 590 1A hsa-miR-324-5p CGCAUCCCCUAGGGCAUUGGUGU
miR-335 1665 1671 m8 hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-369-3p 574 580 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 574 580 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-377 493 499 m8 hsa-miR-377 AUCACACAAAGGCAACUUUUGU
miR-410 1298 1304 m8 hsa-miR-410 AAUAUAACACAGAUGGCCUGU
hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-448 1753 1759 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-450 523 529 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
miR-485-3p 534 540 m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-490 1090 1096 1A hsa-miR-490 民航总局CUGGAGGACUCCAUGCUG
miR-496 2237 2243 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-543 621 627 1A hsa-miR-543 AAACAUUCGCGGUGCACUUCU
miR-9 75 81 1A hsa-miR-9深圳 UCUUUGGUUAUCUAGCUGUAUGA
miR-96 1511 1517 1A hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC